The systemic safety of fexofenadine HCl

Clinical and Experimental Allergy, Supplement

Volumn 29, Issue 3, 1999, Pages 163-170

  Mason, J ^a   Reynolds, R ^a   Rao, N ^b  

^a SANOFI   (France)

^b Hoescht Marion Roussel   (United States)

Author keywords

Fexofenadine; Psychomotor function; Seasonal allergic rhinitis; Sedation

Indexed keywords

ANTIHISTAMINIC AGENT; CETIRIZINE; ERYTHROMYCIN; FEXOFENADINE; HISTAMINE H1 RECEPTOR ANTAGONIST; KETOCONAZOLE; PLACEBO;

ALLERGIC RHINITIS; ANTICHOLINERGIC EFFECT; AREA UNDER THE CURVE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE CALCULATION; DRIVING ABILITY; DROWSINESS; DRUG SAFETY; DRUG TOLERABILITY; GASTROINTESTINAL SYMPTOM; HEADACHE; HUMAN; META ANALYSIS; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; PSYCHOMOTOR ACTIVITY; QUALITY OF LIFE; REVIEW; SEDATION; URINE RETENTION; URTICARIA;

EID: 0032815512     PISSN: 09602178     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2222.1999.0290s3163.x     Document Type: Review

References (19)

1. Pechadre JC, Beudin P, Eschalier A, Trolese JF, Rihoux JP. A comparision of central and peripheral effects of cetirizine and loratadine. J Int Med Res 1991; 19:289-95.
2. Riedel WJ, Van Veggel L, O'Hanlon JF. Cetirizine 10 and 20 mg impair psychomotor performance. Presented at the European Academy of Allergology and Immunology Annual Meeting, July 1990 Abstract P232.
3. Data on file. Hoechst Marion Roussel.
4. Bernstein DI, Schoenwetter WF, Nathan RA, Storms W, Ahlbrandt R, Mason J. Efficacy and safety of fexofenadine hydrochloride for treatment of seasonal allergic rhinitis. Ann Allergy Asthma Immunol 1997; 79:443-8.
5. Day J, Briscoe M, Welsh A, Smith J, Mason J. Onset of action, efficacy and safety of a single dose of 60 mg and 120 mg fexofenadine HCl for ragweed (RW) allergy using controlled antigen exposure in an environmental exposure unit (EEU). Ann Allergy Asthma Immunol 1997; 79:533-40.
6. Tinkelman D, Falliers C, Bronsky E, Kaiser H, Mason J, Ahlbrandt R. Efficacy and safety of fexofenadine HCl in fall seasonal allergic rhinitis. J Allergy Clin Immunol 1996; 97:435 (Abstract).
7. Stern MA, Bloom M. Fexofenadine HCl versus cetirizine as a once daily treatment of seasonal allergic rhinitis. Presented at the British Society of Allergology and Clinical Immunology Annual Meeting, September 1996 Abstract 0/05.
8. Paul E, Berth-Jones J, Ortonne J-P, Stern MA. Fexofenadine hydrochloride in the treatment of chronic idiopathic urticaria: a placebo-controlled, parallel-group, dose-ranging study. J Dermatol Treat 1998; 9:143-9.
9. Markham A, Wagstaff AJ. Fexofenadine. Drugs 1998; 55:269-74.
10. Russell T, Stoltz M, Eller M, Bhargava V, Weir S. Acute and subchronic dose tolerance of fexofenadine HCl in healthy male subjects. Ann Allergy Asthma Immunol 1996; 76:96 (Abstract).
11. Mathews KP. The urticarias. Current concepts in pathogenesis and treatment. Drugs 1985; 30:552-60.
12. Vermeeren A, O'Hanlon J. Fexofenadine's effects, alone and with alcohol, on actual driving and psychomotor performance. J Allergy Clin Immunol 1998; 101:306-11.
13. Lippert C, Ling J, Brown P, et al. Mass balance and pharmacokinetics of fexofenadine HCl in healthy male volunteers. Pharm Res 1995; 12:390.
14. Pratt C, Mason J, Russell T, Ahlbrandt R. Effect of fexofenadine HCl on corrected QT interval (QTc). Allergy 1997; 52 (Suppl. 37):67 (Abstract).
15. Lippert C, Rao N, Eller M, Weir S. Pharmacokinetics of fexofenadine in liver diseased patients. Pharm Res 1996; 13 (Suppl.):S431 (Abstract).
16. Robbins D, Horton M, Swan S, Hastenson C, Bhargava V, Weir S. Pharmacokinetics of fexofenadine in patients with varying degrees of renal impairment. Pharm Res 1996; 13 (Suppl.):S431 (Abstract).
17. Simons FER, Bergman JN, Watson WTA, Simons KJ. The clinical pharmacology of fexofenadine in children. J Allergy Clin Immunol 1996; 98:1062-4.
18. Rao N, Weilert D, Grave M, Eller M, Weir S. Pharmacokinetics of terfenadine acid metabolite, MDL 16,455 in healthy geriatric subjects. Pharm Res 1995; 12 (Suppl.);S386 (Abstract).
19. Tanner L, Reilly M, Meltzer E, Bradford J, Mason J. Evaluation of quality of life and health economic measures in patients treated with fexofenadine HCl for seasonal allergic rhinitis. Ann Allergy Asthma Immunol 1997; 78:125 (Abstract).