Glucocorticoid-dependent impairment of wound healing in experimental diabetes: Amelioration by adrenalectomy and RU 486

Journal of Surgical Research

Volumn 82, Issue 2, 1999, Pages 234-243

  Bitar, Milad S ^a   Farook, Thameem ^a   Wahid, Sabah ^a   Francis, Issam M ^a  

^a KUWAIT UNIVERSITY   (Kuwait)

Author keywords

Adrenalectomy; Diabetes mellitus; Impaired wound healing; RU 486

Indexed keywords

GLUCOCORTICOID; INSULIN; MIFEPRISTONE; POLYVINYL ALCOHOL SPONGE;

ADRENALECTOMY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COLLAGEN METABOLISM; CONTROLLED STUDY; DIABETES MELLITUS; HYPERCORTISOLISM; MALE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RAT; SKIN INCISION; STREPTOZOCIN DIABETES; TENSILE STRENGTH; WOUND HEALING;

EID: 0032818026     PISSN: 00224804     EISSN: None     Source Type: Journal    
DOI: 10.1006/jsre.1998.5541     Document Type: Article

References (55)

1. Rosenthal S. P. Acceleration of primary wound healing by insulin. Arch. Surg. 96:1968;53.
2. Prokash M. K., Sharma L. K. Studies in wound healing in experimental diabetes. Int. Surg. 59:1974;25.
3. Goodson W. H., Hunt T. K. Wound healing and the diabetic patient. Surg. Gynecol. Obstet. 149:1979;600.
4. Yue D. K., McLennan S., Marsh Mand. Effects of experimental diabetes uremia and malnutrition on wound healing. Diabetes. 36:1987;295.
5. Fahey T. J., Sadaty A., Jones W. G., Barber A., Smoller B., Shires G. T. Diabetes impairs the late inflammatory response to wound healing. J. Surg. Res. 50:1991;308.
6. Goodson W. H., Hunt T. K. Studies of wound healing in experimental diabetes. J. Surg. Res. 22:1977;221.
7. Andreassen T. T., Oxlund H. The influence of experimental diabetes and insulin treatment of the biochemical properties of rat skin incisional wounds. Acta Chir. Scand. 153:1987;405.
8. Bitar M. S., Labbad Z. N. Transforming growth factor beta and insulin-like growth factor-1 in relation to diabetes-induced impairment of wound healing. J. Surg. Res. 61:1996;113.
9. Bitar M. S. Insulin-like growth factor-1 reverses diabetes-induced wound healing impairment in rats. Horm. Metab. Res. 29:1997;383.
10. Sandberg N. Time relationship between administration of cortisone and wound healing in rats. Acta Chir. Scand. 127:1964;446.
11. McNamara J. J., Lamborn P. J., Mills D. M., Abby G. V. Effect of short term pharmacological doses of adrenocorticosteroid therapy on wound healing. Ann. Surg. 170:1969;199.
12. Ehrlich H. P., Hunt T. K. Effects of corticosterone and vitamin A on wound healing. Ann. Surg. 167:1968;324.
13. Smith K. P., Zardiackas L. D., Didlake R. Cortisone, vitamin A and wound healing: The importance of measuring wound surface area. J. Surg. Res. 40:1986;120.
14. Hunt T. K., Ehrlich H. P., Garcia J. A., Durphy J. E. Effect of vitamin A on reversing the inhibitory effect of corticosterone on healing of open wounds in animals and men. Ann. Surg. 170:1969;633.
15. Dostal G. M., Gamelli R. L. The differential effects of corticosteroids on wound disruption strength in mice. Arch. Surg. 125:1990;636.
16. Goforth P., Gudes C. J. Effects of steroids on wound healing: A review of the literature. J. Foot Surg. 19:1980;22.
17. Shulimson A. D., Lawrence P. F., Lacono C. U. Diabetic ulcers: The effect of thermal biofeedback-mediated relaxation training on healing. Biofeedback and self-regulation. Regulation. 11:1988;311.
18. Bitar, M. S. Glucocorticoid dynamics and impaired wound healing in diabetes mellitus, Am. J. Pathol. 152, 547.
19. Cameron O. G., Thomas B., Tiongeo D., Greden J. Hyper-cortisolism in diabetes mellitus. Diabetes Care. 10:1987;662.
20. Roy M., Collier B., Roy A. Hypothalamic-pituitary adrenal axis dysregulation among diabetic outpatients. Psychol. Res. 31:1990;31.
21. Knox W. F., Auerback V. H. The hormonal control of tryptophan peroxidase in the rat. J. Biol. Chem. 214:1995;307.
22. Gjerde H., Morland J., Olsen H. The antiglucocorticoid RU 486 inhibits the ethanol-induced increase of tryptophan oxygenase. J. Steroid Biochem. 23:1985;1091.
23. Woessner J. F. Jr. The determination of hydroxyproline in tissue and protein samples containing small preparations of this imino acid. Arch. Biochem. Biophys. 93:1961;440.
24. Genovese C., Rowe D., Kream B. Construction of DNA sequences complementary to rat alpha-1 and alpha-2 collagen mRNA and their use in studying the regulation of the type I collagen synthesis by 1,25-dihydroxy vitamin D. Biochemistry. 23:1984;6210.
