Effects of CP-060S, a novel Ca2+ channel blocker, on oxidative stress in cultured cardiac myocytes

European Journal of Pharmacology

Volumn 385, Issue 1, 1999, Pages 81-88

  Hara, Akiyoshi ^a   Suzuki, Takahiko ^b   Hashizume, Hiroko ^a   Shishido, Naomi ^a   Nakamura, Masao ^a   Ushikubi, Fumitaka ^a   Abiko, Yasushi ^a  

^a ASAHIKAWA MEDICAL COLLEGE   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

Anti oxidant; Ca2+ channel blocker; Cardiac myocyte; Diltiazem; Hydrogen peroxide

Indexed keywords

2 (3,5 DI TERT BUTYL 4 HYDROXYPHENYL) 3 [3 [N METHYL N [2 (3,4 METHYLENEDIOXYPHENOXY)ETHYL]AMINO]PROPYL] 4 THIAZOLIDINONE; 3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; CALCIUM CHANNEL BLOCKING AGENT; DILTIAZEM; DIMETHYLTHIOUREA; HYDROGEN PEROXIDE; LACTATE DEHYDROGENASE;

ANIMAL CELL; ARTICLE; CELL CULTURE; CONTROLLED STUDY; CULTURE MEDIUM; ENANTIOMER; HEART MUSCLE CELL; IN VITRO STUDY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; SPIN TRAPPING;

ANIMALS; ANIMALS, NEWBORN; CALCIUM CHANNEL BLOCKERS; CELL SURVIVAL; CELLS, CULTURED; CYCLIC N-OXIDES; DILTIAZEM; FREE RADICAL SCAVENGERS; HYDROGEN PEROXIDE; HYDROXYL RADICAL; L-LACTATE DEHYDROGENASE; MYOCARDIUM; OXIDANTS; OXIDATIVE STRESS; PHENOLS; RATS; RATS, SPRAGUE-DAWLEY; STEREOISOMERISM; THIAZOLES; THIAZOLIDINES; THIOUREA;

EID: 0032801825     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(99)00708-6     Document Type: Article

References (30)

