Diminished interferon-gamma (IFN-γ) production by bacterial antigen-specific T cells in atopic patients

Clinical and Experimental Immunology

Volumn 106, Issue 1, 1996, Pages 62-66

  Shimojo, N ^a,b   Kohno, Y ^a   Katsuki, T ^a   Hoshioka, A ^a   Honma, K ^a   Saito, K ^a   Niimi, H ^a  

^a CHIBA UNIVERSITY   (Japan)

^b SHIMOSHIZU HOSPITAL   (Japan)

Author keywords

Atopy; Healthy; Interferon gamma; PPD specific T cell line

Indexed keywords

ALLERGEN; BACTERIAL ANTIGEN; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 4; PHORBOL ESTER; TUBERCULIN;

ADULT; ARTICLE; ASTHMA; ATOPIC DERMATITIS; ATOPY; CASE REPORT; CONTROLLED STUDY; DERMATOPHAGOIDES FARINAE; HUMAN; HUMAN CELL; IMMUNOREGULATION; MYCOBACTERIUM TUBERCULOSIS; PRIORITY JOURNAL; T LYMPHOCYTE;

EID: 0029738622     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.1996.d01-816.x     Document Type: Article

References (23)

1. Mosmann TR, Cerwinski H, Bond MW et al. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol 1986; 136:2348 57.
2. Wierenga EA, Snoek M, Jansen HM, Bos JA, van Lier RWA, Kapsenberg ML. Human atopen-specific types 1 and 2 T helper cell clones. J Immunol 1991; 147:2942 9.
3. Leung DYM, Geha RS. Immunoregulatory abnormalities in atopic dermatitis. Clin Rev Allergy 1986; 4:67 86.
4. Reinhold U, Wehrmann W, Kukel S et al. Evidence that defective interferon-gamma production in atopic dermatitis patients is due to intrinsic abnormalities, Clin Exp Immunol 1990; 79:374 9.
5. Rousset F, Robert J, Andary M et al. Shifts in interleukin-4 and interferon-γ Production by T cells of patients with elevated serum IgE levels and the modulatory effects of these cytokines on spontaneous IgE synthesis. J Allergy Clin Immunol 1991; 87:58 69.
6. Jujo K, Renz, H, Abe J et al. Decreased interferon-gamma and increased interleukin-4 production in alopic dermatitis promotes IgE synthesis. J Allergy Clin Immunol 1992; 90:323 31.
7. + T lymphocytes in atopic patients. J Immunol 1990; 144:651 6.
8. Maggi E, Parronchi P, Manetti R et al. Reciprocal regulatory effects of IFN-γ and IL-4 on the in vitro development of human Th1 and Th2 clones. J Immunol 1992; 148:2142 7.
9. Parronchi P, Macchia D, Piccini MP et al. Allergen- and bacterial-specific T-cell clones established from atopic donors show a different profile of cytokine production. Proc Natl Acad Sci USA 1991; 88:4538 42.
10. Shimojo N, Katsuki T, Saito K et al. Thyroglobulin-specific T cell line from a healthy individual does not produce proinflammatory cytokines on antigenic stimulation: an implication for possible fail safe mechanism to avoid autoimmunity. Autoimmunity 1994; 17:203 7.
11. Jung T, Lack G, Schauer U et al. Decreased frequency of interferon-γ- and interleukin-2-producing cells in patients with atopic diseases measured at the single cell level. J Allergy Clin Immunol 1995; 96:515 27.
12. + T cell clones. J Immunol 1992; 148:738 45.
13. Shimojo N, Katsuki T, Coligan JE et al. Identification of the disease-related T cell epitope of ovalbumin and epitope-targeted T cell inactivation in egg allergy. Int Arch Allergy Immunol 1994; 105:155 61.
14. Katsuki T, Shimojo N, Honma K, Tsunoo H, Kohno Y, Niimi H. Establishment and characterization of ovalbumin-specific T cell lines from patients with egg allergy. Int Arch Allergy Immunol 1996; 109:344 51.
15. + T cell lines. J Allergy Clin Immunol 1996; 97:1342 9.
16. Looney RJ, Pudiak D, Rosenfeld SI. Cytokine production by mite-specific T cells from donors with mild atopic disease. J Allergy Clin Immunol 1994; 93:476 83.
17. Matsumoto K, Taki F, Miura M et al. Serum levels of soluble IL-2R, IL-4, and soluble Fee RII in adult bronchial asthma. Chest 1994; 105:681 6.
18. Swain SL, Weinberg AD. English M et al. IL-4 directs the development of Th2-like helper effectors. J Immunol 1990; 145:3796 806.
19. Kullberg MC, Pearce EJ, Hieny SE et al. Infection with Schistosoma mansoni alters Th1/Th2 cytokine responses to a non-parasite antigen. J Immunol 1992; 148:3264 70.
20. Tang MLK, Kemp AS. Production and secretion of interferon-gamma (IFN-γ) in children with atopic dermatitis. Clin Exp Immunol 1994; 95:66 72.
21. Trinchieri G, Perussia B. Immune interferon: a pleiotropic lymphokine with multiple effects. Immunol Today 1985; 6:131 6.
22. Perussia B, Dayton ET, Fanning V, Thiagarajian P, Hoxie J, Trinchieri G. Immune interferon and leukocyte conditioned medium induce normal and leukemic myeloid cells to differentiate along the monocytic pathway. J Exp Med 1983; 158:2058 80.
23. Nathan CF, Muay HW, Wiebe ME, Rubin BY. Identification of interferon-γ as the lymphokine that activates human macrophage oxidative metabolism and antimicrobial activity. J Exp Med 1983; 158:670 89.