Polyamine synthesis and transport inhibition in a human anaplastic thyroid carcinoma cell line in vitro and as xenograft tumors

Thyroid

Volumn 9, Issue 8, 1999, Pages 805-814

  Yatin, Mustafa ^a   Venkataraman, Gopalakrishnan M ^a   Marcinek, Regina ^a   Ain, Kenneth B ^a  

^a UNIVERSITY OF KENTUCKY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACYLTRANSFERASE; ADENOSYLMETHIONINE DECARBOXYLASE; ANTINEOPLASTIC AGENT; EFLORNITHINE; N1 ACETYLSPERMIDINE; ORNITHINE DECARBOXYLASE; POLYAMINE; PUTRESCINE; SPERMIDINE; SPERMINE;

AMINE TRANSPORT; ANAPLASTIC CARCINOMA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CONTROLLED STUDY; CYTOTOXICITY; DRUG TARGETING; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; NONHUMAN; NUDE MOUSE; POLYAMINE METABOLISM; POLYAMINE SYNTHESIS; PRIORITY JOURNAL; THYROID CARCINOMA; TUMOR XENOGRAFT;

EID: 0032820024     PISSN: 10507256     EISSN: None     Source Type: Journal    
DOI: 10.1089/thy.1999.9.805     Document Type: Article

References (68)

