Gelatin behaviour in dilute aqueous solution: Designing a nanoparticulate formulation

Journal of Pharmacy and Pharmacology

Volumn 51, Issue 6, 1999, Pages 643-649

  Farrugia, Claude A ^a   Groves, Michael J ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; GELATIN; NANOPARTICLE;

AQUEOUS SOLUTION; ARTICLE; COVALENT BOND; DENATURATION; DRUG FORMULATION; GEL PERMEATION CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOELECTRIC POINT; LIGHT SCATTERING; MOLECULAR WEIGHT; PH; PRECIPITATION; RENATURATION; TEMPERATURE; TIME;

CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG DELIVERY SYSTEMS; GELATIN; HYDROGEN-ION CONCENTRATION; MOLECULAR WEIGHT; SOLUBILITY; SOLUTIONS;

EID: 0032808341     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/0022357991772925     Document Type: Article

References (20)

1. Cantor, C. R., Schimmel, P. R. (1980) The kinetics of ligand interactions. In: Cantor, C. R., Schimmel, P. R. (eds) Biophysical Chemistry, Part III, The Behavior of Biological Macromolecules, Freeman and Company, San Francisco, pp 887-938
2. Courts, A. (1954) The N-terminal amino acid residues of gelatin 2. Thermal degradation. Biochem. J. 58: 74-79
3. El-Samaligy, M., Rohdewald, P. (1982) Triamcinolone diacetate nanoparticles, a sustained-release drug-delivery system suitable for parenteral administration. Pharm. Acta Helv. 57: 201-204
4. El-Samaligy, M., Rohdewald, P. (1983) Reconstituted collagen nanoparticles. A novel drug-delivery system. J. Pharm. Pharmacol. 35: 537-539
5. Elysée-Collen, B., Lencki, R. W. (1996) Protein ternary phase diagrams. I. Effect of ethanol, ammonium sulfate, and temperature on the phase behavior of type B gelatin. J. Agric. Food Chem. 44: 1651-1657
6. Flory, P. J., Weaver, E. S. (1960) Helix ↔ Coil transitions in dilute aqueous collagen solutions. J. Am. Chem. Soc. 82: 4518-4525
7. Johns, P., Courts, A. (1977) Relationship between collagen and gelatin. In: Ward, A. G., Courts, A. (eds) The Science and Technology of Gelatin, Academic Press, New York, pp 138-178
8. Jones, R. T. (1987) Gelatin: physical and chemical properties. In: Ridgway, K. (ed.) Hard Capsules: Development and Technology, The Pharmaceutical Press, London, pp 31-48
9. Kreuter, J. (1994) Nanoparticles. In: Kreuter, J. (ed.) Colloidal Drug-Delivery Systems, Marcel Dekker, New York, pp 219-342
10. Lorry, D., Vedrines, M. (1985) Determination of molecular-weight-distribution of gelatines by H.P.S.E.C. In: Ammann-Brass, H., Pouradier, J. (eds) Photographic Gelatin. Proc. Fourth IAG Conf., Fribourg, 1983, International Working Group for Photographic Gelatin, Fribourg, pp 35-54
11. Marty, J. J., Oppenheim, R. C., Speiser, P. (1978) Nanoparticles - a new colloidal drug-delivery system. Pharm. Acta Helv. 53: 17-23
12. Oppenheim, R. C. (1986) Nanoparticulate drug delivery systems based on gelatin and albumin. In: Guiot, P., Couvreur, P. (eds) Polymeric Nanoparticles and Microspheres, CRC Press, Florida, pp 1-26
13. Perrin, D. D., Dempsey, B. (1974) Composition-pH tables of some commonly used buffers. In: Perrin, D. D., Dempsey, B. (eds) Buffers for pH and Metal-Ion Control, Chapman and Hall, London, pp 128-156
14. Piez, K. A., Weiss, E., Lewis, M. S. (1960) The separation and characterization of the α-and β-components of calf-skin collagen. J. Biol. Chem. 235: 1987-1991
15. Piez, K. A., Lewis, M. S., Martin, G. R., Gross, J. (1961) Subunits of the collagen molecule. Biochim. Biophys. Acta 53: 596-598
16. Privalov, P. L., Gill, S. J. (1988) Stability of protein structure and hydrophobic interactions. Adv. Protein Chem. 39: 191-234
17. Steckert, J., Kramer, D., Brand, J. (1992) Preparative chromatography and analysis of molecular-weight fractions of gelatin. J. Photogr. Sci. 40: 134-137
18. Steven, F. S., Tristram, G. R. (1962) The denaturation of acetic acid-soluble calf-skin collagen. Biochem. J. 85: 207-210
19. Veis, A., Anesey, J., Cohen, J. (1962) The characterization of the θ-component of gelatin. Arch. Biochem. Biophys. 98: 104-110
20. Von Hippel, P. H., Harrington, W. F. (1959) Enzymic studies of the gelatin collagen-fold transition. Biochim. Biophys. Acta 36: 427-447