Shuttling of glucokinase between the nucleus and the cytoplasm in primary cultures of rat hepatocytes: Possible involvement in the regulation of the glucose metabolism

Archives of Histology and Cytology

Volumn 60, Issue 3, 1997, Pages 307-316

  Toyoda, Yukiyasu ^a   Ito, Yuki ^a   Yoshie, Sumio ^b   Miwa, Ichitomo ^a  

^a MEIJO UNIVERSITY   (Japan)

^b NIPPON DENTAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOKINASE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; GLUCOSE METABOLISM; INTRACELLULAR TRANSPORT; LIVER CELL; LIVER CELL NUCLEUS; LIVER CYTOSOL; MALE; NONHUMAN; PROTEIN TRANSPORT; RAT;

EID: 0030880711     PISSN: 09149465     EISSN: None     Source Type: Journal    
DOI: 10.1679/aohc.60.307     Document Type: Article

References (40)

1. AGIUS L. and M. PEAK: Intracellular binding of glucokinase in hepatocytes and translocation by glucose, fructose and insulin. Biochem. J. 296: 785-796 (1993).
2. BARZILAI, N., M. HAWKINS, I. ANGELOV, M. HU and L. ROSSETTI: Glucosamine-induced inhibition of liver glucokinase impairs the ability of hyperglycemia to suppress endogenous glucose production. Diabetes 45: 1329-1335 (1996).
3. BORER, R. A., C. F. LEHNER, H. M. EPPENBERGER and E. A. NIGG: Major nucleolar proteins shuttle between nucleus and cytoplasm. Cell 56: 379-390 (1989).
4. CLARK, D. G., O. H. FILSELL and D. L. TOPPING: Effects of fructose concentration on carbohydrate metabolism, heat production and substrate cycling in isolated rat hepatocytes. Biochem. J. 184: 501-507 (1979).
5. DAVIES, D. R., M. DETHEUX and E. van SCHAFTIXGEN: Fructose 1-phosphate and the regulation of glucokinase activity in isolated hepatocytes. Eur. J. Biochem. 192: 283-289 (1990).
6. DWORETZKY, S. I. and C. M. FELDHERR: Translocation of RNA-coated gold particles through the nuclear pores of oocytes. J. Cell Biol. 106: 575-584 (1988).
7. EKMAN, P. and E. NILSSON: Phosphorylation of glucokinase from rat liver in vitro by protein kinase A with a concomitant decrease of its activity. Arch. Biochem. Biophys. 261: 275-282 (1988).
8. FERRE, T., F. RIU, F. BOSCH and A. VALERA: Evidence from transgenic mice that glucokinase is rate limiting for glucose utilization in the liver. FASEB J. 10: 1213-1218 (1996).
9. FILLAT, C., A. M. GÓMEZ-FOIX and J. J. GUINOV ART: Stimulation of glucose utilization by fructose in isolated rat hepatocytes. Arch. Biochem. Biophys. 300: 564-569 (1993).
10. GROSSMAN, S. H., C. G. DORN and V. R. POTTER: The preparation and characterization of pure rat liver glucokinase. J. Biol. Chem. 249: 3055-3060 (1974).
11. HICKS, G. R and N. V. RAIKHEL: Protein import into the nucleus: an integrated view. Cell. Devel. Biol. 11: 55-88 (1995).
12. JANS, D. A.: The regulation of protein transport to the nucleus by phosphorylation. Biochem. J. 311: 705-716 (1995).
13. JANS, D. A. and S. HÜBNER: Regulation of protein transport to the nucleus: central role of phosphorylation. Physiol. Rev. 76: 651-685 (1996).
14. JETTON, T. L., Y. LIANG, C. C. PETTEPHER, E. C. ZIMMERMAN, F. G. COX, K. HORVATH, F. M. MATSCHINSKY and M. A. MAGNUSON: Analysis of upstream glucokinase promoter activity in transgenic mice and identification of glucokinase in rare neuroendocrine cells in the brain and gut. J. Biol. Chem. 269: 3641-3654 (1994).
15. KNULL, H. R. and J. L. WALSH: Association of glycolytic enzymes with the cytoskeleton. Curr. Top. Cell. Regul. 33: 15-30 (1992).
16. LACHALL, M., R. A. SPANGLER and C. Y. JUNG: High Km of GLUT-2 glucose transporter does not explain its role in insulin secretion. Amer. J. Physiol. 265: E914-E919 (1993).
17. MADAN, A. P. and D. B. DEFRANCO: Bidirectional transport of glucocorticoid receptors across the nuclear envelope. Proc. Nat. Acad. Sci. USA 90: 3588-3592 (1993).
