Phase II study of a radiotherapy/etoposide combination for patients with newly malignant gliomas

Cancer Chemotherapy and Pharmacology

Volumn 44, Issue 3, 1999, Pages 210-216

  Beauchesne, P ^a   Fotso, M J ^a   Duthel, R ^a   Brunon, J ^a   Soler, C ^b   Rusch, P ^b   Schmitt, T ^b  

^a SERVICE DE NEUROLOGIE   (France)

^b NONE

Author keywords

Chemotherapy; Concurrent radiochemotherapy; Etoposide; Malignant gliomas; Newly developed brain tumors

Indexed keywords

ETOPOSIDE; GLUCOCORTICOID;

ADULT; AGED; ARTICLE; BLEEDING; BLOOD TOXICITY; BRAIN RADIOGRAPHY; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER SURGERY; CANCER SURVIVAL; CLINICAL ARTICLE; CLINICAL TRIAL; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; DRUG TOLERABILITY; FEMALE; GLIOBLASTOMA; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; MULTIMODALITY CANCER THERAPY; NEUTROPENIA; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; PROGNOSIS; SCORING SYSTEM; SEPSIS; STEREOTAXIC SURGERY; TUMOR BIOPSY;

ADULT; AGED; ANTINEOPLASTIC AGENTS, PHYTOGENIC; BRAIN NEOPLASMS; ETOPOSIDE; FEMALE; GLIOMA; HUMANS; KARNOFSKY PERFORMANCE STATUS; MALE; MIDDLE AGED; SURVIVAL ANALYSIS;

EID: 0032801012     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002800050969     Document Type: Article

References (23)

1. 1. Beauchesne P, Bertrand S, N'Guyen MJ, Christianson T, Dore JF, Mornex F, Bonner JA (1998) Etoposide sensitivity of radioresistant human glioma cell lines. Cancer Chemother Pharmacol 41: 93-97
2. 2. Black P (1991) Brain tumors. N Engl J Med 21: 1471-1476, 22: 1555-1564
3. 2. Black P (1991) Brain tumors. N Engl J Med 21: 1471-1476, 22: 1555-1564
4. 3. Boiardi A, Silvani A, Milanesi I, Botturi M, Broggi G (1991) Primary glial tumor patients treated by combining cisplatin and etoposide. J Neuro Oncol 11: 165-170
5. 4. Boiardi A, Silvani A, Milanesi I, Botturi M, Broggi G (1992) Carboplatin combined with carmustine and etoposide in the treatment of glioblastoma. Ital J Neurol Sci 13: 717-722
6. 5. Brandes A, Rigon A, Zampieri T, Ermani M, Carollo C, Altavilla G, Turazzi S, Chierichetti F, Florentino V (1998) Carboplatin and teniposide concurrent with radiotherapy in patients with glioblastoma multiforme. Cancer 82: 355-361
7. 6. Chamberlain MC (1993) Recurrent brainstem gliomas treated with oral VP 16. J Neuro Oncol 15: 133-139
8. 7. Dinapoli RP, Brown LD, Arusell RM, Earle JD, O'Fallon R, Buckner JC (1993) Phase-II comparative evaluation of PCNU and carmustine combined with radiation therapy for high grade gliomas. J Clin Oncol 11: 1316-1321
9. 8. Fine HA, Dear KBG, Loeffler JS, Black P, Canellos GP (1993) Meta-analysis of radiotherapy with and without adjuvant chemotherapy for malignant gliomas in adults. Cancer 71: 2585-2597
10. 9. Fulton D, Urtasun R, Forsyth P (1996) Phase-II study of prolonged oral therapy with etoposide (VP16) for patients with recurrent malignant gliomas. J Neuro Oncol 27: 149-155
11. 10. Giocanti N, Hennequin C, Balosso J, Mahler M, Favaudon V (1993) DNA repair and cell cycle interactions in radiation sensitization by the topoisomerase II poison etoposide. Cancer Res 53: 2105-2111
12. 11. Hainsworth JD, Greco FA (1995) Etoposide: twenty years later. Ann Oncol 6: 325-341
13. 12. Hildebrand J, Sahmoud T, Mignolet JM, Brucher JM, Afra D (1994) Adjuvant therapy with dibromodulcitol and BCNU increases survival of adults with malignant gliomas. Neurology 44: 1479-1483
14. 13. Jeremic B, Grujicic D, Jevremovic S, Stanisavljevic B, Milojevic L, Djuric L, Mijatovic L (1992) Carboplatin and etoposide chemotherapy regimen for recurrent malignant gliomas: a phase II study. J Clin Oncol 7: 1074-1077
15. 14. Levin VA, Silver P, Hannigan J, Wara WM, Gutin PH, Davis RL (1990) Superiority of post-radiotherapy adjuvant chemotherapy with CCNU, procarbazine, and vincristine (PCV) over BCNU for anaplastic gliomas. Int J Radiat Oncol Biol Phys 18: 321-324
16. 15. Levin VA, Maor MH, Thall PF, Yung WKA, Bruner J, Sawaya R (1995) Phase-II study of accelerated fractionation radiation therapy with carboplatin followed by vincristine chemotherapy for the treatment of glioblastoma multiforme. Int J Radiat Oncol Biol Phys 33: 357-364
17. 16. MacDonald DR, Cascino TL, Schold C, Cairncross JG (1990) Response criteria for phase-II studies of supratentorial malignant gliomas. J Clin Oncol 8: 1277-1280
18. 17. Madajewicz S, Chowhan N, Iliya A, Roque C, Beaton R, Davis R, Fertman S, Meek A, Alvarez O, Pampati M, Tyson G (1991) Intracarotid chemotherapy with etoposide and cisplatin for malignant brain tumours. Cancer 67: 2844-2849
19. 18. Minehan KJ, Bonner JA (1994) The interaction of etoposide with radiation: variation in cytotoxicity with the sequence of treatment. Life Sci 53: 237-242
20. 19. Mornex F, Beauchesne P, Bonner JA (1994) Association étoposide et radiothérapie: mécanismes d'interaction. Cah Oncol 3: 227-234
21. 20. Nakagawa H, Fujita T, Kubo S, Tsuruzono K, Yamada M, Tokiyoshi K, Miyawaki Y, Kanayama T, Kadota T, Hayakawa T (1994) Selective intra-arterial chemotherapy with a combination of etoposide and cisplatin for malignant gliomas: preliminary report. Surg Neurol 41: 19-27
22. 21. Shapiro WR, Green SB, Burger PC, Selker RG, Vangilder JC, Robertson JT (1992) A randomized comparison of intraarterial versus intravenous BCNU, with or without intravenous 5-fluorouracil, for newly diagnosed patients with malignant gliomas. J Neurosurg 76: 772-781
23. 22. Tirelli U, D'Incalci M, Canetta R, Tomolo S, Franchin G, Veronesi A, Galligioni E, Trovo MG, Rossi C, Grigoletto E (1984) Etoposide (VP 16-213) in malignant brain tumors: a phase II study. J Clin Oncol 2: 432-436