1. Pegg AE, McCann PP 1982 Polyamine metabolism and function. Cell Physiol 12:c212-c221.
2. Pegg AE 1986 Review Article: Recent advances in the biochemistry of polyamines in eukaryotes. Biochem J 234:249-262.
3. Seiler N, Delcros JG, Moulinoux JP 1996 Polyamine transport in mammalian cells. An update. Int J Biochem Cell Biol 28:843-861.
4. Sarhan S, Knogden B, Seiler N 1992 Polyamine deprivation, malnutrition and tumor growth. Anticancer Res 12:457-466.
5. Jänne J, Pösö H, Raina A 1978 Polyamines in rapid growth and cancer. Biochim Biophys Acta 473:241-293.
6. Matsuzaki S, Suzuki M, Hamana K, Itoh K 1978 Elevated levels of polyamines and histamine in adenocarcinomas of the thyroid. J Clin Endocrinol Metab 47:1038-1041.
7. Yamamoto O 1989 Ornithine decarboxylase activity and polyamine levels in human thyroid tissue. Nippon Geka Gakkai Zasshi 90:1049-1056.
8. Sjöholm Å, Bucht E, Theodorsson E, Larsson R, Nygren P 1994 Polyamines regulate human medullary thyroid carcinoma TT-cell proliferation and secretion of calcitonin and calcitonin gene-related peptide. Mol Cell Endocrinol 103:89-94.
9. Seiler N, Sarhan S, Grauffel C, Jones R, Knogden B, Moulinoux JPH 1990 Endogenous and exogenous polyamines in support of tumor cell growth. Cancer Res 50:5077-5083.
10. Heby O, Holm I, Persson L 1990 Polyamine-mediated control of ornithine decarboxylase and S-adenosylmethionine decarboxylase expression in mammalian cells. Biochem Soc Trans 18:1084-1087.
11. Shantz LM, Pegg AE 1994 Overproduction of ornithine decarboxylase caused by relief of translational repression is associated with neoplastic transformation. Cancer Res 54: 2313-2316.
12. Auvinen M, Paasinen A, Anderson LC, Holtta E 1992 Ornithine decarboxylase activity is critical for cell transformation. Nature 360:355-358.
13. Mori M, Honda M, Shibuta K, et al 1996 Expression of ornithine decarboxylase mRNA in gastric carcinoma. Cancer 77:1634-1638.
14. O'Brein TG, Megosh LC, Gilliard G, Soler AP 1997 Ornithine decarboxylase overexpression is a sufficient condition for tumor promotion in mouse skin. Cancer Res 57:2630-2637.
15. Berdinskikh NK, Ignatenko NA, Zaletok SP, Ganina KP, Chorniy VA 1991 Ornithine decarboxylase activity and polyamine content in adenocarcinomas of human stomach and large intestine. Int J Cancer 47:496-498.
16. Shirihata A, Takahashi N, Beppu T, Hosoda H, Samejima K 1993 Effects of inhibitors of spermidine synthase and spermine synthase on polyamine synthesis. Biochem Pharmacol 45:1897-1903.
17. Marton LJ, Pegg AE 1995 Polyamines as targets for therapeutic intervention. Annu Rev Pharmacol Toxicol 35:55-91.
18. Pegg AE 1994 Ornithine decarboxylase: Structure, function and translational regulation. Biochem Soc Trans 22:846-852.
19. Porter CW, Sufrin JR 1986 Interference with polyamine biosynthesis and/or function by analogs of polyamines or methionine as potential anticancer chemotherapeutic strategy. Anticancer Res 6:525-542.
20. Feige JJ, Chambaz EM 1985 Polyamine uptake by bovine adrenocortical cells. Biochim Biophys Acta 846:93-100.
21. Pohjenpelto P 1976 Putrescine transport is greatly increased in human fibroblasts initiated to proliferate. J Cell Biol 68: 512-520.
22. Porter CW, Ganis B, Rustum Y, Wrsozek Y, Kramer DL, Bergeron RJ 1994 Collateral sensitivity of human melanoma multidrug-resistant vairants to polyamine analogue, N1,N11-diethylnorspermine. Cancer Res 54:5917-5924.
23. Davidson NE, Mank AR, Prestigiacomo LJ, Bergeron RJ, Casero RAJ 1993 Growth inhibition of hormone-responsive and -resistant human breast cancer cells in culture by N1,N12-bis(ethyl)spermine. Cancer Res 53:2071-2075.
24. Aziz SM, Gillespie MN, Crooks PA, et al 1996 The potential of a novel polyamine transport inhibitor in cancer chemotherapy. J Pharmacol Exp Therap 278:185-192.
25. Endean E, Aziz SM, Ain KB, Gillen G, Lipke DW 1995 The antineoplastic effects of polyamine transport inhibitor in cultured thyroid cancer cells. FASEB J 9:A94.
26. Ain KB 1998 Anaplastic thyroid carcinoma: Behavior, biology, and therapeutic approaches. Thyroid 8:715-726.
27. Arnould R, Dubois J, Abikhalil F, et al 1990 Comparison of two cytotoxic assays -tetrazolium derivative reduction (MTT) and tritiated thymidine uptake- on three malignant mouse cell lines using chemotherapeutic agents and investigational drugs. Anticancer Res 10:145-154.
28. Attia MA, Weiss DW 1966 Immunology of spontaneous mammary carcinomas in mice. V. Acquired tumor resistance and enhancement of strain-A mice injected with mammary tumor virus. Cancer Res 26:1787-1800.
29. Aziz SM, Olson JW, Gillespie MN 1994 Multiple polyamine transport pathways in cultured pulmonary artery smooth muscle cells: regulation by hypoxia. Am J Respir Cell Mol Biol 10:160-166.
30. Morgan DM. Polyamine protocols. (First ed.) Totowa, New Jersey: Humana Press, 1998:1-183. (Walker JM, ed. Methods in Molecular Biology; vol 79).
31. Morgan DM. Polyamine protocols. (First ed.) Totowa, New Jersey: Humana Press, 1998:1-183. (Walker JM, ed. Methods in Molecular Biology; vol 79).
32. Smith LL, Wyatt I, Cohen GM 1982 The accumulation of diamines and polyamines into rat lung slices. Biochem Pharmacol 31:3029-3033.
33. Kabra PM, Lee HK, Lubich WP, Marton LJ 1986 Solid-phase extraction and determination of dansyl derivatives of unconjugated and conjugated polyamines by reverse-phase liquid chromatography: Improved separation systems for polyamines in cerebrospinal fluid, urine and tissue. J Chromatog 380:19-32.
34. Aziz SM, Gosland MP, Crooks PA, Olson JW, Gillespie MN 1995 A novel polymeric spermine conjugate inhibits polyamine transport in pulmonary artery smooth muscle cells. J Pharmacol Exp Ther 274:181-186.