18. MANDELL, R. B. and C. M. FELDHERR: Identification of two HSP70-related Xenopus oocyte proteins that are capable of recycling across the nuclear envelope. J. Cell Biol. 111: 1775-1783 (1990).
19. MASTERS, C. J., S. REID and M. DON: Glycolysis - new concepts in an old pathway. Mol. Cell. Biochem. 76: 3-14 (1987).
20. MATSCHINSKY, F. M: Glucokinase as glucose sensor and metabolic signal generator in pancreatic β-cells and hepatocytes. Diabetes 39: 647-652 (1990).
21. MEINKOTH, J. L., Y. JI, S. S. TAYLOR and J. R. FERAMISCO: Dynamics of the distribution of cyclic AMP-dependent protein kinase in living cells. Proc. Nat. Acad. Sci. USA 87: 9595-9599 (1990).
22. MIWA, I., S. MITSUYAMA, Y. TOYODA, T. NONOGAKI, S. AOKI and J. OKUDA: Evidence for the presence of rat liver glucokinase in the nucleus as well as in the cytoplasm. Biochem. Int. 22: 759-767 (1990).
23. NEWGARD, C. B., C. QUAADE, S. D. HUGHES and J. L. MILBURN: Glucokinase and glucose transporter expression in liver and islets: implications for control of glucose homeostasis. Biochem. Soc. Trans. 18: 851-853 (1990).
24. PARRY, M. J and D. G. WALKER: Purification and properties of adenosine 5′-triphosphate-D-glucose 6-phosphotransferase from rat liver. Biochem. J. 99: 266-274 (1966).
25. PIÑOL-ROMA, S. and G. DREYFUSS: Shuttling of premRNA binding proteins between nucleus and cytoplasm. Nature 355: 730-732 (1992).
26. PRINTZ, R. L., M. A. MAGNUSON and D. K. GRANNER: Mammalian glucokinase. Annu. Rev. Nutr. 13: 463-496 (1993).
27. SINGH, R. and M. R. GREEN: Sequence-specific binding of transfer RNA by glyceraldehyde-3-phosphate dehydrogenase. Science 259: 365-368 (1993).
28. TANAKA, K., M. SATO, Y. TOMIYA and A. ICHIHARA: Biochemical studies on liver functions in primary cultured hepatocytes of adult rats. J. Biochem. 84: 937-946 (1978).
29. TIPPETT, P. S. and K. E. NEET: Specific inhibition of glucokinase by long chain acyl coenzymes A below the critical micelle concentration. J. Biol. Chem. 257: 12839-12845 (1982).
30. TOYODA, Y., I. MIWA, M. KAMIYA, S. OGISO, T. NONOGAKI, S. AOKI and J. OKUDA: Evidence for glucokinase translocation by glucose in rat hepatocytes. Biochem. Biophys. Res. Commun. 204: 252-256 (1994).
31. _ _ _ _ _ _ _: Tissue and subcellular distribution of glucokinase in rat liver and their changes during fasting refeeding. Histochemistry 103: 31-38 (1995a).
32. TOYODA, Y., I. MIWA, M. KAMIYA, S. OGISO, J. OKUDA and T. NONOGAKI: Changes in subcellular and zonal distribution of glucokinase in rat liver during postnatal development. FEBS Lett. 359: 81-84 (1995b).
33. TOYODA, Y., I. MIWA, S. SATAKE, M. ANAI and Y. OKA: Nuclear location of the regulatory protein of glucokinase in rat liver and translocation of the regulator to the cytoplasm in response to high glucose. Biochem. Biophys. Res. Commun. 215: 467-473 (1995c).
34. TOYODA, Y., Y. ITO and I. MIWA: Glucose-induced translocation of glucokinase within hepatocytes. J. Japan Diab. Soc. 39 (Suppl. 1): 382 (1996a).
35. _ _ _: Translocation of glucokinase between nucleus and cytoplasm in primary cultures of rat hepatocytes. Diabetologia 39 (Suppl. 1): A161 (1996b).
36. VANDERCAMMEN, A. and E. van SCHAFTINGEN: Competitive inhibition of liver glucokinase by its regulatory protein. Eur. J. Biochem. 200: 545-551 (1991).
37. van SCHAFTINGEN, E: A protein from rat liver confers to glucokinase the property of being antagonistically regulated by fructose 6-phosphate and fructose 1-phosphate. Eur. J. Biochem. 179: 179-184 (1989).
38. van SCHAFTINGEN, E. and A. VANDERCAMMEN: Stimulation of glucose phosphorylation by fructose in isolated rat hepatocytes. Eur. J. Biochem. 179: 173-177 (1989).
39. van SCHAFTINGEN, E., M. DETHEUX and M. V. DA CUNHA: Short-term control of glucokinase activity: role of a regulatory protein. FASEB J. 8: 414-419 (1994).
40. WEINHOUSE, S.: Regulation of glucokinase in liver. Curr. Top. Cell Regul. 11: 1-50 (1976).