메뉴 건너뛰기




Volumn 9, Issue 3, 1999, Pages 139-149

Cell culture conditions determine apolipoprotein CIII secretion and regulation by fibrates in human hepatoma hepG2 cells

Author keywords

Apolipoproteins; Fibrates; Gene expression; Peroxisome proliferator activated receptor

Indexed keywords

APOLIPOPROTEIN A2; APOLIPOPROTEIN B; APOLIPOPROTEIN C3; APOLIPOPROTEIN E; FENOFIBRATE; GEMFIBROZIL; HIGH DENSITY LIPOPROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PIRINIXIC ACID; ROSIGLITAZONE; TRIACYLGLYCEROL;

EID: 0032819192     PISSN: 10158987     EISSN: None     Source Type: Journal    
DOI: 10.1159/000016311     Document Type: Article
Times cited : (36)

References (45)
  • 1
    • 0021704422 scopus 로고
    • Plasma lipoprotein: Apolipoprotein structure and function
    • Mahley RW: Plasma lipoprotein: Apolipoprotein structure and function. J Lipid Res 1984;25:1277-1294.
    • (1984) J Lipid Res , vol.25 , pp. 1277-1294
    • Mahley, R.W.1
  • 2
    • 0029911704 scopus 로고    scopus 로고
    • Apolipoproteins C-III and E in apoB- and non-apoB-containing lipoproteins in two populations at contrasting risk for myocardial infarction: The ECTIM Study
    • Luc G, Fievet C, Arveiler D, Evans A, Bard JM, Cambien F, Fruchart JC, Ducimetière P: Apolipoproteins C-III and E in apoB- and non-apoB-containing lipoproteins in two populations at contrasting risk for myocardial infarction: The ECTIM Study. J Lipid Res 1996;37:508-517.
    • (1996) J Lipid Res , vol.37 , pp. 508-517
    • Luc, G.1    Fievet, C.2    Arveiler, D.3    Evans, A.4    Bard, J.M.5    Cambien, F.6    Fruchart, J.C.7    Ducimetière, P.8
  • 3
    • 0022971151 scopus 로고
    • Apolipoprotein B metabolism in subjects with deficiency of apolipoproteins C-III and A-I. Evidence that apolipoprotein C-III inhibits catabolism of triglyceride-rich lipoproteins by lipoprotein lipase in vivo
    • Ginsberg HN, Le NA, Goldberg IJ, Gibson JC, Rubinstein A, Wang-Iverson P, Norum R, Brown WV: Apolipoprotein B metabolism in subjects with deficiency of apolipoproteins C-III and A-I. Evidence that apolipoprotein C-III inhibits catabolism of triglyceride-rich lipoproteins by lipoprotein lipase in vivo. J Clin Invest 1986;78:1287-1295.
    • (1986) J Clin Invest , vol.78 , pp. 1287-1295
    • Ginsberg, H.N.1    Le, N.A.2    Goldberg, I.J.3    Gibson, J.C.4    Rubinstein, A.5    Wang-Iverson, P.6    Norum, R.7    Brown, W.V.8
  • 4
    • 0024474642 scopus 로고
    • Apolipoprotein C-II and C-III metabolism in hypertriglyceridemic patients. Effect of a drastic triglyceride reduction by combined diet restriction and fenofibrate administration
    • Malmendier CL, Lontie JF, Delcroix C, Dubois DY, Magot T, De Roy L: Apolipoprotein C-II and C-III metabolism in hypertriglyceridemic patients. Effect of a drastic triglyceride reduction by combined diet restriction and fenofibrate administration. Atherosclerosis 1989; 77:139-149.
    • (1989) Atherosclerosis , vol.77 , pp. 139-149
    • Malmendier, C.L.1    Lontie, J.F.2    Delcroix, C.3    Dubois, D.Y.4    Magot, T.5    De Roy, L.6
  • 5
    • 0031467379 scopus 로고    scopus 로고
    • Fat ingestion is associated with increased levels of apoC-III- and apoE-B-containing lipoprotein particles in humans
    • Dallongeville J, Bauge E, Lebel P, Fruchart JC: Fat ingestion is associated with increased levels of apoC-III- and apoE-B-containing lipoprotein particles in humans. Eur J Clin Invest 1997;27:1055-1060.