35. Russel D, Snyder SH 1968 Amine synthesis in rapidly growing tissues: Ornithine decarboxylase activity in regenerating rat liver, chick embryo and various tumors. Proc Natl Acad Sci USA 60:1420-1427.
36. Murakami Y, Marumo M, Hayashi SI 1988 Ornithine decarboxylase antizyme in kidneys of male and female mice. Biochem J 254:367-372.
37. Rubinstein LV, Shoemaker RH, Paull KD, et al 1990 Comparison of in vitro anticancer-drug-screening data generated with tetrazolium assay versus a protein assay against a diverse panel of human tumor cell lines. J Natl Cancer Inst 82:1113-1118.
38. Monks A, Scudiero D, Skehan P, et al 1991 Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines. J Natl Cancer Inst 83:757-766.
39. Mosmann T 1983 Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxic assays. J Immunol Methods 65:55-61.
40. Tabor H, Tabor CW. 1983 Polyamines. Academic Press, Inc., New York, pp 3-25.
41. Touchstone JC 1992 Practice of thin layer chromatography. Wiley, New York, pp 128-198.
42. Wettlaufer SH 1988 Quantitation of polyamines using thin-layer chromatography and image analysis. J Chromatogr 441: 361-366.
43. Dunnett CW 1964 New tables for multiple comparisons with a control. Biometrics 20:482-491.
44. Kramer DL, Miller JT, Bergeron RJ, Khomutov A, Porter CW 1993 Regulation of polyamine transport by polyamines and polyamine analogs. J Cell Physiol 155:399-407.
45. Mamont PS, Duchesne MC, Grove J, Bey P 1978 Antiproliferative properties of DL-α-difluoromethylornithine in cultured cells. A consequence of the irreversible inhibition of ornithine decarboxylase. Biochem Biophysical Res Commun 81: 58-66.
46. 8-bis(ethyl)-spermidine, an apparent regulator of the enzyme. Cancer Res 46:6279-6285.
47. Harari PM, Pichart MA, Contreras L, Petereit DG, Basu HS, Marton LJ 1995 Slowing proliferation in head and neck tumors: In vitro growth inhibitory effects of the polyamine analog BE-4-4-4-4 in human squamous cell carcinomas. Int J Radiation Oncology Biol Phys 32:687-694.
48. Badolo L, Gelbcke M, Dubois J, Hanocq M 1998 Synthesis and cytotoxicity studies of new analogues of polyamines. Pharmazie 53(1):15-19.
49. Mens T, Tomasi S, Eifler-Lima VL, Uriac P, Huet J, Catros-Quemener V 1997 Inhibition of tumor growth and polyamine uptake by tetracyclic amidines bearing a putrescine moiety. Anticancer Res 17:4327-4332.
50. Pegg AE, Nagarajan S, Naficy S, Ganem B 1991 Role of unsaturated derivatives of spermidine as substrates for spermine synthase and in supporting growth of SV-3T3 cells. Biochem J 274:167-171.
51. Nagajaran S, Ganem B, Pegg AE 1988 Studies of non-metabolizable polyamines that support growth of SV-3T3 cells depleted of natural polyamines by exposure to α-difluoromethylornithine. Biochem J 254:373-378.
52. Lakanen JR, Coward JK, Pegg AE 1992 α-Methyl polyamines: metabolically stable spermidine and spermine mimics capable of supporting growth in cells depleted of polyamines. J Med Chem 35:724-734.
53. Pegg AE 1988 Polyamine metabolism and its importance in neoplastic growth and as a target for chemotherapy. Cancer Res 48:759-774.
54. Bergeron RJ, McManis JS, Liu CZ, et al 1994 Antiproliferative properties of polyamine analogs: A structure-activity study. J Med Chem 37:3464-6476.
55. Lessard M, Zhao C, Singh SM, Poulin R 1995 Hormonal and feedback regulation of putrescine and spermidine transport in human breast cancer cells. J Biol Chem 270:1685-1694.
56. Bergeron RJ, McManis JS, Weimar WR, et al 1995 The role of charge in polyamine analogue recognition. J Med Chem 38:2278-2285.
57. Morris DR 1991 A new perspective on ornithine decarboxylase regulation: prevention of polyamine toxicity as the overriding theme. J Cell Biochem 46:102-105.
58. Mitchell JL, Choe CY, Judd GG 1996 Feedback repression of ornithine decarboxylase synthesis mediated by antizyme. Biochem J 320:755-760.
59. Hayashi SI, Murakami Y 1995 Rapid and regulated degradation of ornithine decarboxylase. Biochem J 306:1-10.
60. Mitchell JL, Judd GG, Bareyal-Leyser A, Ling SY 1994 Feedback repression of polyamine transport is mediated by antizyme in mammalian tissue culture cells. Biochem J 299: 19-22.
61. He Y, Suzuki T, Kashiwagi K, Igarashi K 1994 Antizyme delays the restoration by spermine of growth of polyamine-deficient cells through its negative regulation of polyamine transport. Biochem Biophys Res Commun 203:608-614.
62. 1-acetyltransferase - The turning point in polyamine metabolism. FASEB J 7:653-661.
63. Gahl WA, Pitot HC 1982 Polyamine degradation in foetal and adult bovine serum. Biochem J 202:603-611.
64. Kimes BW, Morris DR 1971 Inhibition of nucleic acid and protein synthesis in Escherichia coli by oxidized polyamines and acreloin. Biochim Biophys Acta 228:235-244.
65. Satake S, Sugawara I, Watanabe M, Takami H 1997 Lack of a point mutation of human DNA topoisomerase II in multidrug-resistant anaplastic thyroid carcinoma cell lines. Cancer Lett 116:33-39.
66. Twentyman PR, Versantvoort CHM 1996 Experimental modulation of MRP (multidrug resistance-associated protein)-mediated resistance. Eur J Cancer 32A:1002-1009.
67. Aziz SM, Worthen DR, Yatin M, Ain KB, Crooks PA 1998 A unique interaction between polyamine and multidrug resistance (P-glycoprotein) transporters in cultured Chinese hamster ovary cells transfected with mouse mdr-1 gene. Biochem Pharmacol 56:181-187.
68. Gosland MP, Gillespie MN, Tsuboi CM, et al 1996 Reversal of doxorubicin, etopside, vinblastine, and taxol resistance multidrug resistant human cells by a polymer of spermine. Chemother Pharmacol 37:593-600.