Oral administration of interferon-α induces a transient decline in oral mucosal immunoglobulins and an increase in interleukin-5

Journal of Interferon and Cytokine Research

Volumn 19, Issue 8, 1999, Pages 953-959

  Naylor, Paul H ^a,b   Naylor, Cartha W ^a   Hendrix, Susan ^a   Leveque, Francis G ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b HARPER UNIVERSITY HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; IMMUNOGLOBULIN A; IMMUNOGLOBULIN M; INTERFERON; INTERLEUKIN 5;

ADULT; ARTICLE; DOSE RESPONSE; DRUG MECHANISM; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMAN EXPERIMENT; IMMUNE SYSTEM; IMMUNOGLOBULIN PRODUCTION; IMMUNOMODULATION; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; OROPHARYNX; PRIORITY JOURNAL; SALIVA;

ADMINISTRATION, ORAL; ADOLESCENT; ADULT; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; IMMUNOGLOBULIN A, SECRETORY; IMMUNOGLOBULINS; INTERFERON TYPE II; INTERFERON-ALPHA; INTERLEUKIN-5; MIDDLE AGED; MOUTH MUCOSA; SALIVA; TIME FACTORS;

ANIMALIA;

EID: 0032818248     PISSN: 10799907     EISSN: None     Source Type: Journal    
DOI: 10.1089/107999099313505     Document Type: Article

References (32)

