Autografting of highly purified peripheral blood progenitor cells following myeloablative therapy in patients with lymphoma: A prospective study of the long-term effects on tumor eradication, reconstitution of hematopoiesis and immune recovery

Bone Marrow Transplantation

Volumn 24, Issue 2, 1999, Pages 153-161

  Dreger, P ^b   Viehmann, K ^c   Von Neuhoff, N ^c   Glaubitz, T ^c   Petzoldt, O ^c   Glass, B ^c   Uharek, L ^c   Rautenberg, P ^c   Suttorp, M ^c   Mills, B ^a   Mitsky, P ^a   Schmitz, N ^c  

^a Nexell Therapeutics Inc   (United States)

^b Second Department of Medicine   (Germany)

^c NONE

Author keywords

CD34+ selection; Immune recovery; Immunomagnetic; Lymphoma; PBPC

Indexed keywords

ANTINEOPLASTIC AGENT; CARMUSTINE; CD34 ANTIGEN; CD4 ANTIGEN; CD45 ANTIGEN; CHLORAMBUCIL; CYCLOPHOSPHAMIDE; CYTARABINE; DEXAMETHASONE; DOXORUBICIN; ETOPOSIDE; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; MEASLES ANTIBODY; MELPHALAN; PREDNISOLONE; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR; VINCRISTINE;

ADULT; ARTICLE; AUTOGRAFT; BONE MARROW PURGING; CELL SELECTION; CHROMOSOME TRANSLOCATION 14; CHRONIC LYMPHATIC LEUKEMIA; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE COURSE; FEMALE; FOLLICULAR LYMPHOMA; FOLLOW UP; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; HUMAN CELL; IMMUNOCOMPETENCE; IMMUNOCYTOMA; IMMUNOGLOBULIN BLOOD LEVEL; LYMPHOCYTE SUBPOPULATION; MALE; MANTLE CELL LYMPHOMA; MONOCLONAL IMMUNOGLOBULINEMIA; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; RECURRENT DISEASE; T LYMPHOCYTE; THROMBOCYTE COUNT;

EID: 0032803918     PISSN: 02683369     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bmt.1701862     Document Type: Article

References (34)