    • (1997) Eur J Clin Invest , vol.27 , pp. 1055-1060
    • Dallongeville, J.1    Bauge, E.2    Lebel, P.3    Fruchart, J.C.4
  • 6
    • 0025030698 scopus 로고
    • Hypertrigly-ceridemia as a result of human apolipoprotein CIII gene expression in transgenic mice
    • Ito Y, Azrolan N, O'Connell A, Walsh A, Breslow JL: Hypertrigly-ceridemia as a result of human apolipoprotein CIII gene expression in transgenic mice. Science 1990;249: 790-793.
    • (1990) Science , vol.249 , pp. 790-793
    • Ito, Y.1    Azrolan, N.2    O'Connell, A.3    Walsh, A.4    Breslow, J.L.5
  • 7
    • 0026443622 scopus 로고
    • Mechanism of hypertriglyceridemia in human apo CIII transgenic mice: Diminished VLDL fractional catabolic rate associated with increased apo CIII and reduced apo E on the particles
    • Aalto-Setälä K, Fisher EA, Chen X, Chajek-Shaul T, Hayek T, Zechner R, Walsh A, Ramakrishnan R, Ginsberg HN, Breslow JL: Mechanism of hypertriglyceridemia in human apo CIII transgenic mice: Diminished VLDL fractional catabolic rate associated with increased apo CIII and reduced apo E on the particles. J Clin Invest 1992;90:1889-1990.
    • (1992) J Clin Invest , vol.90 , pp. 1889-1990
    • Aalto-Setälä, K.1    Fisher, E.A.2    Chen, X.3    Chajek-Shaul, T.4    Hayek, T.5    Zechner, R.6    Walsh, A.7    Ramakrishnan, R.8    Ginsberg, H.N.9    Breslow, J.L.10
  • 8
    • 0027989828 scopus 로고
    • Targeted disruption of the apolipoprotein C-III gene in mice results in hypertriglyceridemia and protection from post-prandial hypertriglyceridemia
    • Maeda N, Lee D, Oliver P, Quarford SH, Osada J: Targeted disruption of the apolipoprotein C-III gene in mice results in hypertriglyceridemia and protection from post-prandial hypertriglyceridemia. J Biol Chem 1994;269:23610-23616.
    • (1994) J Biol Chem , vol.269 , pp. 23610-23616
    • Maeda, N.1    Lee, D.2    Oliver, P.3    Quarford, S.H.4    Osada, J.5
  • 9
    • 0025800254 scopus 로고
    • Interaction of LpB:E, LpB:C-III and LpB:C-III:E lipoproteins with the low density lipoprotein receptor on HeLa cells
    • Agnani G, Bard JM, Candelier L, Delattre S, Fruchart JC, Clavey V: Interaction of LpB:E, LpB:C-III and LpB:C-III:E lipoproteins with the low density lipoprotein receptor on HeLa cells. Arteriosclerosis 1991; 11:1021-1029.
    • (1991) Arteriosclerosis , vol.11 , pp. 1021-1029
    • Agnani, G.1    Bard, J.M.2    Candelier, L.3    Delattre, S.4    Fruchart, J.C.5    Clavey, V.6
  • 10
    • 0029018057 scopus 로고
    • Modulation of lipoprotein binding to the LDL receptor by exogenous lipids and apolipoproteins C-I, C-II, C-III and E
    • Clavey V, Lestavel-Delattre S, Copin C, Bard JM, Fruchart JC: Modulation of lipoprotein binding to the LDL receptor by exogenous lipids and apolipoproteins C-I, C-II, C-III and E. Arteriosclerosis 1995;15: 963-971.
    • (1995) Arteriosclerosis , vol.15 , pp. 963-971
    • Clavey, V.1    Lestavel-Delattre, S.2    Copin, C.3    Bard, J.M.4    Fruchart, J.C.5
  • 12
    • 0028237723 scopus 로고
    • Apolipoprotein CIII gene transcription is regulated by a cytokine-inducible NF-kappa B element
    • Gruber PJ, Torres-Rosaro A, Wolak ML, Leff T: Apolipoprotein CIII gene transcription is regulated by a cytokine-inducible NF-kappa B element. Nucleic Acids Res 1994;22: 2417-2422.