1. DeMAEYER, E. (1984). Interferons and the immune system. In: Interferon I. Billiau, Amsterdam: Elsevier, pp. 167-188.
2. WITHERSPON, L.R. (1984). The interferons-clinical applications and new technologies. J. Nucl. Med. 25, 817-822.
3. DJEU, J.Y., STOCKS, N., ZOON, K., STANTON, G.J., TIMONEM, T., and HERBERMAN, R.B. (1982). Positive self regulation of cytotoxicity in human natural killer cells by production of interferon upon exposure to influenza and herpes virus. J. Exp. Med. 156, 1222-1228.
4. CANTRELL, K., and PYHALA, L. (1973). Circulating interferon in rabbits after administration of human interferon by different routes. J. Gen. Virol. 20, 97-107.
5. BOCCI, V. (1990). Is interferon effective after oral administration? the state of the art. J. Biol. Regul. Homeostat. Agents 4, 81-83.
6. CUMMINS, J.M., TOMPKINS, M.B., OLSEN, R.G., TOMPKINS, W.A., and LEWIS, M.G. (1988). Oral use of human alpha interferon in cats. J. Biol. Res. Mold. 7, 513-523.
7. STANTON, G.J., HUGHES, T.K., HEARD, H.K., GEORGIADES, J., and WHORTON, E. (1990). Modulation of a natural virus defense system by low concentrations of interferons at mucosal surfaces. J. Interferon Res. 10 (Suppl. 1), S99.
8. HUTCHINSON, V.A., ANGENEND, J.L., MOK, W.L., CUMMINS, J.M., and RICHARDS, A.B. (1990). Chronic recurrent aphthous stomatitis: oral treatment with low-dose interferon alpha. Mol. Biother. 2, 160-164.
9. HUTCHINSON, V.A., MOK, W.L., ANGENEND, J.L., CUMMINS, J.M., and RICHARDS, A.B. (1990). Chronic major aphthous stomatitis: oral treatment with low-dose α-interferon. Mol. Biother. 2, 217-220.
10. LEVEQUE, F.G., AL-SARRAF, M., KISH, J., CUMMINS, M., and RICHARDS, A. (1998). Low dose human interferon alpha (HuIFN-α) to treat mucositis induced by chemotherapy. Proc. Am. Assoc. Cancer Res., Abstr. #3443.
11. SALAZAR-MATHER, T.P., ISHIKAWA, R., and BIRON, C.A. (1996). NK cell trafficking and cytokine expression in splenic compartments after IFN induction and viral infection. J. Immunol. 157, 3054-3064.
12. TOUGH, D.F., BORROW, P., and SPRENT, J. (1996). Induction of bystander T cell proliferation by viruses and type 1 interferon in vivo. Science 272, 1947-1950.
13. AHMED, R. (1996). Tickling memory T cells. Science 272, 1904.
14. ULICH, T.R., WATSON, L.R., YIN, S., GUO, K., WANG, P., THANG, H., and CASTILLO, J.D. (1991). The intratracheal administration of endotoxin and cytokines. 1. Characterization of LPSinduced IL-1 and TNF mRNA expression in the LPS, IL-1 and TNFinduced inflammatory infiltrate. Am. J. Pathol. 138, 1485-1496.
15. TANG, W.W., YI, E.S., REMICK, D.G., WHITTWER, A., YIN, S., QI, M., and ULICH, T.R. (1995). Intratracheal injection of endotoxin and cytokines. IX. Contribution of CD1 la/lCAM-1 to neutrophil emigration. Am. J. Physiol. 265(5, Pt 1), L653-659.
16. DIEZ, R.A., PEREDEREAU, B., and FALCOFF, E. (I987). From old results to new perspectives: A look at interferon's fate in the body. J. Interferon Res. 7, 553-557.
17. SHIOZAWA, S., SHIOZAWA, K., SHIMIZU, S., TANAKA, Y., MORIMOTO, I., YOSHIHARA, R., KUROKI, Y., HASHIMOTO, M., and FUJITA, T. (1990). Immunoreactive circulating alpha interferon is low in Sjögren's syndrome. Br. J. Rheum. 29, 50-52.
18. SHIOZAWA, S., MORIMOTO, I., TANAKA, Y., and SHIOZAWA, K. (1993). A preliminary study on interferon-α treatment for xerostomia of Sjögren's syndrome. Br. J. Rheum. 32, 52-53.
19. SHIOZAWA, S., TANAKA, Y., and SHIOZAWA, K. (1998). Single-blinded controlled trial of low dose IFN α for the treatment of xerostomia in Sjögren's syndrome. J. Interferon Cytokine Res. 18, 255-262.
20. MOLDAWER, N.P., and FIGLIN, R.A. (1995). The interferons. In: Biotherapy. Rieger, London: Jones and Bartlett Publishers, pp. 69-92.
21. KEILHOLZ, U., SCHEIBENBOGEN, C., TILGEN, W., et al (1993). Interferon-alpha and interleukin-2 in the treatment of metastatic melanoma. Comparison of two phase II trials. Cancer 72, 607-614.
22. MOGI, G. (1975). Secretory immunoglobulin A in oral and respiratory passages in man. Ann. Otol. Rhinol. Laryngol. 84 (Suppl. 20, 3 Part 2), 1-23.
23. SATO, K. (1991). Enzyme-linked immunosorbent assay of SigA in whole saliva of healthy subjects and patients with oral diseases. Bull. Tokyo Med. Dent. Univ. 38, 9-18.
24. CRAWFORD, J.M., TAUBMAN, M.A., and SMITH, D.J. (1975). Minor salivary glands as a major source of secretory immunoglobulin A in the human oral cavity. Science 190, 1206-1209.
25. ABBAS, A.K., LICHTMAN, A.H., and POBER, J.S. (1994). Antibodies and antigens. In: Cellular and Molecular Immunology. Philadelphia: WB Saunders, pp. 54-55.
26. IZUTSU, K.T., MENARD. T.W., SCHUBERT, M.M., ENSIGN, W.Y., SULLIVAN, K., TRUELOVE, E.L., and THOMAS, E.D. (1985). Graft versus host disease-related secretory immunoglobulin A deficiency in bone marrow transplant recipients. Findings in labial saliva. Lab. Invest. 52, 292-297.
27. JEMMOTT, J.B., BORYSENKO, J.Z., BORYSENKO, M., McCLELLAND, D.C., CHAPMAN, R., MEYER, D., and BENSON, H. (1983). Academic stress, power motivation, and decrease in secretion rate of salivary secretory immunoglobulin. A. Lancet 8339, 1400-1402.
28. OTTEN, H.G., DAHA, M.R., VANLAAR, J.M., DE ROOY, H.H., and BREEDVELD, F.C. (1991). Subclass distribution and size of human IgA rheumatoid factor at mucosal and nonmucosal sites. Arthritis Rheum. 34, 831-839.
29. NAHIR, A.M., SZARGEL, R., SCHARF, J., BEN-ARYEH, H., LAUBER, D., and SCHARF, Y. (1987). Chemical analysis of whole saliva in Sjögren's syndrome. Ann. Rheum. Dis. 46, 654-657.
30. ABBAS, A.K., LICHTMAN, A.H., and POBER, J.S. (1994). Functional anatomy of local and systemic immune responses. In: Cellular and Molecular Immunology. Philadelphia: WB Saunders, pp. 232-235.
31. MESTECKY, J. (1987). The common mucosal immune system and current strategies for induction of immune responses in external secretions. J. Clin. Immunol. 7, 265-276.
32. ROSTOKER, G., TERZIDID, H., PETIT-PHAR, M., LANG, P., and WEIL, B. (1995). Study of salivary and serum secretory IgA mesangial nephritis and primary glomerulonephritis. Adv. Exp. Med. Biol. 371, 835-837.