Total-body irradiation and melphalan is a safe and effective conditioning regimen for autologous bone marrow transplantation in children with acute myeloid leukemia in first remission

Journal of Clinical Oncology

Volumn 17, Issue 12, 1999, Pages 3729-3735

  Bonetti, F ^a   Zecca, M ^a   Pession, A ^a   Messina, C ^a   Montagna, D ^a   Lanino, E ^a   Fagioli, F ^a   Santoro, N ^a   Prete, A ^a   Cesaro, S ^a   Rondelli, R ^a   Giorgiani, G ^a   De Stefano, P ^a   Locatelli, F ^a  

^a UNIVERSITY OF PAVIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 2; MELPHALAN;

ACUTE GRANULOCYTIC LEUKEMIA; ADOLESCENT; ADULT; ARTICLE; AUTOLOGOUS BONE MARROW TRANSPLANTATION; BONE MARROW PURGING; CANCER SURVIVAL; CATARACT; CHILD; CHILDHOOD CANCER; CLINICAL TRIAL; DRUG EFFICACY; DRUG SAFETY; FEMALE; GROWTH HORMONE DEFICIENCY; HUMAN; HYPOGONADISM; HYPOTHYROIDISM; MAJOR CLINICAL STUDY; MALE; MUCOSA INFLAMMATION; PREOPERATIVE TREATMENT; PRIORITY JOURNAL; WHOLE BODY RADIATION;

EID: 0032798966     PISSN: 0732183X     EISSN: None     Source Type: Journal    
DOI: 10.1200/JCO.1999.17.12.3729     Document Type: Article

References (31)