1. Bergmeyer H.U. Methods of Enzymatic Analysis. 1974;574-579 Academic Press, New York.
2. Brown J.M., Terada L.S., Grosso M.A., Whitmann G.J., Velasco S.E., Patt A., Harken A.H., Repine J.E. Xanthine oxidase produces hydrogen peroxide, which contributes to reperfusion injury of ischemic, isolated, perfused rat hearts. J. Clin. Invest. 81:1988;1297-1301.
3. Byler R.M., Sherman N.A., Wallner J.S., Horwitz L.D. Hydrogen peroxide cytotoxicity in cultured cardiac myocytes is iron dependent. Am. J. Physiol. 266:1994;H121-H127.
4. Clague J.R., Langer G.A. The pathogenesis of free radical-induced calcium leak in cultured rat cardiomyocytes. J. Mol. Cell. Cardiol. 26:1994;11-21.
5. Finkelstein E., Rosen G.M., Rauckman E.J. Spin trapping of superoxide and hydroxyl radical: practical aspects. Arch. Biochem. Biophys. 200:1980;1-16.
6. Fisher A.B. Intracellular production of oxygen-derived free radicals. Halliwell B. Oxygen Radicals and Tissue Injury. 1988;34-39 The Upjohn Company, Bethesda.
7. 2+ exchange in ventricular myocytes. Am. J. Physiol. 271:1996;H823-H833.
8. Gotoh N., Shimizu K., Komuro E., Tsuchiya J., Noguchi N., Niki E. Antioxidant activities of probucol against lipid peroxidations. Biochim. Biophys. Acta. 1128:1992;147-154.
9. Halliwell B., Gutterridge J.M.C. Free Radicals in Biology and Medicine. 2nd edn. 1989;Clarendon, Oxford.
10. Hayashi H., Yoshida H., Hashimoto F., Okazeri S. Changes in polyamine-oxidizing capacity of peroxisomes under various physiological conditions in rats. Biochim. Biophys. Acta. 991:1989;310-316.
11. Hess M.L., Manson N.H. Molecular oxygen: friend and foe: the role of the oxygen free radical system in the calcium paradox, the oxygen paradox and ischemia/reperfusion injury. J. Mol. Cell. Cardiol. 16:1984;969-985.
12. Horwitz L.D., Leff J. Catalase and hydrogen peroxide cytotoxicity in cardiac myocytes. J. Mol. Cell. Cardiol. 27:1995;909-915.
13. Horwitz L.D., Wallner J.S., Decker D.E., Buxser S.E. Efficacy of lipid soluble, membrane-protective agents against hydrogen peroxide cytotoxicity in cardiac myocytes. Free Rad. Biol. Med. 21:1996;743-753.
14. 2 concentrations and severity of acute lung injury. J. Appl. Physiol. 59:1985;1995-1998.
15. Janero D.R., Hreniuk D., Sharif H.M. Hydrogen peroxide-induced oxidative stress to the mammalian heart-muscle cell (cardiomyocyte): lethal peroxidative membrane injury. J. Cell Physiol. 149:1991;347-364.
16. 2+ pump activity by oxygen free radicals. Am. J. Physiol. 256:1989;H368-H374.
17. Klitzner T.S., Chen F.H., Raven R.R., Wetzel G.T., Friedman W.F. Calcium current and tension generation in immature mammalian myocardium: effects of diltiazem. J. Mol. Cell. Cardiol. 23:1991;807-815.
18. Koga T., Fukuzawa M., Suzuki Y., Akima M., Adachi Y., Tamura K., Kato T., Kuromatsu O. The protective effects of CP-060S on ischemia- and reperfusion-induced arrhythmias in anesthetized rats. Br. J. Pharmacol. 123:1998;1409-1417.
19. Loesser K.E., Kukreja R.C., Kazziha S.Y., Jesse R.L., Hess M.L. Oxidative damage to the myocardium: a fundamental mechanism of myocardial injury. Cardioscience. 2:1991;199-216.
20. Lucchesi B.R. Myocardial ischemia, reperfusion and free radical injury. Am. J. Cardiol. 65:1990;14I-23I.
21. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods. 65:1983;55-63.
22. +-metallothioneins from LEC rat liver. Biochem. Biophys. Res. Commun. 231:1997;549-552.
23. Nakaya H., Tohse N., Kanno M. Electrophysiological derangements induced by lipid peroxidation in cardiac tissue. Am. J. Physiol. 253:1987;H1089-H1097.
24. Ohya Y., Adachi N., Setoguchi M., Abe I., Fujishima M. Effects of CP-060S on membrane channels in vascular smooth muscle cells from guinea pig. Eur. J. Pharmacol. 330:1997;93-99.
25. Slezak J., Tribulova N., Pristacova J., Uhrik B., Thomas T., Khaper N., Kaul N., Singal P.K. Hydrogen peroxide changes in ischemic and reperfused heart. Cytochemistry and biochemical and X-ray microanalysis. Am. J. Pathol. 147:1995;772-781.
26. Suzuki T., Ohta M., Hoshi H. Serum-free chemistry defined medium to evaluate the direct effects of growth factors and inhibitors on proliferation and function of neonatal rat cardiac muscle cells in culture. In Vitro Cell. Dev. Biol. 25:1989;601-606.
27. Suzuki T., Tsuruda A., Katoh S., Kubodera A., Mitsui Y. Purification of endothelin from a conditioned medium of cardiac fibroblastic cells using beating rate assay of myocytes cultured in a serum-free medium. J. Mol. Cell. Cardiol. 29:1997;2087-2093.
28. 2+ channel. Eur. J. Pharmacol. 342:1998;347-351.
29. Suzuki Y., Tamura K., Akima M., Adachi Y., Fukuzawa M., Kato T. CP-060S, a novel cardioprotective drug, limits myocardial infarct size in anesthetized dogs. J. Cardiovasc. Pharmacol. 31:1998;400-407.
30. 2+ overload in cardiomyocytes and mechanical activities in vascular strips. Eur. J. Pharmacol. 312:1996;195-202.