1. Gribben JG, Freedman AS, Neuberg D et al. Immunologic purging of marrow assessed by PCR before autologous bone marrow transplantation for B cell lymphoma. New Engl J Med 1991; 325: 1525-1533.
2. Rohatiner AZS, Johnson PWM, Price CGA et al. Myeloablative therapy with autologous bone marrow transplantation as consolidation therapy for recurrent follicular lymphoma. J Clin Oncol 1994; 12: 1177-1184.
3. Haas R, Brittinger G, Meusers P et al. Myeloablative therapy with blood stem cell transplantation is effective in mantle cell lymphoma. Leukemia 1996; 10: 1975-1979.
4. Dreger P, von Neuhoff N, Kuse R et al. Early stem cell transplantation for chronic lymphocytic leukaemia: a chance for cure? Br J Cancer 1998; 77: 2291-2297.
5. Hardingham JE, Kotasek D, Sage RE et al. Molecular detection of residual lymphoma cells in peripheral blood stem cell harvests and following autologous transplantation. Bone Marrow Transplant 1993; 11: 15-20.
6. Brenner MK, Rill DR. Gene marking to improve the outcome of autologous bone marrow transplantation. J Hematother 1994; 3: 33-36.
7. + peripheral-blood stem-cell transplants for follicular lymphoma: a pilot study. J Clin Oncol 1997; 15: 2288-2295.
8. Lopez M, Lemoine FM, Firat H et al. Bone marrow vs peripheral blood progenitor cells CD34 selection in patients with non-Hodgkin's lymphomas: different levels of tumor cell reduction. Implications for autografting. Blood 1997; 90: 2830-2838.
9. Mapara MY, Körner IJ, Hildebrandt M et al. Monitoring of tumor cell purging after highly efficient immunomagnetic selection of CD34 cells from leukapheresis products in breast cancer patients: comparison of immunocytochemical tumor cell staining and reverse transcriptase-polymerase chain reaction. Blood 1997; 89: 337-344.
10. + peripheral blood stem cells for autografting in patients with breast cancer. Br J Haematol 1997; 97: 881-888.
11. + cells from blood stem cell components using the Baxter Isolex system. Bone Marrow Transplant 1998; 21: 1253-1262.
12. Harris NL, Jaffe ES, Stein H et al. A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group. Blood 1994; 84: 1361-1392.
13. Hiddemann W, Longo DL, Coiffier B et al. Lymphoma classification - the gap between biology and clinical management is closing. Blood 1996; 88: 4085-4089.
14. Pfreundschuh M, Rueffer U, Lathan B et al. DEXA-BEAM in patients with Hodgkin's disease refractory to multi-drug regimens: a multicenter trial of the German Hodgkin's Study Group. J Clin Oncol 1994; 12: 580-586.
15. Dreger P, Marquardt P, Haferlach T et al. Effective mobilisation of peripheral blood progenitor cells with 'Dexa-BEAM' and G-CSF: timing of harvesting and composition of the leukapheresis product. Br J Cancer 1993; 68: 950-957.
16. Schmitz N, Linch DC, Dreger P et al. Randomised trial of filgrastim-mobilised peripheral blood progenitor cell transplantation vs autologous bone-marrow transplantation in lymphoma patients. Lancet 1996; 347: 353-357.
17. von Neuhoff N, Dreger P, Suttorp M et al. Comparison of different strategies of molecular genetic monitoring following autologous stem cell transplantation in patients with follicular lymphoma. Bone Marrow Transplant 1998; 22: 161-166.
18. Shpall EJ, LeMaistre CF, Holland K et al. A prospective randomized trial of buffy coat versus CD34-selected autologous bone marrow support in high-risk breast cancer patients receiving high-dose chemotherapy. Blood 1997; 90: 4313-4320.
19. Paulus U, Schmitz N, Viehmann K et al. Combined positive/negative selection for highly effective purging of PBPC grafts: towards clinical application in patients with B-CLL. Bone Marrow Transplant 1997; 20: 415-420.
20. Navarro J, Touraine J-L. Promotion of fetal liver engraftment by T cells in a murine semiallogeneic model without graft-versus-host reaction. Transplantation 1989; 47: 871-876.
21. Bensinger WI, Rowley S, Lilleby K et al. Reduction in graft-versus-host disease (GVHD) after transplantation of CD34 selected, allogeneic peripheral blood stem cells in older patients with advanced hematologic malignancies. Blood 1996; 88 (Suppl. 1): 421a (Abstr.).
22. Henon P, Debecker A, Lepers M et al. Hemopoietic and immune reconstitution following peripheral blood stem cell autografting in acute leukemia. Bone Marrow Transplant 1988; 3: 171-172.
23. Roberts MM, To LB, Gillis D et al. Immune reconstitution following peripheral blood stem cell transplantation, autologous bone marrow transplantation and allogeneic bone marrow transplantation. Bone Marrow Transplant 1993; 12: 469-475.
24. Ashihara E, Shimazaki C, Yamagata N et al. Reconstitution of lymphocyte subsets after peripheral blood stem cell transplantation: two-color flow cytometric analysis. Bone Marrow Transplant 1994; 13: 377-381.
25. Talmadge JE, Reed E, Ino K et al. Rapid immunologic reconstitution following transplantation with mobilized peripheral blood stem cells as compared to bone marrow. Bone Marrow Transplant 1997; 19: 161-172.
26. Lowdell MW, Craston R, Ray N et al. The effect of T cell depletion with campath-1M on immune reconstitution after chemotherapy and allogeneic bone marrow transplant as treatment for leukemia. Bone Marrow Transplant 1998; 21: 679-686.
27. Hakim FT, Cepeda R, Kaimei S et al. Constraints on CD4 recovery post-chemotherapy in adults: thymic insufficiency and apoptotic decline of expanded peripheral CD4 cells. Blood 1997; 90: 3789-3798.
28. Roux E, Helg C, Dumont GF et al. Analysis of T-cell repopulation after allogeneic bone marrow transplantation: significant differences between recipients of T-cell depleted and unmanipulated grafts. Blood 1996; 87: 3984-3992.
29. + hematopoietic progenitors. Blood 1998; 91: 2588-2600.
30. Fischer AM, Simon F, Le Deist F et al. Prospective study of the occurrence of monoclonal gammopathies following bone marrow transplantation in young children. Transplantation 1990; 49: 731-735.
31. Zent CS, Wilson CS, Tricot G et al. Oligoclonal protein bands and Ig isotype switching in multiple myeloma treated with high-dose therapy and hematopoietic cell transplantation. Blood 1998; 91: 3518-3523.
32. Pauksen K, Duraj V, Ljungman P et al. Immunity to and immunization against measles, rubella and mumps in patients after autologous bone marrow transplantation. Bone Marrow Transplant 1992; 9: 427-432.
33. Tyndall A, Gratwohl A. Bone marrow transplantation in the treatment of autoimmune diseases. Br J Rheumatol 1997; 36: 1-5.
34. Sivakumaran M, Hutchinson RM, Pringle H et al. Thrombocytopenia following autologous bone marrow transplantation: evidence for autoimmune aetiology and B cell clonal involvement. Bone Marrow Transplant 1995; 15: 531-536.