    • (1994) Nucleic Acids Res , vol.22 , pp. 2417-2422
    • Gruber, P.J.1    Torres-Rosaro, A.2    Wolak, M.L.3    Leff, T.4
  • 13
    • 0027967732 scopus 로고
    • Transcriptional regulation of the apoC-III gene by insulin in diabetic mice: Correlation with changes in plasma triglycerides levels
    • Chen M, Breslow JL, Li W, Leff T: Transcriptional regulation of the apoC-III gene by insulin in diabetic mice: Correlation with changes in plasma triglycerides levels. J Lipid Res 1994;35:1918-1924.
    • (1994) J Lipid Res , vol.35 , pp. 1918-1924
    • Chen, M.1    Breslow, J.L.2    Li, W.3    Leff, T.4
  • 14
    • 0025092313 scopus 로고
    • Changes in lipoprotein particles defined by their apolipoprotein composition on pravastatin and cholestyramine therapy
    • Bard JM, Parra HJ, Douste-Blazy P, Fruchart JC: Changes in lipoprotein particles defined by their apolipoprotein composition on pravastatin and cholestyramine therapy. J Drug Dev 1990;3:111-115.
    • (1990) J Drug Dev , vol.3 , pp. 111-115
    • Bard, J.M.1    Parra, H.J.2    Douste-Blazy, P.3    Fruchart, J.C.4
  • 17
    • 0028998129 scopus 로고
    • Mode of action of peroxisome proliferators as hypolipidemic drugs. Suppression of apolipoprotein C-III
    • Hertz R, Bishara-Shieban J, Bar-Tana J: Mode of action of peroxisome proliferators as hypolipidemic drugs. Suppression of apolipoprotein C-III. J Biol Chem 1995;270: 13470-13475.
    • (1995) J Biol Chem , vol.270 , pp. 13470-13475
    • Hertz, R.1    Bishara-Shieban, J.2    Bar-Tana, J.3
  • 18
    • 0030766476 scopus 로고    scopus 로고
    • Alterations in lipoprotein metabolism in peroxisome proliferator-activated receptor alpha-deficient mice
    • Peters JM, Hennuyer N, Staels B, Fruchart JC, Fievet C, Gonzalez FJ, Auwerx J: Alterations in lipoprotein metabolism in peroxisome proliferator-activated receptor alpha-deficient mice. J Biol Chem 1997;272: 27307-27312.
    • (1997) J Biol Chem , vol.272 , pp. 27307-27312
    • Peters, J.M.1    Hennuyer, N.2    Staels, B.3    Fruchart, J.C.4    Fievet, C.5    Gonzalez, F.J.6    Auwerx, J.7
  • 19
    • 0023127206 scopus 로고
    • Clofibrate does not induce peroxisomal proliferation in human hepatoma cell lines PLC/ PRF/5 and SK-HEP-1
    • Hertz R, Arnon J, Hoter A, Shouval D, Bar-Tana J: Clofibrate does not induce peroxisomal proliferation in human hepatoma cell lines PLC/ PRF/5 and SK-HEP-1. Cancer Lett 1987;34:263-272.
    • (1987) Cancer Lett , vol.34 , pp. 263-272
    • Hertz, R.1    Arnon, J.2    Hoter, A.3    Shouval, D.4    Bar-Tana, J.5
  • 20
    • 0028817459 scopus 로고
    • Fibrates downregulate apolipoprotein C-III expression independent of induction of peroxisomal acyl coenzyme a oxidase. a potential mechanism for the hypolipidemic action of fibrates
    • Staels B, Vu Dac N, Kosykh VA, Saladin R, Fruchart JC, Dallongeville J, Auwerx J: Fibrates downregulate apolipoprotein C-III expression independent of induction of peroxisomal acyl coenzyme A oxidase. A potential mechanism for the hypolipidemic action of fibrates. J Clin Invest 1995;95:705-712.
