Onset of action, efficacy, and safety of a single dose of fexofenadine hydrochloride for ragweed allergy using an environmental exposure unit

Annals of Allergy, Asthma and Immunology

Volumn 79, Issue 6, 1997, Pages 533-540

  Day, James Halliday ^a   Briscoe, Maureen Phyllis ^a   Welsh, April ^a   Smith, Jeffrey Norman ^a   Clark, Adrian ^a   Ellis, Anne Kathleen ^a   Mason, Jolene ^b  

^a KINGSTON GENERAL HOSPITAL   (Canada)

^b Nordic Merrell Dow Research   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

FEXOFENADINE; TERFENADINE;

ADULT; ALLERGY; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; ENVIRONMENTAL EXPOSURE; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RAGWEED POLLEN; RANDOMIZED CONTROLLED TRIAL; SCORING SYSTEM;

EID: 0031449019     PISSN: 10811206     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1081-1206(10)63062-1     Document Type: Article

References (10)

1. Honig PK, Dale C, Woosley RL, et al. Changes in the pharmacokinetics and electrocardiographic pharmacodynamics of terfenadine with concomitant administration of erythromycin. Clin Pharmacol Ther 1992;52:231-8.
2. Honig PK, Wortham DC, Zamani K, et al. Terfenadine-ketoconazole interaction, pharmacokinetic and electrocardiographic consequences. JAMA 1993;269:1513-8.
3. Tinkelman D, Falliers C, Bronsky E, et al. Efficacy and safety of Fexofenadine HCL in fall seasonal allergic rhinitis [Abstract]. J Allergy Clin Immunol 1996;97:435.
4. Bernstein D, Schoenwetter W, Nathan R, et al. Fexofenadine: a new non-sedating antihistamine is effective in the treatment of seasonal allergic rhinitis [Abstract]. J Allergy Clin Immunol 1996;97:435.
5. Day JH, Clark RH, Gow D, Gibson M. Controlled pollen exposure - a new method of assessing drug efficacy [Abstract], N Engl Reg Allergy Proc 1988;9:298.
6. Day JH, Clark RH, Briscoe M, Dhillon M. Controlled pollen challenge is valuable in the assessment of anti-allergic medications [Abstract]. Clin Invest Med 1991;14(4):A5.
7. Donovan JP, Buckeridge DL, Briscoe MP, et al. Efficacy of immunotherapy to ragweed antigen tested by controlled antigen exposure. Ann Allergy Asthma Immunol 1996;77:74-80.
8. Day JH, Briscoe MP, Buckeridge D. et al. A randomized, double-blind, placebo-controlled antigen delivery study of the onset of action of aerosolized triamcinolone acetonide nasal spray in subjects with ragweed-induced allergic rhinitis. J Allergy Clin Immunol 1996; 97:1050-7.
9. Oei HD. Double-blind comparison of loratadine (SCH 29851), astemizole, and placebo in hay fever with special regard to onset of action. Ann Allergy 1988;61:436-9.
10. 1 antagonists antihistamines, terfenadine and astemizole, for hay fever. Thorax 1984;39:668-72.