Higher activity of 8-oxo-2'-deoxyguanosine 5'-triphosphate pyrophosphohydrolase (8-oxo-dGTPase) coincides with lower background levels of 8-oxo-2'-deoxyguanosine in DNA of fetal compared with maternal mouse organs

Free Radical Biology and Medicine

Volumn 27, Issue 1-2, 1999, Pages 90-94

  Bialkowski, Karol ^a,b   Bialkowska, Aneta ^a,b   Anderson, Lucy M ^a   Kasprzak, Kazimierz S ^a  

^a SAIC FREDERICK INC   (United States)

^b NICOLAUS COPERNICUS UNIVERSITY   (Poland)

Author keywords

8 Oxo 2' deoxyguanosine; 8 oxo dGTPase; Free radicals; MTH1; Mutagenesis; MutT; Oxidative DNA damage

Indexed keywords

8 OXO 2 DEOXYGUANOSINE; 8 OXO 2'DEOXYGUANOSINE 5' TRIPHOSPHATE PYROPHOSPHOHYDROLASE; ANTIOXIDANT; BACTERIAL PROTEIN; DNA; PHOSPHATASE; UNCLASSIFIED DRUG;

ADOLESCENT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CARCINOGENESIS; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; ENZYME ACTIVITY; ESCHERICHIA COLI; FEMALE; FETUS; MALE; MOUSE; MUTAGENESIS; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL;

ANIMALS; DEOXYGUANOSINE; DNA; DNA REPAIR ENZYMES; FEMALE; FETUS; LIVER; LUNG; MALE; MICE; PHOSPHORIC MONOESTER HYDROLASES;

ANIMALIA; BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; MAMMALIA;

EID: 0032813292     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(99)00040-4     Document Type: Article

References (27)