    • (1995) J Clin Invest , vol.95 , pp. 705-712
    • Staels, B.1    Vu Dac, N.2    Kosykh, V.A.3    Saladin, R.4    Fruchart, J.C.5    Dallongeville, J.6    Auwerx, J.7
  • 21
    • 0022003749 scopus 로고
    • Effects of oestrogen on apolipoprotein secretion by the human hepatocarcinoma cell line, HepG2
    • Tam PS, Archer TK, Deeley RG: Effects of oestrogen on apolipoprotein secretion by the human hepatocarcinoma cell line, HepG2. J Biol Chem 1985;260:1670-1675.
    • (1985) J Biol Chem , vol.260 , pp. 1670-1675
    • Tam, P.S.1    Archer, T.K.2    Deeley, R.G.3
  • 22
    • 0019813096 scopus 로고
    • Characterization of the major apolipoproteins secreted by two human hepatoma cell lines
    • Zannis VI, Brewslow JL, San Giacomo TR, Aden DP, Knowles BB: Characterization of the major apolipoproteins secreted by two human hepatoma cell lines. Biochemistry 1981;20:7089-7096.
    • (1981) Biochemistry , vol.20 , pp. 7089-7096
    • Zannis, V.I.1    Brewslow, J.L.2    San Giacomo, T.R.3    Aden, D.P.4    Knowles, B.B.5
  • 23
    • 0023101018 scopus 로고
    • Secretion of lipids, apolipoproteins, and lipoproteins by human hepatoma cell line, HepG2: Effects of oleic acid and insulin
    • Dashti N. Wolfbauer G, Secretion of lipids, apolipoproteins, and lipoproteins by human hepatoma cell line, HepG2: Effects of oleic acid and insulin. J Lipid Res 1987;28:423-436.
    • (1987) J Lipid Res , vol.28 , pp. 423-436
    • Dashti, N.1    Wolfbauer, G.2
  • 24
    • 0027531667 scopus 로고
    • Regulation of hepatic secretion of apolipoprotein B-containing lipoproteins: Information obtained from cultured liver cells
    • Dixon JL, Ginsberg HN: Regulation of hepatic secretion of apolipoprotein B-containing lipoproteins: Information obtained from cultured liver cells. J Lipid Res 1993;34:167-179.
    • (1993) J Lipid Res , vol.34 , pp. 167-179
    • Dixon, J.L.1    Ginsberg, H.N.2
  • 25
    • 0029996677 scopus 로고    scopus 로고
    • Inhibition of apolipoprotein B and triglyceride secretion in human hepatoma cells (HepG2)
    • Haghpassand M, Wilder D, Moberly JB: Inhibition of apolipoprotein B and triglyceride secretion in human hepatoma cells (HepG2). J Lipid Res 1996;37:1468-1480.
    • (1996) J Lipid Res , vol.37 , pp. 1468-1480
    • Haghpassand, M.1    Wilder, D.2    Moberly, J.B.3
  • 26
    • 0029923178 scopus 로고    scopus 로고
    • Human HepG2 and rat Fao hepatic-derived cell lines show different responses to ciprofibrate, a peroxisome proliferator: Analysis by flow cytometry
    • Passilly P, Jannin B, Hassel SJ, Latruffe N: Human HepG2 and rat Fao hepatic-derived cell lines show different responses to ciprofibrate, a peroxisome proliferator: Analysis by flow cytometry. Exp Cell Res 1996; 223:436-442.
    • (1996) Exp Cell Res , vol.223 , pp. 436-442
    • Passilly, P.1    Jannin, B.2    Hassel, S.J.3    Latruffe, N.4
  • 27
    • 0026636624 scopus 로고
    • Transcriptional regulation of human apolipoprotein genes apoB, apoCIII, and apoAII by members of the steroid hormone receptor superfamily HNF-4, ARP-1, EAR-2, and EAR-3
    • Ladias JA, Hadzopoulou-Cladaras M, Cardot P, Cheng J, Zannis VI, Cladaras C: Transcriptional regulation of human apolipoprotein genes apoB, apoCIII, and apoAII by members of the steroid hormone receptor superfamily HNF-4, ARP-1, EAR-2, and EAR-3. J Biol Chem 1992; 267:15849-15860.
