Hand vein responses to noradrenaline in normotensive patients with insulin-dependent diabetes mellitus and microalbuminuria: Effects of α-adrenoceptor blockade with doxazosin

Current Medical Research and Opinion

Volumn 15, Issue 3, 1999, Pages 169-176

  Bodmer, C W ^a   Lake, D ^a   Savage, M W ^a   Williams, G ^a  

^a East Suffolk and North Essex Foundation Trust   (United Kingdom)

Author keywords

Doxazosin; Hand vein response; Microalbuminuria; adrenoceptors

Indexed keywords

DOXAZOSIN; NORADRENALIN;

ADULT; ARTICLE; BLOOD VESSEL REACTIVITY; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIABETIC NEPHROPATHY; FEMALE; HAND; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; MALE; MICROALBUMINURIA; ORAL DRUG ADMINISTRATION; PILOT STUDY; SIDE EFFECT; URINARY EXCRETION; VASOCONSTRICTION;

EID: 0032820399     PISSN: 03007995     EISSN: None     Source Type: Journal    
DOI: 10.1185/03007999909114088     Document Type: Article

References (28)

1. Andersen, A. R., Christiansen, J. S., Andersen, J. K., Kreiner, S. and Deckert, T. (1983). Diabetic nephropathy in type I (insulin-dependent) diabetes: an epidemiological study. Diabetologia, 25, 496-501.
2. Mogensen, C. E., Christensen, C. K. and Vittinghus, E. (1983). The stages in diabetic renal disease, with emphasis on the stage of incipient diabetic nephropathy. Diabetes, 32 (Suppl 2), 64-78.
3. Winocour, P. H. (1992). Microalbuminuria: worth screening for in early morning urine samples in diabetic, hypertensive and elderly patients. BMJ, 304, 1196-1197.
4. Brancati, F. L. and Cusumano, A. M. (1995). Epidemiology and prevention of diabetic nephropathy. Curr. Opin. Nephrol. Hyperten., 4, 223-229.
5. Mogensen, C. E., Keane, W. F., Bennett, P. H., Jerums, G., Parving, H. H., Passa, P., et al. (1995). Prevention of diabetic renal disease with specific reference to microalbuminuria. Lancet, 346, 1080-1084.
6. Barnett, A. H., Dallinger, K., Jennings, P., Fletcher, J. and Odughesan, O. (1985). Microalbuminuria and diabetic retinopathy. Lancet, 1, 53-54.
7. Yudkin, J. S., Forrest, R. and Jackson, C. A. (1988). Microalbuminuria as predictor of vascular disease in non-diabetic subjects. Lancet, 2, 530-533.
8. Bodmer, C. W., Patrick, A. W., How, T. V. and Williams, G. (1992). Exaggerated sensitivity to NE-induced vasoconstriction in IDDM patients with microalbuminuria. Diabetes, 41, 209-214.
9. Aellig, W. H. (1981). A new technique for recording compliance of human hand veins. Br. J. Clin. Pharmacol., 11, 237-243.
10. Bulbring, E. and Tomita, T. (1987). Catecholamine action on smooth muscle. Pharmacol. Rev., 39, 49-95.
11. Vanhoutte, P. M. and Shepherd, J. T. (1985). Adrenergic pharmacology of human and canine peripheral veins. Fed. Proc., 44, 337-340.
12. Alradi, A. O. and Carruthers, S. G. (1985). Evaluation and application of the linear variable differential transformer technique for the assessment of human dorsal hand vein alpha-receptor activity. Clin. Pharmacol. Ther., 38, 495-502.
13. Parving, H. H., Andersen, A. R., Hommel, E. and Smidt, U. (1985). Effects of long-term antihypertensive treatment on kidney function in diabetic nephropathy. Hypertension, 7, 114S-117S.
14. Zatz, R., Dunn, B. R., Meyer, T. W., Anderson, S., Rennke, H. G. and Brenner, B. M. (1986). Prevention of diabetic glomerulopathy by pharmacological amelioration of glomerular capillary hypertension. J. Clin. Invest., 77, 1925-1930.
15. Dominguez, L. J., Barbagallo, M., Kattah, W., Garcia, D. and Savers, J. R. (1995). Quinapril reduces microalbuminuria in essential hypertensive and in diabetic hypertensive subjects. Am. J. Hypertens., 8, 808-814.
16. Laffel, L. M., McGill, J. B. and Gans, D. J. (1995). The beneficial effect of angiotensin-converting enzyme inhibition with captopril on diabetic nephropathy in normotensive IDDM patients with microalbuminuria. Am. J. Med., 99, 497-504.
17. Melbourne Diabetic Nephropathy Study Group (1991). Comparison between perindopril and nifedipine in hypertensive and normotensive diabetic patients with microalbuminuria. BMJ, 302, 210-216.
18. Parving, H. H. and Rossing, P. (1994). The use of antihypertensive agents in prevention and treatment of diabetic nephropathy. Curr. Opin. Nephrol. Hyperten., 3, 292-300.
19. Feher, M. D. (1991). Doxazosin therapy in the treatment of diabetic hypertension. Am. Heart J., 121, 1291-1301.
20. Fulton, B., Wagstaff, A. J. and Sorkin, E. M. (1995). Doxazosin: an update of its clinical pharmacology and therapeutic applications in hypertension and benign prostatic hyperplasia. Drugs, 49, 295-320.
21. Winocour, P. H., Catalano, C., New, J. and Alberti, K. G. M. M. (1995). Contrasting renal and metabolic effects of alpha-and beta-adrenergic blockade in mildly hypertensive type 1 (insulin-dependent) diabetic subjects. Nutr. Metab. Cardiovasc. Dis., 5, 217-224.
22. Houben, A. J. H. M., Schaper, N. C., de Haan, C. H. A., Huvers, F. C., Slaaf, D. W., de Leeuw, P. W., et al (1994). The effects of 7-hour local hyperglycaemia on forearm macro-and micro-circulatory blood flow and vascular reactivity in healthy man. Diabetologia, 37, 750-756.
23. Jyothirmayi, G. N., Alluru, I. and Reddi, A. S. (1996). Doxazosin prevents proteinuria and glomerular loss of heparan sulfate in diabetic rats. Hypertension, 27, 1108-1114.
24. Mathiesen, E. R., Hommel, E., Giese, J. and Parving, H. H. (1991). Efficacy of captopril in postponing nephropathy in normotensive insulin dependent diabetic patients with microalbuminuria. BMJ, 303, 81-87.
25. Viberti, G., Mogensen, C. E., Groop, L. C. and Pauls, J. F. (1994). Effect of captopril on progression to clinical proteinuria in patients with insulin-dependent diabetes mellitus and microalbuminuria. JAMA, 271, 275-279.
26. Anderson, P. W. and Hsueh, W. A. (1994). Hypertension and diabetic vascular complications. Adv. Intern. Med., 39, 633-665.
27. Dunsmuir, W. D. and Holmes, S. A. (1996). The aetiology and management of erectile, ejaculatory, and fertility problems in men with diabetes mellitus. Diabet. Med., 13, 700-708.
28. Grimm, R. H., Grandits, G. A., Prineas, R. J., McDonald, R. H., Lewis, C. E., Flack, J. M., et al. (1997). Long-term effects on sexual function of five antihypertensive drugs and nutritional hygienic treatment in hypertensive men and women. Treatment of Mild Hypertension Study (TOMHS). Hypertension, 29, 8-14.