Effect of inhalation exposure to 2-bromopropane on the nervous system in rats

Toxicology

Volumn 135, Issue 2-3, 1999, Pages 87-93

  Yu, Xiaozhong ^a   Ichihara, Gaku ^a   Kitoh, Junzoh ^a   Xie, Zhenlin ^a   Shibata, Eiji ^b   Kamijima, Michihiro ^a   Asaeda, Nobuyuki ^c   Hisanaga, Naomi ^d   Takeuchi, Yasuhiro ^a  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c SANWA KAGAKU KENKYUSHO CO LTD   (Japan)

^d NATL INSTITUTE OF INDUSTRIAL HEALTH   (Japan)

Author keywords

2 Bromopropane; Distal latency; Electrophysiology; Histopathology; Inhalation exposure; Motor nerve conduction velocity; Peripheral neurotoxicity

Indexed keywords

2 BROMOPROPANE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; BRAIN WEIGHT; CHRONIC TOXICITY; CONTROLLED STUDY; ELECTROPHYSIOLOGY; HISTOPATHOLOGY; INHALATION; MALE; MOTOR NERVE CONDUCTION; MYELIN SHEATH; NEUROTOXICITY; NONHUMAN; PERIPHERAL NEUROPATHY; PERONEUS NERVE; PRIORITY JOURNAL; RAT;

ADMINISTRATION, INHALATION; ANIMALS; BODY WEIGHT; BRAIN; DOSE-RESPONSE RELATIONSHIP, DRUG; HYDROCARBONS, BROMINATED; KIDNEY; LIVER; MALE; MOTOR NEURONS; MUTAGENS; MYELIN SHEATH; NERVOUS SYSTEM; NEURAL CONDUCTION; ORGAN SIZE; PERONEAL NERVE; RATS; RATS, WISTAR; REACTION TIME; TIME FACTORS;

EID: 0032806891     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(99)00053-0     Document Type: Article

References (19)

1. Dalton A.J. A chrome-osmium fixative for electron microscope. Anat. Rec. 121:1955;281-284.
2. Fullerton P.M., Barnes J.M. Peripheral neuropathy in rats produced by acrylamide. Br. J. Ind. Med. 23:1966;210-221.
3. Herr D.W., Vo K.T., Morgan D.L., Sills R.C. Carbon distilfide neurotoxicity in rats: VI. Electrophysiological examination of caudal tail nerve compound action potentials and nerve conduction velocity. Neurotoxicology. 19:1998;129-146.
4. Ichihara G., Asaeda N., Kumazawa T., Takawa Y., Kamijima M., Yu X., Kondo H., Nakajima T., Kitoh J., Yu J., Moon Y., Hisanaga N., Takeuchi Y. Testicular and hematopoietic toxicity of 2-bromo-propane, a substitute for ozone layer-depleting chlorofluorocarbons. J. Occup. Health. 39:1997;57-63.
5. Kamijima M., Ichihara G., Kitoh J., Tsukamura H., Maeda K., Yu X., Xie Z., Nakajima T., Asaeda N., Hisanaga N., Takeuchi Y. Ovarian toxicity of 2-bromopropane in the non-pregnant female rat. J. Occup. Health. 39:1997;144-149.
6. Kim Y., Jung K., Hwang T., Jung G., Kim H., Park J., Kim J., Park J., Park D., Park S., Choi K., Moon Y. Hematopoietic and reproductive hazards of Korean electronic workers exposed to solvents containing 2-bromopropane. Scand. J. Work Environ. Health. 22:1996;387-391.
7. Kluver H., Barrera E. A method for the combined staining of cells and fibers in the nervous system. J. Neuropathol. Exp. Neurol. 12:1953;4-7.
8. Moser V.C., McCormick J.P., Creason J.P., Macphail R.C. Comparison of chlordimeform and carbaryl using a functional observational battery. Fund. Appl. Toxicol. 11:1988;189-206.
9. Nakajima T., Shimodaira S., Ichihara G., Asaeda N., Kumazawa T., Iwai H., Ichikawa I., Kamijima M., Yu X., Xie Z., Kondon H., Takeuchi Y. 2-Bromopropane-induced hypoplasia of bone marrow in male rats. J. Occup. Health. 39:1997;228-233.
10. Nylen P., Hagman M., Johnson A. Function of auditory and visual systems, and of peripheral nerve, in rats after long-term combined exposure to n-hexane and methylated benzene derivatives I. Toluene. Pharmacol. Toxicol. 74:1994;116-123.
11. Nylen P., Hagman M. Function of auditory and visual systems, and of peripheral nerve, in rats after long-term combined exposure to n-hexane and methylated benzene derivatives II. Xylene. Pharmacol. Toxicol. 74:1994;124-129.
12. Ono Y., Takeuchi Y., Hisanaga N. A comparative study on the toxicity of n-hexane and its isomers on the peripheral nerve. Int. Arch. Occup. Environ. Health. 48:1981;289-294.
13. Park J., Kim Y., Park D., Choi K., Park S., Moon Y. An outbreak of hematopoietic and reproductive disorders due to solvents containing 2-bromopropane in an electronic factory, South Korea: epidemiological survey. J. Occup. Health. 39:1997;138-143.
14. Safety Center, 1996. Intoxicant accident of solvents in an electronic factory, South Korea: witness from an affected worker (in Japanese). Anzen Jonhou Senta 12, 15-16.
15. Takeuchi Y., Koike Y. Electrophysiological methods for the in vivo assessment of neurotoxicity. Blum K., Manzo L. Neurotoxicology. 1985;613-629 Marcel Dekker, New York.
16. Takeuchi Y., Huang J., Shibata E., Hisanaga N., Ono Y. A trial to automate an organic solvent exposure system for small animals. Jpn. J. Ind. Health. 31:1989;722. In Japanese.
17. Takeuchi Y., Ono Y., Hisanaga N. An experimental study on the combined effects of n-hexane and toluene on the peripheral nerve of the rat. Br. J. Ind. Med. 38:1981;1419.
18. Takeuchi Y., Ono Y., Hisanaga N., Kitoh J., Sugiura Y. A comparative study on the neurotoxicity of n-pentane., n-hexane, and n-heptane in the rat. Br. J. Ind. Med. 37:1980;241-247.
19. Yamamoto T., Teramoto K., Horiguchi S. Effect of styrene on peripheral nerve conduction velocities in rats. J. Occup. Health. 39:1997;319-324.