    • (1992) J Biol Chem , vol.267 , pp. 15849-15860
    • Ladias, J.A.1    Hadzopoulou-Cladaras, M.2    Cardot, P.3    Cheng, J.4    Zannis, V.I.5    Cladaras, C.6
  • 28
    • 0028805096 scopus 로고
    • A sensitive method to analyze in vitro secretion of lipoproteins: Distribution of apolipoproteins is modulated by oleic acid in HepG2 cells
    • Benoist F, Grand-Perret T: A sensitive method to analyze in vitro secretion of lipoproteins: Distribution of apolipoproteins is modulated by oleic acid in HepG2 cells. J Lipid Res 1995;36:2243-2250.
    • (1995) J Lipid Res , vol.36 , pp. 2243-2250
    • Benoist, F.1    Grand-Perret, T.2
  • 29
    • 0027052280 scopus 로고
    • Effect of ethanol on lipoprotein secretion in two human hepatoma cell lines, HepG2 and Hep3B
    • Tam SP: Effect of ethanol on lipoprotein secretion in two human hepatoma cell lines, HepG2 and Hep3B. Alcohol Clin Exp Res 1992; 16:1021-1028.
    • (1992) Alcohol Clin Exp Res , vol.16 , pp. 1021-1028
    • Tam, S.P.1
  • 30
    • 0022250146 scopus 로고
    • Quantification of apolipoprotein CIII in serum by noncompetitive immunoenzymometric assay
    • Parsy D, Clavey V, Fievet C, Kora I, Duriez P, Fruchart JC: Quantification of apolipoprotein CIII in serum by noncompetitive immunoenzymometric assay. Clin Chem 1987; 31:1632-1635.
    • (1987) Clin Chem , vol.31 , pp. 1632-1635
    • Parsy, D.1    Clavey, V.2    Fievet, C.3    Kora, I.4    Duriez, P.5    Fruchart, J.C.6
  • 31
    • 0023779461 scopus 로고
    • Characterization of monoclonal antibody that binds to apo E and lipoprotein of human plasma containing apo E. Applications to ELISA quantification of plasma apo E
    • Leroy A, Vu Dac N, Koffigan M, Clavey V, Fruchart JC: Characterization of monoclonal antibody that binds to apo E and lipoprotein of human plasma containing apo E. Applications to ELISA quantification of plasma apo E. J Immunoassay 1988;9:309-334.
    • (1988) J Immunoassay , vol.9 , pp. 309-334
    • Leroy, A.1    Vu Dac, N.2    Koffigan, M.3    Clavey, V.4    Fruchart, J.C.5
  • 32
    • 0022973141 scopus 로고
    • Quantitative determination of human plasma apo-AII by a non-competitive enzyme-linked immunosorbent assay
    • Puchois P, Kandoussi A, Duriez P, Fruchart JC, McConathy WJ, Koren E: Quantitative determination of human plasma apo-AII by a non-competitive enzyme-linked immunosorbent assay. J Immunoassay 1986;7:285-307.
    • (1986) J Immunoassay , vol.7 , pp. 285-307
    • Puchois, P.1    Kandoussi, A.2    Duriez, P.3    Fruchart, J.C.4    McConathy, W.J.5    Koren, E.6
  • 33
    • 84943471599 scopus 로고
    • Standardization of an enzymometric assay for apolipoprotein A-I by using mixtures of monoclonal antibodies
    • Betard C, Vu-Dac N, Mezdour H, Nestruck AC, Leroy A, Fruchart JC: Standardization of an enzymometric assay for apolipoprotein A-I by using mixtures of monoclonal antibodies. J Clin Chem Clin Biochem 1987;25:893-899.
    • (1987) J Clin Chem Clin Biochem , vol.25 , pp. 893-899
    • Betard, C.1    Vu-Dac, N.2    Mezdour, H.3    Nestruck, A.C.4    Leroy, A.5    Fruchart, J.C.6
  • 34
    • 0022968443 scopus 로고
    • Quantitation of human serum apolipoprotein B by enzyme immunoassay in excess antigen
    • Fievet C, Dedieu A, Kandoussi A, Luyeye I, Fruchart JC: Quantitation of human serum apolipoprotein B by enzyme immunoassay in excess antigen. Clin Chim Acta 1986;159: 269-278.
