Thymidine phosphorylase expression in progression of cervical cancer: Correlation with microvessel count, proliferating cell nuclear antigen, and apoptosis

Journal of Clinical Pathology

Volumn 52, Issue 8, 1999, Pages 598-603

  Fujiwaki, Ritsuto ^a   Hata, Kohkichi ^a   Iida, Kohji ^a   Maede, Yoshinobu ^a   Koike, Mikio ^a   Miyazaki, Kohji ^a  

^a SHIMANE UNIVERSITY   (Japan)

Author keywords

Cervical cancer; Microvessel count; Proliferating cell nuclear antigen; Thymidine phosphorylase

Indexed keywords

CYCLINE; THYMIDINE PHOSPHORYLASE;

APOPTOSIS; ARTICLE; CANCER INVASION; EPITHELIUM CELL; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MICROVASCULATURE; PRIORITY JOURNAL; PROTEIN EXPRESSION; STROMA CELL; UTERINE CERVIX CANCER; UTERINE CERVIX CARCINOMA IN SITU;

EID: 0032799375     PISSN: 00219746     EISSN: None     Source Type: Journal    
DOI: 10.1136/jcp.52.8.598     Document Type: Article

References (30)

1. Hanahan D, Folkman J. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 1996;86:353-6.
2. Ishikawa F, Miyazono K, Hellman U, et al. Identification of angiogenetic activity and the cloning and expression of platelet-derived endothelial cell growth factor. Nature 1989;38:557-62.
3. Moghaddam A, Zhang HT, Fan TP, et al. Thymidine phosphorylase is angiogenic and promotes tumor growth. Proc Natl Acad Sci USA 1995;92:998-1002.
4. Haraguchi M, Kazutaka M, Uemura K, et al. Angiogenic activity of enzymes. Nature 1994;368:198.
5. Toi M, Hoshina S, Taniguchi T, et al. Expression of platelet-derived endothelial cell growth factor/thymidine phosphorylase in human breast cancer. Int J Cancer 1995;64:79-82.
6. Takebayashi Y, Akiyama S, Akiba S, et al. Clinicopathologic and prognostic significance of an angiogenic factor, thymidine phosphorylase, in human colorectal carcinoma. J Natl Cancer Inst 1996;88:1110-17.
7. Fujiwaki R, Hata K, Iida K, et al. Immunohistochemical expression of thymidine phosphorylase in human endometrial cancer. Gynecol Oncol 1998;68:247-52.
8. Imazono Y, Takebayashi Y, Nishiyama K, et al. Correlation between thymidine phosphorylase expression and prognosis in human renal cell carcinoma. J Clin Oncol 1997;15: 2870-8.
9. Takahashi Y, Bucana CD, Liu W, et al. Platelet-delivered endothelial cell growth factor in human colon cancer angiogenesis: role of infiltrating cells. J Natl Cancer Inst 1996;88:1146-51.
10. Takahashi Y, Bucana CD, Akagi Y, et al. Significance of platelet-derived endothelial cell growth factor in the angiogenesis of human gastric cancer. Clin Cancer Res 1998;4: 429-34.
11. Koukourakis MI, Giatromanolaki A, Kakolyris S, et al. Different patterns of stromal and cancer cell thymidine phosphorylase reactivity in non-small-cell lung cancer: impact on tumour neoangiogenesis and survival. Br J Cancer 1998; 77:1696-703.
12. Engels K, Fox SB, Whitehouse RM, et al. Distinct angiogenic patterns are associated with high-grade in situ ductal carcinomas of the breast. J Pathol 1997;181:207-12.
13. Nishimoto K, Miyadera K, Takebayashi Y, et al. Thymidine phosphorylase activity required for tumor angiogenesis and growth. Oncol Rep 1997;4:55-8.
14. Takebayashi Y, Akiyama S, Tani A, et al. Induction of thymidine phosphorylase by hypoxia and relationship between expression of thymidine phosphorylase and apoptosis. Proc Am Assoc Cancer Res 1997;38:48.
15. Hall PA, Levison DA, Woods AL, et al. Proliferating cell nuclear antigen (PCNA) immunolocalization in paraffin sections: an index of cell proliferation with evidence of deregulated expression in some neoplasms. J Pathol 1990;162:285-94.
16. Shepherd JH. Cervical and vulva cancer: changes in FIGO definitions of staging. Br J Obstet Gynaccol 1996;103:405-6.
17. Nishida M, Hino A, Mori K, et al. Preparation of anti-human thymidine phosphorylase monoclonal antibodies useful for detecting the enzyme levels in tumor tissues. Biol Pharm Bull 1996;19:1407-11.
18. Guidi AJ, Abu-Jawdeh G, Berse B, et al. Vascular permeability factor (vascular endothelial growth factor) expression and angiogenesis in cervical neoplasia. J Natl Cancer Inst 1995;87:1237-15.
19. Lu C, Tanigawa N. Spontaneous apoptosis is inversely related to intratumoral microvessel density in gastric carcinoma. Cancer Res 1997;57:221-4.
20. Tokumo K, Kodama J, Seki N, et al. Different angiogenic pathways in human cervical cancers. Gynecol Oncol 1998;68:38-44.
21. Dobbs SP, Hewett PW, Johnson IR, et al. Angiogenesis is associated with vascular endothelial growth factor expression in cervical intraepithelial neoplasia. Br J Cancer 1997; 76:1410-15.
22. Obermair A, Bancher-Todesca D, Biligi S, et al. Correlation of vascular endothelial growth factor expression and microvessel density in cervical intraepithelial neoplasia. J Natl Cancer Inst 1997;89:1212-17.
23. Heatley MK. What is the value of proliferation markers in the normal and neoplastic cervix? Histol Histopathol 1998;13:249-54.
24. Hu G, Liu W, Mendelsohn J, et al. Expression of epidermal growth factor receptor and human papillomavirus E6/E7 proteins in cervical carcinoma cells. J Natl Cancer Inst 1997;89:1243-6.
25. Nakano T, Oka K, Ishikawa A, et al. Correlation of cervical carcinoma c-erb B-2 oncogene with cell proliferation parameters in patients treated with radiation therapy for cervical carcinoma. Cancer 1997;79:513-20.
26. Dellas A, Schultheiss E, Almendral AC, et al. Altered expression of mdm-2 and its association with p53 protein status, tumor-cell-proliferation rate and prognosis in cervical neoplasia. Int J Cancer 1997;74:421-5.
27. Shoji Y, Saegusa M, Takano Y, et al. Correlation of apoptosis with tumour cell differentiation, progression, and HPV infection in cervical carcinoma. J Clin Pathol 1996;49:134-8.
28. Ueda M, Ueki K, Kumagai K, et al. Apoptosis and tumor angiogenesis in cervical cancer after preoperative chemotherapy. Cancer Res 1998;58:2343-6.
29. Holzman D. Apoptosis provides new targets for chemotherapy. J Natl Cancer Inst 1996;88:1098-100.
30. Eda H, Fujimoto K, Watanabe S, et al. Cytokines induce thymidine phosphorylase expression in tumor cells and make them more susceptible to 5′-deoxy-5-fluorouridine. Cancer Chemother Pharmacol 1993;32:333-8.