1. Vormoor J, Boos J, Stahnke K, et al: Therapy of childhood acute myelogenous leukemia. Ann Hematol 73:11-24, 1996
2. Hurwitz CA, Mounce KG, Grier HE: Treatment of patients with acute myelogenous leukemia: Review of clinical trials of the past decade. J Pediatr Hematol Oncol 17:185-187, 1995
3. Mandelli F, Meloni G, Testi AM, et al: Therapy of acute nonlymphocytic leukemia in children: The AIEOP experience, in Acute Myelogenous Leukemia: Progress and Controversies. New York, NY, Wiley-Liss, 1990, pp 175-191
4. Stevens RF, Hann IM, Wheatley K, et al: Marked improvement in outcome with chemotherapy alone in pediatric acute myeloid leukemia: Results of the United Kingdom Medical Research Council's 10th AML trial. Br J Haematol 101:130-140, 1998
5. Ravindranath Y, Yeager AM, Chang MN, et al: Autologous bone marrow transplantation versus intensive consolidation chemotherapy for acute myeloid leukemia in childhood. N Engl J Med 334:1428-1434, 1996
6. Amadori S, Testi AM, Aricò M, et al: Prospective comparative study of bone marrow transplantation and post-remission chemotherapy for childhood acute myelogenous leukemia. J Clin Oncol 11:1046-1054, 1993
7. Creutzig U, Ritter J, Schellong G for the AML-BFM Study Group: Identification of two risk groups in childhood acute myelogenous leukemia after therapy intensification in study AML-BFM-83 compared with AML-BFM-78. Blood 75:1932-1940, 1990
8. Burnett AK, Goldstone AH, Stevens RM, et al: Randomized comparison of addition of autologous bone-marrow transplanation to intensive chemotherapy for acute myeloid leukemia in first remission: Results of MRC AML 10 trial. Lancet 351:700-708, 1998
9. Michel G, Leverger L, Leblanc T, et al: Allogeneic bone marrow transplantation vs. aggressive post-remission therapy for children with acute myeloid leukemia in first complete remission: A prospective study from the French Society of Pediatric Hematology and Immunology (SHIP). Bone Marrow Transplant 17:191-196, 1996
10. Gorin NC: Autologous stem cell transplantation in acute myelocytic leukemia. Blood 92:1073-1090, 1998
11. Vignetti M, Rondelli R, Locatelli F, et al: Autologous bone marrow transplantation in children with acute myeloblastic leukemia: Report from the Italian National Pediatric Registry (AIEOP-BMT). Bone Marrow Transplant 18:59-62, 1996 (suppl 2)
12. Giorgiani G, Bozzola M, Locatelli F, et al: Role of busulfan and total body irradiation on growth of pre-pubertal children receiving bone marrow transplantation and results of treatment with recombinant human growth hormone. Blood 86:825-831, 1995
13. Parth P, Kennedy RS, Lane NE, et al: Motor and cognitive testing of bone marrow transplant patients after chemo-radiotherapy. Percept Mot Skills 68:1227-1241, 1989
14. Bonetti F, Montagna D, Porta F, et al: Autologous bone marrow transplantation for acute myeloid leukaemia in children using total body irradiation and melphalan as conditioning regimen. Leukemia 9:570-575, 1995
15. Bennet JM, Catowsky D, Daniel MT: Proposal for the classification of the acute leukemia: French-American-British co-operative group. Br J Haematol 33:451-458, 1976
16. Messina C, Zambello R, Rossetti F, et al: Interleukin-2 before and/or after autologous bone marrow transplantation for pediatric acute leukemia patients. Bone Marrow Transplant 17:729-735, 1996
17. Creutzig U, Zimmermann M, Ritter J, et al: Definition of a standard-risk group in children with AML. Br J Haematol 104:630-639, 1999
18. Bearman SI, Appelbaum FR, Buckner CD, et al: Regimen-related toxicity in patients undergoing bone marrow transplantation. J Clin Oncol 6:1562-1568, 1988
19. Powles RL, Smith CL, Tiley C, Findlay M, O'Brien M: The anti-leukemia action of melphalan and total body irradiation in bone marrow transplantation. Hematol Rev 4:23-26, 1990
20. Pinkerton RCR, Groot-Loonen J, Barrett AJ, et al: Rapid VAC, high-dose melphalan regimen: A novel chemotherapy approach in childhood soft-tissue sarcoma. Br J Cancer 64:381-385, 1991
21. Tiedemann K, Waters KD, Tavro GP, et al: Results of intensive therapy in childhood acute myeloid leukemia incorporating high dose melphalan and autologous bone marrow transplantation in first complete remission. Blood 82:3730-3738, 1993
22. st CR for childhood AML: An RCH update. Blood 88:126, 1996 (suppl 1; abstr)
23. Yaniv I, Ash S, Stark B, et al: Childhood acute myeloid leukemia. Consolidation with high dose melphalan and autologous stem cell transplantation: A single centre experience. Bone Marrow Transplant 19:101, 1997 (suppl 1; abstr)
24. Creutzig U, Ritter J, Zimmerman M: Does cranial irradiation reduce the risk of bone marrow relapse in acute myelogenous leukemia: Unexpected results of the Childhood Acute Myelogenous Leukemia study BFM 87. J Clin Oncol 11:279-286, 1993
25. Dini G, Boni L, Abla C, et al: Allogeneic bone marrow transplantation in children with acute myelogenous leukemia in first remission. Bone Marrow Transplant 13:771-776, 1994
26. Nesbit ME, Buckley JD, Feig SA, et al: Chemotherapy for induction of remission of childhood acute myeloid leukemia followed by multiagent chemotherapy: A report from Children Cancer Group. J Clin Oncol 12:127-135, 1994
27. Woods WG, Kobrinsky N, Buckley J, et al: Intensively timed induction therapy followed by autologous or allogeneic bone marrow transplantation for children with acute myeloid leukemia or myelodys-plastic syndrome: A Children Cancer Group pilot study. J Clin Oncol 11:1148-1157, 1993
28. Brenner MK, Rill DR, Moen RC, et al: Gene-marking to trace origin of relapse after autologous bone-marrow transplantation. Lancet 341:85-89, 1993
29. Gorin NC, Aegerter P, Auvert B, et al: Autologous bone marrow transplantation for acute myelocytic leukemia in first remission: A European survey of the role of marrow purging. Blood 75:1606-1614, 1990
30. Gorin NC, Labopin M, Meloni G, et al: Autologous bone marrow transplantation for acute myeloblastic leukemia in Europe: Further evidence of the role of marrow purging by mafosfamide. Leukemia 5:896-904, 1991
31. Lowenberg B, Verdonck LJ, Dekker AW, et al: Autologous bone marrow transplantation for acute myeloid leukemia in first remission: Results of a Dutch prospective study. J Clin Oncol 8:287-295, 1990