    • (1986) Clin Chim Acta , vol.159 , pp. 269-278
    • Fievet, C.1    Dedieu, A.2    Kandoussi, A.3    Luyeye, I.4    Fruchart, J.C.5
  • 36
    • 0025778925 scopus 로고
    • 36B4 cDNA used as an estradiol-independent mRNA control is the cDNA for human acidic ribosomal phosphoprotein PO
    • Laborda J: 36B4 cDNA used as an estradiol-independent mRNA control is the cDNA for human acidic ribosomal phosphoprotein PO. Nucleic Acids Res 1991;19:3998.
    • (1991) Nucleic Acids Res , vol.19 , pp. 3998
    • Laborda, J.1
  • 37
    • 0026488464 scopus 로고
    • Perturbation of developmental gene expression in rat liver by fibric acid derivatives: Lipoprotein lipase and alpha-feto-protein as models
    • Staels B, Auwerx J: Perturbation of developmental gene expression in rat liver by fibric acid derivatives: Lipoprotein lipase and alpha-feto-protein as models. Development 1992;115:1035-1043.
    • (1992) Development , vol.115 , pp. 1035-1043
    • Staels, B.1    Auwerx, J.2
  • 41
    • 0029016829 scopus 로고
    • An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor-gamma (PPARγ)
    • Lehmann JM, Moore LB, Smith-Oliver TA, Wilkison WO, Willson TM, Kliewer SA: An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor-gamma (PPARγ). J Biol Chem 1995;270: 12953-12956.
    • (1995) J Biol Chem , vol.270 , pp. 12953-12956
    • Lehmann, J.M.1    Moore, L.B.2    Smith-Oliver, T.A.3    Wilkison, W.O.4    Willson, T.M.5    Kliewer, S.A.6
  • 42
    • 0026442356 scopus 로고
    • An in vitro model for essential fatty acid deficiency: HepG2 cells permanently maintained in lipid-free medium
    • Furth EE, Sprecher H, Fisher EA, Fleishman HD, Laposata M: An in vitro model for essential fatty acid deficiency: HepG2 cells permanently maintained in lipid-free medium. J Lipid Res 1992;33:1719-1726.
    • (1992) J Lipid Res , vol.33 , pp. 1719-1726
    • Furth, E.E.1    Sprecher, H.2    Fisher, E.A.3    Fleishman, H.D.4    Laposata, M.5
  • 43
    • 0031776225 scopus 로고    scopus 로고
    • Functional interactions between nuclear receptors recognizing a common sequence element, the direct repeat motif spaced by one nucleotide (DR-1)
    • Tokyo
    • Nishiyama C, Hi R, Osada S, Osumi T: Functional interactions between nuclear receptors recognizing a common sequence element, the direct repeat motif spaced by one nucleotide (DR-1). J Biochem (Tokyo) 1998;123:1174-1179.
    • (1998) J Biochem , vol.123 , pp. 1174-1179
    • Nishiyama, C.1    Hi, R.2    Osada, S.3    Osumi, T.4
  • 44
    • 0032103013 scopus 로고    scopus 로고
    • DNA binding and transcription activation specificity of hepatocyte nuclear factor 4
    • Fraser JD, Martinez V, Straney R, Briggs MR: DNA binding and transcription activation specificity of hepatocyte nuclear factor 4. Nucleic Acids Res 1998;26:2702-2707.
    • (1998) Nucleic Acids Res , vol.26 , pp. 2702-2707
    • Fraser, J.D.1    Martinez, V.2    Straney, R.3    Briggs, M.R.4
  • 45
    • 0030018334 scopus 로고    scopus 로고
    • Characterization of a dominant negative mutant form of the HNF-4 orphan receptor
    • Taylor DG, Haubenwallner S, Leff T: Characterization of a dominant negative mutant form of the HNF-4 orphan receptor. Nucleic Acids Res 1996;24:2930-2935.
    • (1996) Nucleic Acids Res , vol.24 , pp. 2930-2935
    • Taylor, D.G.1    Haubenwallner, S.2    Leff, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.