The role of water molecules in the deacylation of acylated structures of class A β-Lactamase

Drug Design and Discovery

Volumn 16, Issue 2, 1999, Pages 131-143

  Ishiguro, Masaji ^a   Imajo, Seiichi ^a  

^a SUNTORY INSTITUTE FOR BIOORGANIC RESEARCH   (Japan)

Author keywords

lactamase; Hydrolytic mechanism; Molecular dynamics; Penem; Water molecule

Indexed keywords

ANTIBIOTIC AGENT; BETA LACTAMASE; PENEM DERIVATIVE; PENICILLIN G; WATER;

ACYLATION; ARTICLE; CONFORMATIONAL TRANSITION; DEACYLATION; DRUG MECHANISM; DRUG PROTEIN BINDING; ENZYME CONFORMATION; MOLECULAR DYNAMICS;

ACYLATION; ANIONS; BETA-LACTAMASES; CRYSTALLOGRAPHY; MODELS, CHEMICAL; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; SOLUBILITY; WATER;

EID: 0032819979     PISSN: 10559612     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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