1. Treffers H.P., Spinelli V., Belser N.O. A factor (or mutator gene) influencing mutation rates in Escherichia coli. Proc. Natl. Acad. Sci. USA. 40:1954;1064-1071.
2. Yanofsky C., Cox E.C., Horn V. The unusual mutagenic specificity of an E. coli mutator gene. Proc. Natl. Acad. Sci. USA. 55:1966;274-281.
3. Bhatnagar S.K., Bessman M.J. Studies on the mutator gene, mutT of Escherichia coli. Molecular cloning of the gene, purification of the gene product, and identification of a novel nucleoside triphosphatase. J. Biol. Chem. 263:1988;8953-8957.
4. Bhatnagar S.K., Bullions L.C., Bessman M.J. Characterization of the mutT nucleoside triphosphatase of Escherichia coli. J. Biol. Chem. 266:1991;9050-9054.
5. Maki H., Sekiguchi M. MutT protein specifically hydrolyses a potent mutagenic substrate for DNA synthesis. Nature. 355:1992;273-275.
6. Hayakawa H., Taketomi A., Sakumi K., Kuwano M., Sekiguchi M. Generation and elimination of 8-oxo-7,8-dihydro-2′-deoxyguanosine 5′-triphosphate, a mutagenic substrate for DNA synthesis, in human cells. Biochemistry. 34:1995;89-95.
7. Taddei F., Hayakawa H., Bouton M., Cirinesi A., Matic I., Sekiguchi M., Radman M. Counteraction by MutT protein of transcriptional errors caused by oxidative damage. Science. 278:1997;128-130.
8. Grollman A.P., Moriya M. Mutagenesis by 8-oxoguanine an enemy within . Trends Genet. 9:1993;246-249.
9. Sekiguchi M. MutT-related error avoidance mechanism for DNA synthesis. Genes Cells. 1:1996;139-145.
10. Pavlov Y.I., Minnick D.T., Izuta S., Kunkel T.A. DNA replication fidelity with 8-oxodeoxyguanosine triphosphate. Biochemistry. 33:1994;4695-4701.
11. Kamath-Loeb A.S., Hizi A., Kasai H., Loeb L.A. Incorporation of the guanosine triphosphate analogs 8-oxo-dGTP and 8- NH2-dGTP by reverse transcriptases and mammalian DNA polymerases. J. Biol. Chem. 272:1997;5892-5898.
12. Tajiri T., Maki H., Sekiguchi M. Functional cooperation of MutT, MutM and MutY proteins in preventing mutations caused by spontaneous oxidation of guanine nucleotide in Escherichia coli. Mutat. Res. 336:1995;257-267.
13. Cheng K.C., Cahill D.S., Kasai H., Nishimura S., Loeb L.A. 8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G - T and A - C substitutions. J. Biol. Chem. 267:1992;166-172.
14. Mo J.Y., Maki H., Sekiguchi M. Hydrolytic elimination of a mutagenic nucleotide, 8-oxo-dGTP, by human 18-kDa protein: sanitization of nucleotide pool. Proc. Natl. Acad. Sci. USA. 89:1992;11021-11025.
15. Bialkowski K., Kasprzak K.S. A novel assay of 8-oxo-2′-deoxyguanosine 5′-triphosphate pyrophosphohydrolase (8-oxo-dGTPase) activity in cultured cells and its use for evaluation of cadmium(II) inhibition of this activity. Nucleic Acids Res. 26:1998;3194-3201.
16. Furuichi M., Yoshida M.C., Oda H., Tajiri T., Nakabeppu Y., Tsuzuki T., Sekiguchi M. Genomic structure and chromosome location of the human mutT homologue gene MTH1 encoding 8-oxo-dGTPase for prevention of A:T to C:G transversion. Genomics. 24:1994;485-490.
17. Kakuma T., Nishida J., Tsuzuki T., Sekiguchi M. Mouse MTH1 protein with 8-oxo-7,8-dihydro-2′-deoxyguanosine 5′-triphosphatase activity that prevents transversion mutation. cDNA cloning and tissue distribution. J. Biol. Chem. 270:1995;25942-25948.
18. Cai J.P., Kakuma T., Tsuzuki T., Sekiguchi M. cDNA and genomic sequences for rat 8-oxo-dGTPase that prevents occurrence of spontaneous mutations due to oxidation of guanine nucleotides. Carcinogenesis. 16:1995;2343-2350.
19. Adachi S., Zeisig M., Moller L. Improvements in the analytical method for 8-hydroxydeoxyguanosine in nuclear DNA. Carcinogenesis. 16:1995;253-258.
20. Gornall A.G., Bardawill C.J., David M.M. Determination of serum proteins by means of the biuret reaction. J. Biol. Chem. 177:1949;751-766.
21. Sipowicz M.A., Amin S., Desai D., Kasprzak K.S., Anderson L.M. Oxidative DNA damage in tissues of pregnant mice and fetuses caused by the tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pirydyl)-1-butanone (NNK). Cancer Lett. 117:1997;87-91.
22. Fraga C.G., Shigenaga M.K., Park J.W., Degan P., Ames B.N. Oxidative damage to DNA during aging: 8-hydroxy-2′-deoxyguanosine in rat organ DNA and urine. Proc. Natl. Acad. Sci. USA. 87:1990;4533-4537.
23. Homma Y., Tsunoda M., Kasai H. Evidence for the accumulation of oxidative stress during cellular ageing of human diploid fibroblasts. Biochem. Biophys. Res. Commun. 203:1994;1063-1068.
24. Sakumi K., Furuichi M., Tsuzuki T., Kakuma T., Kawabata S., Maki H., Sekiguchi M. Cloning and expression of cDNA for a human enzyme that hydrolyzes 8-oxo-dGTP, a mutagenic substrate for DNA synthesis. J. Biol. Chem. 268:1993;23524-23530.
25. Kang D., Nishida J., Iyama A., Nakabeppu Y., Furuichi M., Fujiwara T., Sekiguchi M., Takeshige K. Intracellular localization of 8-oxo-dGTPase in human cells, with special reference to the role of the enzyme in mitochondria. J. Biol. Chem. 270:1995;14659-14665.
26. Kennedy C.H., Cueto R., Belinsky S.A., Lechner J.F., Pryor W.A. Overexpression of hMTH1 mRNA: a molecular marker of oxidative stress in lung cancer cells. FEBS Lett. 429:1998;17-20.
27. Randerath K., Zhou G.-D., Monk S.A., Randerath E. Enhanced levels in neonatal rat liver of 7,8-dihydro-8-oxo-2′-deoxyguanosine (8-hydroxydeoxyguanosine), a major mutagenic oxidative DNA lesion. Carcinogenesis. 18:1997;1419-1421.