Immunoassay detection of hepatitis B surface antigen mutants

Journal of Medical Virology

Volumn 59, Issue 1, 1999, Pages 19-24

  Coleman, Paul F ^a   Chen, Y C Jack ^a   Mushahwar, Isa K ^a,b  

^a ABBOTT DIAGNOSTICS   (United States)

^b ABBOTT LABORATORIES   (United States)

Author keywords

HBsAg; Monoclonal antibody epitope; Vaccine escape mutants; Variants

Indexed keywords

HEPATITIS B ANTIGEN;

ACTIVE IMMUNIZATION; ANTIGEN DETECTION; ARTICLE; DIAGNOSTIC VALUE; FOLLOW UP; HEPATITIS B; HUMAN; IMMUNOASSAY; POLYMERASE CHAIN REACTION; TREATMENT OUTCOME; VIRUS INFECTIVITY; VIRUS MUTATION; VIRUS RESISTANCE;

HEPATITIS B; HEPATITIS B SURFACE ANTIGENS; HEPATITIS B VACCINES; HEPATITIS B VIRUS; HUMANS; IMMUNOASSAY; MUTATION; REAGENT KITS, DIAGNOSTIC; RECOMBINANT PROTEINS; VACCINATION;

EID: 0032804970     PISSN: 01466615     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-9071(199909)59:1<19::AID-JMV4>3.0.CO;2-B     Document Type: Article

References (22)

1. Brown SE, Howard Cr, Zuckerman AJ, Steward MW. 1984. Affinity of antibody responses in man to hepatitis B vaccine determined with synthetic peptides. Lancet 2:184-187.
2. Carman, WF, Zanetti AR, Karayiannis P, Waters J, Tanzi E, Zuckerman AJ, Thomas HC. 1990. Vaccine-induced escape mutant of hepatitis B virus. Lancet 336:325-329.
3. Carman WF, Korula J, Wallace L, MacPhee R, Mimms L, Decker R. 1995. Fulminant reactivation of hepatitis B due to envelope protein mutant of HBV that escaped detection by monoclonal HBsAg ELISA. Lancet 345:1406-1407.
4. Carman WF, VanDeursen FJ, Mimms LT, Hardie D, Coppola R, Decker R, Sanders R. 1997. The prevalence of surface antigen variants of hepatitis B virus in Papua New Guinea, South Africa and Sardinia. Hepatology 26:1658-1666.
5. Grethe S, Monazahian M, Bohme I, Thomssen R. 1998. Characterization of unusual escape variants of hepatitis B virus isolated from a hepatitis B surface antigen-negative subject. J Virol 72:7692-7696.
6. Gunther S, Sommer G, von Breunig F, Iwanska A, Kalinina T, Sterneck M, Will H. 1998. Amplification of full-length hepatitis B virus genomes from samples from patients with low levels of viremia: frequency and functional consequences of PCR-introduced mutations. J Clin Microbiol 36:531-538.
7. Hou JL, Karayiannis P, Thomas HC, Lou KX. 1995. A unique insertion in the S gene of surface antigen negative HBV in Chinese carriers. Hepatology 21:273-278.
8. Jongerius J, Wester M, Cuypers H, van Oostendorp W, Lelie P, van der Poel C, van Leeuwen E. 1998. New hepatitis B virus mutant form in a blood donor that is undetectable in several hepatitis B surface antigen screening assays. Transfusion 38:56-59.
9. Karthigesu VD, Allison LMC, Fortain M, Mendy M, Whittle HC, Howard CR. 1994. A novel hepatitis B virus variant in the sera of immunised children. J Gen Virol 75:443-448.
10. McMahon G, Ehrlich PH, Moustafa ZA, McCarthy LA, Dottavio D, Tolpin MD, Nadler PI, Ostberg L. 1992. Genetic alterations in the gene encoding the major HBsAg: DNA and immunological analysis of recurrent HBsAg derived from monoclonal antibody-treated liver transplant patients. Hepatology 15:757-766.
11. Moriyama K, Nakajma E, Hohjoh H, Asayama R, Okochi K. 1991. Immunoselected hepatitis B virus mutant. [Letter.] Lancet 337: 125.
12. Mushahwar IK, Brawner T. 1992. Radioimmunoassays. In: Spector S, Lancz G, editors. Clinical virology manual. 2nd Ed. New York: Elsevier. p 129-151.
13. Okamoto H, Yano K, Nozaki Y, Matsui A, Miyazaki H, Yamamoto K, Tsuda F, Machida A, Mishiro S. 1992. Mutations within the S gene of hepatitis B virus transmitted from mothers to babies immunized with hepatitis B immune globulin and vaccine. Pediatr Res 32:264-269.
14. Oon CJ, Lim G-K, Ye Z, Goh K-T, Tan K-L, Yo S-L, Hopes E, Harrison TJ, Zuckerman AJ. 1995. Molecular epidemiology of hepatitis B virus vaccine variants in Singapore. Vaccine 13:699-702.
15. Sambrook J, Fritsch EF, Maniatis T, editors. 1989. Molecular cloning: a laboratory manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press. E3 p.
16. Tang J, Yeh C, Chen T, Hsieh S, Chu C, Liaw Y. 1998. Emergence of an S gene mutant during thymosin alpha therapy in a patient with chronic hepatitis B. J Infect Dis 178:866-869.
17. Wallace LA, Echevarria JE, Echevarria JM, Carman WF. 1994. Molecular characterization of envelope antigenic variants of hepatitis B virus from Spain. J Infect Dis 170:1300-1303.
18. Yamamoto K, Horikita M, Tsuda F, Itoh K, Akahane Y, Yotsumoto S, Okamoto H, Miyakawa Y, Mayumi M. 1994. Naturally occurring escape mutants of hepatitis B virus with various mutations in the S gene in carriers seropositive for antibody to hepatitis B antigen. J Virol 68:2671-2676.
19. Zanetti AR, Tanzi E, Manzillo G, Maio G, Sbreglia C, Caporaso N, Thomas H, Zuckerman AJ. 1988. Hepatitis B variant in Europe. Lancet 2:1132-1133.
20. Zuckerman AJ. 1990. Immunization against hepatitis B. Br Med Bull 46:383-398.
21. Zuckerman AJ. 1996. Developing new hepatitis B immunization strategies. Gut 38:560-562.
22. Zuckerman AJ, Harrison TJ, Oon C. 1994. Mutants in the S region of hepatitis B virus. Lancet 343:737-738.