25. Frankel F. R., Hsu C. Y., Myers J. C., Lin E., Lyttle C. R., Komm B., Mohn K. Regulation of alpha-2(I), alpha-1(III) and alpha-2(V) collagen mRNA by estradiol in the immature rat uterus. DNA. 7:1988;347.
26. Montagna W., Carliste K. S., Brenner R. M. Histological techniques for the study of granular cells during wound healing. Am. J. Dermatopathol. 9:1987;26.
27. 1. Am. J. Pathol. 140:1992;1375.
28. Levenson S. M., Geever E. F., Crowley L. V., Oates J. F., Berard C. W., Rosen H. The healing of rat skin wounds. Ann. Surg. 161:1965;293.
29. Yagihashi S. Pathology and pathogenetic mechanisms of diabetic neuropathy. Diabetes Metab. Rev. 11:1995;193.
30. Brown M. R., Dyck P. J., McClearn G. E., Sima A. P. F., Powell H. C., Porte D. J. Central and peripheral nervous system complications. Diabetes. 31:1982;65.
31. Thomas P. K. Diabetic neuropathy: Human and experimental. Drugs. 32:1986;36.
32. Riedy M. C., Timm E. A. Jr., Stewart C. C. Quantitative RT-PCR for measuring gene expression. BioTechniques. 18:1995;70.
33. Gilliland G., Perrin S., Blanchard K., Bunn H. F. Analysis of cytokine mRNA and DNA: Detection and quantitation by competitive polymerase chain reaction. Proc. Natl. Acad. Sci. USA. 87:1990;2725.
34. Wuarin L., Guertin D. M., Ishil D. N. Early reduction in insulin-like growth factor expression in diabetic nerve. Exp. Neurol. 130:1994;106.
35. McMurray J. F. Wound healing with diabetes mellitus. Surg. Clin. North Am. 64:1984;769.
36. Arguilla E. R., Weringer E. J., Nakajo M. Wound healing, a model for the study of diabetic angiopathy. Diabetes. 25:1976;811.
37. Axelrod L. Infections in diabetic patients. Clin. Diabetes. 3:1985;98.
38. Silhi N. Diabetes and wound healing. J. Wound Care. 7:1998;47.
39. Bashey R. L., Perlish J. S., Fleischmayer R. Stimulation of collagen synthesis in embryonic chick skin by insulin. Connect. Tissue Res. 1:1972;189.
40. Mikkonen L., Sampiaho K., Kulonen E. Effect of thyroid hormones, somatotrophin, insulin and corticosteroids on synthesis of collagen in granulation tissue both in vivo and in vitro. Acta Endocrinol. 51:1966;23.
41. Hayashi T., Nagai Y. Factors affecting the interactions of collagen molecules as observed by in vitro fibril formation. J. Biochem. 72:1972;749.
42. Bagdade J. D., Neilson K. L., Bulger R. J. Reversible abnormalities in phagocytic function in poorly controlled diabetes. Am. J. Med. Sci. 263:1972;451.
43. Chittenden S. J., Skhani S. K. Microangiopathy in diabetes mellitus. 1. Causes, prevention and treatment. Diabetes Res. 17:1991;105.
44. Spanheimer R. G., Umpierrez G. E., Stumf V. Decreased collagen production in diabetic rats. Diabetes. 37:1988;371.
45. Spanheimer, R. G. Direct inhibition of collagen production in vitro by diabetic rat serum, Metabolism, 37, 479.
46. Lien Y. H., Stern R., Fu J. C. C., Siegel R. Inhibition of collagen fibril formation in vitro and subsequent crosslinking by glucose. Science. 225:1984;1489.
47. Bennett N. T., Schultz G. S. Growth factors and wound healing. Part II. Role in normal and chronic wound healing. Am. J. Surg. 166:1993;74.
48. Bertagan X., Bertagan C., Luton J. P., Husson J. P., Girard F. The new steroid analog RU 486 inhibits glucocorticoid actions in man. J. Clin. Endocrinol. Metab. 59:1984;25.
49. Jung-Testas I., Baulieu E. E. Inhibition of glucocorticoid action in cultured L-929 mouse fibroblasts by RU 486, a new antiglucocortcoid of high affinity for the glucocortiocoid receptor. Exp. Cell Res. 147:1983;177.
50. Moguilewsky M., Philibert D. RU 38486: Potent antiglucocorticoid activities correlated with strong binding to the cytosolic glucocorticoid receptor followed by an impaired activation. J. Steroid Biochem. 20:1984;271.
51. Chrousos G. P., Lauc C., Nieman L. K. Glucocorticoids and glucocorticoid antagonists: Lessons from RU 486. Kidney Int. 34:1988;S18.
52. Madden J. W., Peacock E. E. Studies on the biology of collagen during wound healing. III. Dynamic metabolism of scar collagen and remodeling of dermal wounds. Ann. Surg. 174:1971;511.
53. Nieman L. K., Chrousos G. P., Kellner C. Successful treatment of Cushing's syndrome with the glucocorticoid antagonist RU 486. J. Clin. Endocrinol. Metab. 61:1985;536.
54. Chomczynski P., Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate phenol-chloroform extraction. Anat. Biochem. 162:1987;156.
55. Engesaeter L. B., Skar A. G. Effects of tetracycline on the mechanical properties of bone and skin in young rats. Acta. Orthop. Scand. 49:1978;529.