The murine polycomb-group genes Ezh1 and Ezh2 map close to Hox gene clusters on mouse Chromosomes 11 and 6

Mammalian Genome

Volumn 10, Issue 3, 1999, Pages 311-314

  Laible, Götz ^a,d   Haynes, Andrew R ^b   Lebersorger, Angelika ^a   O'Carroll, Dónal ^a   Mattei, Marie Geneviève ^c   Denny, Paul ^b   Brown, Steve D M ^b   Jenuwein, Thomas ^a  

^a RESEARCH INSTITUTE OF MOLECULAR PATHOLOGY   (Austria)

^b Med Res Cncl Radiat Genome S   (United Kingdom)

^c INSERM   (France)

^d RUAKURA RESEARCH CENTRE   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

CHROMOSOME PROTEIN;

ANIMAL CELL; ARTICLE; CHROMOSOMAL LOCALIZATION; CHROMOSOME 11; CHROMOSOME 6; CONTROLLED STUDY; DNA PROBE; EMBRYO DEVELOPMENT; FLUORESCENCE IN SITU HYBRIDIZATION; GENE CLUSTER; GENE CONTROL; GENE MAPPING; GENETIC ANALYSIS; GROWTH REGULATION; HUMAN; HUMAN CELL; LEUKEMIA; MOUSE; NONHUMAN;

ANIMALS; BASE SEQUENCE; CHROMOSOME MAPPING; CROSSES, GENETIC; DNA PRIMERS; DNA-BINDING PROTEINS; DROSOPHILA PROTEINS; FEMALE; GENES, HOMEOBOX; MALE; MICE; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; NUCLEAR PROTEINS; PROTEINS; REPRESSOR PROTEINS; TRANSCRIPTION FACTORS;

EID: 0032811546     PISSN: 09388990     EISSN: None     Source Type: Journal    
DOI: 10.1007/s003359900993     Document Type: Article

References (25)

1. Abel K, Brody LC, Valdes JM, Erdos M, McKinley D, et al. (1996) Characterization of EZH1, a human homolog of Drosophila Enhancer of zeste near BRCA1. Genomics 37, 161-171
2. Breen M, Deakin L, Macdonald B, Miller S, Sibson R, et al. (1994) Towards high resolution maps of the mouse and human genomes - a facility for ordering markers to 0.1 cM resolution. Hum Mol Genet 3, 621-627
3. Chen H, Rossier C, Antonarakis SE (1996) Cloning of a human homolog of the Drosophila Enhancer of zeste gene (EZH2) that maps to chromosome 21q22.2. Genomics 38, 30-37
4. Cui X, De Vito I, Slany R, Miyamaoto A, Firestein R et al. (1998) Association of SET domain and myotubularin-related proteins modulates growth control. Nat Genet 18, 331-337
5. Djabali M, Selleri L, Parry P, Bower M, Young BD et al. (1992) A trithorax-Iike gene is interrupted by 11q23 translocations in acute leukemia. Nat Genet 2, 113-118
6. Gatti M, Baker BS (1989) Genes controlling essential cell-cycle functions in Drosophila melanogaster. Genes Dev 3, 438-453
7. Robert O, Sures I, Ciossek T, Fuchs M, Ullrich A (1996a) Isolation and developmental expression analysis of Enx-1, a novel mouse Polycomb gene. Mech Dev 55, 171-184
8. Hoben O, Jallal B, Ullrich A (1996b) Interaction of Vav with ENX-I, a putative transcriptional regulator of homeobox gene expression. Mol Cell Biol 16, 3066-3073
9. Husten E, Scherer G, Olowson M, Guénet J-L, Balling R (1996) Rbt (Rabo torcido), a new mouse skeletal mutation involved in anteroposterior patterning of the axial skeleton, maps close to the Ts (Tail-short) locus and distal to the Sox9 locus on chromosome 11. Mamm Genome 7, 881-885
10. Jenuwein T, Laible G, Dorn R, Reuter G (1998) SET-domain proteins modulate chromatin domains in eu-and heterochromatin. Cell Mol Life Sci 54, 80-93
11. Jones RS, Gelbart WM (1993) The Drosophila Polycomb-group gene Enhancer of zeste contains a region with sequence similarity to trithorax. Mol Cell Biol 13, 6357-6366
12. Jürgens G (1985) A group of genes controlling the spatial expression of the bithorax complex in Drosophila. Nature 316, 153-155
13. Korf I, Fan Y, Strome S (1998) The Polycomb group in Caenorhabditis elegans and maternal control of germline development. Development 125, 2469-2478
14. Laible G, Wolf A, Dorn R, Reuter G, Nislow C et al. (1997) Mammalian homologues of the Polycomb-group gene Enhancer of zeste mediate gene silencing in Drosophila heterochromatin and at S. cereviseae telomeres. EMBO J 16, 3219-3232
15. Liu XC, Newton VE, Steel KP, Brown SD (1997) Identification of a new mutation of the myosin VII head region in Usher syndrome type 1. Hum Mutat 10, 168-170
16. Montgomery JC, Silverman KA, Buchberg AM (1998) Mouse Chromosome 11. Mamm Genome 8(Suppl), S215-S240
17. Paro R, Harte PJ (1996) The role of Polycomb group and trithorax group complexes in the maintenance of determined cell states. In Epigenetic Mechanisms of Gene Regulation, VEA Russo, RA Martienssen, AD Riggs, eds. (New York, N.Y.: CSHL Press), pp 507-528
18. Phillips MD, Shearn A (1990) Mutations in polycombeotic, a Drosophila Polycomb-group gene, cause a wide range of maternal and zygotic phenotypes. Genetics 125, 91-101
19. Pinkel D, Straume T, Gray JW (1986) Cytogenetic analysis using quantitative, high sensitivity, fluorescence hybridization. Proc Natl Acad Sci USA 83, 2934-2938
20. Pirrotta V (1997) PcG complexes and chromatin silencing. Curr Opin Genet Dev 7, 249-258
21. Rastelli L, Chan CS, Pirrotta V (1993) Related chromosome binding sites for zeste, suppressors of zeste and Polycomb group proteins in Drosophila and their dependence on Enhancer of zeste function. EMBO J 12, 1513-1522
22. Rhodes M, Straw R, Fernando S, Evans A, Lacey T et al. (1998) A high resolution microsatellite map of the mouse genome. Genome Res 8, 531-542
23. Tkachuk DC, Kohler S, Cleary ML (1992) Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias. Cell 71, 691-700
24. Tschiersch B, Hofmann A, Krauss V, Dorn R, Korge G et al. (1994) The protein encoded by the Drosophila position-effect variegation suppressor gene Su(var)3-9 combines domains of antagonistic regulators of homeotic gene complexes. EMBO J 13, 3822-3831
25. van Lohuizen M (1998) Functional analysis of mouse Polycomb group genes. Cell Mol Life Sci 54, 71-79