Glucokinase is concentrated in insulin-secretory granules of pancreatic B-cells

Histochemistry and Cell Biology

Volumn 112, Issue 1, 1999, Pages 35-40

  Toyoda, Y ^a   Shironoguchi, H ^a   Miwa, I ^a   Yoshie, S ^b  

^a MEIJO UNIVERSITY   (Japan)

^b NIPPON DENTAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOKINASE; INSULIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELLULAR DISTRIBUTION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; ELECTRON MICROSCOPY; ENZYME LOCALIZATION; IMMUNOHISTOCHEMISTRY; MALE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; RAT; SECRETORY GRANULE;

ANIMALS; CYTOPLASMIC GRANULES; GLUCOKINASE; IMMUNOENZYME TECHNIQUES; INSULIN; ISLETS OF LANGERHANS; MALE; MICROSCOPY, FLUORESCENCE; MICROSCOPY, IMMUNOELECTRON; RABBITS; RATS; RATS, WISTAR;

ANIMALIA;

EID: 0032800894     PISSN: 09486143     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004180050389     Document Type: Article

References (24)

1. Bedoya FJ, Oberholtzer JC, Matschinsky FM (1987) Glucokinase in B-cell-depleted islets of Langerhans. J Histochem Cytochem 35:1089-1093
2. Coore HG, Randle PJ (1964) Regulation of insulin secretion studied with pieces of rabbit pancreas incubated in vitro. Biochem J 93:66-78
3. Ferrand N, Demongot T, Rosselin G, Emami S (1997) Specificity of adenylyl cyclase isoforms expression in pancreatic islets and acini. Diabetologia 40(suppl 1):A113
4. Grube D, Kusumoto Y (1986) Serial semithin sections in immunohistochemistry: techniques and applications. Arch Histol Cytol 49:391-410
5. Hutton JC, Penn EJ, Peshavaria M (1983) Low-molecular-weight constituents of isolated insulin-secretory granules. Biochem J 210:297-305
6. Jetton TL, Magnuson MA (1992) Heterogeneous expression of glucokinase among pancreatic β-cells. Proc Natl Acad Sci USA 89:2619-2623
7. Jetton TL, Liang Y, Pettepher CC, Zimmerman EC, Cox FG, Horvath K, Matschinsky FM, Magnuson MA (1994) Analysis of upstream glucokinase promoter activity in transgenic mice and identification of glucokinase in rare neuroendocrine cells in the brain and gut. J Biol Chem 269:3641-3654
8. Magnuson MA, Shelton KD (1989) An alternate promoter in the glucokinase gene is active in the pancreatic β cell. J Biol Chem 264:15936-15942
9. Matschinsky FM (1990) Glucokinase as glucose sensor and metabolic signal generator in pancreatic β-cells and hepatocytes. Diabetes 39:647-652
10. Matschinsky FM, Ellerman JE (1968) Metabolism of glucose in the islets of Langerhans. J Biol Chem 243:2730-2736
11. Noma Y, Bonner-Weir S, Latimer JB, Davalli AM, Weir GC (1996) Translocation of glucokinase in pancreatic β-cells during acute and chronic hyperglycemia. Endocrinology 137:1485-1491
12. Ohnishi M, Tokuda M, Masaki T, Fujimura T, Tai Y, Matsui H, Ishida T, Konishi R, Takahara J, Hatase O (1995) Involvement of annexin-I in glucose-induced insulin secretion in rat pancreatic islets. Endocrinology 136:2421-2426
13. Randle PJ (1993) Glucokinase and candidate genes for Type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia 36:269-275
14. Spinas GA, Laffranchi R, Francoys I, David I, Richter C, Reinecke M (1998) A role for paracrine nitric oxide in the early phase of glucose-stimulated insulin secretion. Diabetologia 41:292-299
15. Toyoda Y, Miwa I, Kamiya M, Ogiso S, Nonogaki T, Aoki S, Okuda J (1994) Evidence for glucokinase translocation by glucose in rat hepatocytes. Biochem Biophys Res Commun 204:252-256
16. Toyoda Y, Miwa I, Kamiya M, Ogiso S, Nonogaki T, Aoki S, Okuda J (1995) Tissue and subcellular distribution of glucokinase in rat liver and their changes during fasting-refeeding. Histochem Cell Biol 103:31-38
17. Toyoda Y, Ito Y, Miwa I (1996a) Glucose-induced translocation of glucokinase within hepatocytes. J Japan Diabetes Soc 39(suppl 1):382
18. Toyoda Y, Ito Y, Miwa I (1996b) Translocation of glucokinase between nucleus and cytoplasm in primary cultures of rat hepatocytes. Diabetologia 39(suppl 1):A161
19. Toyoda Y, Ito Y, Yoshie S, Miwa I (1997a) Shuttling of glucokinase between the nucleus and the cytoplasm in primary cultures of rat hepatocytes: possible involvement in the regulation of the glucose metabolism. Arch Histol Cytol 60:307-316
20. Toyoda Y, Yoshie S, Fujita T, Ito Y, Nonogaki T, Miwa I (1997b) Glucokinase is located in secretory granules of pancreatic D-cells. FEBS Lett 415:281-284
21. Toyoda Y, Ito Y, Miwa I, Yoshie S, Fujita T, Nonogaki T (1998) Glucokinase is localized mainly in secretory granules of pancreatic B-and D-cells. J Japan Diabetes Soc 41(suppl 1):433
22. Weinhouse S (1976) Regulation of glucokinase in liver. Curr Top Cell Regul 11:1-50
23. Williams RH, Porte D (1974) The pancreas. In: Williams RH (ed) Textbook of endocrinology. Saunders, Philadelphia, pp 502-626
24. 2+ steady state in endoplasmic reticulum of islets. J Biol Chem 261:16284-16287