Antitumor activity of benzo[a]phenothiazines

Anticancer Research

Volumn 19, Issue 3 A, 1999, Pages 1837-1842

  Motohashi, Noboru ^a   Kurihara, Teruo ^b   Satoh, Kazue ^c   Sakagami, Hiroshi ^d   Mucsi, Ilona ^e   Pusztai, Rozalia ^e   Szabó, Margit ^e   Molnár, Joseph ^e  

^a MEIJI PHARMACEUTICAL UNIVERSITY   (Japan)

^b JOSAI UNIVERSITY   (Japan)

^c SHOWA UNIVERSITY   (Japan)

^d MEIKAI UNIVERSITY SCHOOL OF DENTISTRY   (Japan)

^e UNIVERSITY OF SZEGED   (Hungary)

Author keywords

spin density; Apoptosis; Benzo a phenothiazines; Differentiation; Dipole moment; MDR; Radical; Tumor antigen

Indexed keywords

ASCORBIC ACID; FREE RADICAL; PHENOTHIAZINE DERIVATIVE; TUMOR ANTIGEN;

ANTINEOPLASTIC ACTIVITY; CELL DIFFERENTIATION; DRUG STRUCTURE; PRIORITY JOURNAL; REVIEW; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTIGENS, NEOPLASM; ANTINEOPLASTIC AGENTS; APOPTOSIS; ASCORBIC ACID; BIOLOGICAL TRANSPORT; CARCINOMA, EHRLICH TUMOR; CELL DIFFERENTIATION; CHEMISTRY, PHYSICAL; DRUG DESIGN; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; FREE RADICALS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MOLECULAR STRUCTURE; NEOPLASMS; NEOPLASMS, EXPERIMENTAL; P-GLYCOPROTEIN; PHENOTHIAZINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0032815114     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (20)

1. Motohashi N: Test for antitumor activities of phenothiazines and phenoxazines. (in Japanese) Yakugaku Zasshi 103: 364-371, 1983.
2. Tanaka M, Wayda K, Molnár J, Párkányi C, Aaron JJ and Motohashi N: Antimutagenicity of benzo[a]phenothiazines in chemically induced mutagenesis. Anticancer Res 17: 839-843, 1997.
3. Motohashi N, Sakagami H, Kamata K and Yamamoto Y: Cytotoxicity and differentiation-inducing activity of phenothiazine and benzo[a]phenothiazine derivatives. Anticancer Res 11: 1933-1938, 1991.
4. Satoh K, Sakagami H and Motohashi N: Radical modulation activity of benzo[a]phenothiazines. Anticancer Res 17: 2539-2544, 1997.
5. Motohashi N: Test for antitumor, antibacterial and antifungal activities of 9-substituted benzo[a]phenoxazine derivatives. (in Japanese) Yakugaku Zasshi 102: 992-994, 1982.
6. Sakagami H, Takahashi H, Yosida H, Yamamura M, Fukuchi K, Gomi K, Motohashi N and Takeda M: Induction of DNA fragmentation in human myelogenous leukemic cell lines by phenothiazine-related compounds. Anticancer Res 15: 2533-2540, 1995.
7. Satoh K, Sakagami H, Kurihara T and Motohashi N: Radical intensity and differentiation-inducing activity of benzo[a]-phenothiazine. Anticancer Res 17: 2465-2470, 1997.
8. Sakagami H, Satoh K, Ohata H, Takahashi H, Yoshida H, Iida M, Kuribayashi N, Sakagami T, Momose K and Takeda M: Relationship between ascorbyl radical intensity and apoptosis-inducing activity. Anticancer Res 16: 2635-2644, 1996.
9. Sakagami H, Satoh K, Hatano T, Yoshida T and Okuda T: Possible role of radical intensity and oxidation potential for gallic acid-induced apoptosis. Anticancer Res 17: 377-380, 1997.
10. Satoh K, Ao Y, Asano K and Sakagami H: Rapid determination of ascorbate by ESR spectroscopy. Anticancer Res 17: 3479-3484, 1997.
11. Kurihara T, Watanabe T, Yoshikawa K and Motohashi N: Radical productions and π-spin density by UHF/PM3 method on benz[c]acridines and benzo[a]phenothiazines. Anticancer Res 18: 429-432, 1998.
12. Satoh K, Sakagami H, Kadofuku T, Kurihara T and Motohashi N: Radical intensity and carcinogenic activity of benz[c]acridines. Anticancer Res 17: 3553-3557, 1997.
13. Motohashi N, Kurihara T, Yamanaka W, Satoh K, Sakagami H and Molnár J: Relationship between biological activity and dipole moment in benzo[a]phenothiazines. Anticancer Res 17: 3431-3436, 1997.
14. Molnár J, Pusztai R, Hevér A, Nagy S and Motohashi N: Effects of two benzo[a]phenothiazines on multi-drug resistance (mdr) and tumor antigen expression. Anticancer Res 15: 2013-2016, 1995.
15. Pusztai R, Motohashi N, Párkányi C, Aaron J-J, Kesava BR and Molnár J: Relationship between tumor (T) antigen expression and substituted effects on benzo[a]phenothiazines. Anticancer Res 16: 2961-2964, 1996.
16. Szabo M, Molnár J, Csiszár J and Motohashi N: Effect of chlorpromazine and benzo[a]phenothiazines on heterotrophic auxin requiring and autotrophic auxin non-requring tobacco tissue cultures. Anticancer Res 15: 2113-2116, 1995.
17. Párkányi C, Antonious MS, Aaron JJ, Maafi M, Gil O, Kersebet C and Motohashi N: Ground and excited singlet state dipole moments of new pharmacologically important phenothiazines. In: Barbe J, Keyzer H and Soyfer JC (eds), Biological and Chemical Aspects of Thiazines and Analogs. Enlight Associates, San Gabriel, CA, pp 177-187, 1995.
18. Aaron JJ, Maafi M, Kersebet C, Párkányi C, Antonious MS and Motohashi N: A solvatochromic study of new benzo[a]phenothiazines for the determination of dipole moments and specific solute-solvent interactions in the first excited singlet state. J Photochem Photobiol A: Chemistry 101: 127-136, 1996.
19. Mucsi I, Molnár J, Burián K, Béládi I, Sakagami H, Nakashima H, Inazawa K and Motohashi N: Antiviral activity of phenothiazine and benzo[a]phenothiazine derivatives. In: Barbe J, Keyzer H and Soyfer JC (eds.), Biological and Chemical Aspects of Thiazines and Analogs. Enlight Associates, San Gabriel, California. pp347-356, 1995.
20. McConnell HM and Dearman HH: Spin densities in the perinaphthenyl free radical. J Chem Phys 28: 51-53, 1958.