Randomised comparison of addition of autologous bone-marrow transplantation to intensive chemotherapy for acute myeloid leukaemia in first remission: Results of MRC AML 10 trial

Lancet

Volumn 351, Issue 9104, 1998, Pages 700-708

  Burnett, Alan K ^b   Goldstone, Anthony H ^c   Stevens, Richard M F ^c   Hann, Ian M ^c   Rees, John K H ^a   Gray, Richard G ^c   Wheatley, Keith ^c  

^a MEDICAL RESEARCH COUNCIL   (United Kingdom)

^b CARDIFF UNIVERSITY   (United Kingdom)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

AMSACRINE; ANTINEOPLASTIC AGENT; CYCLOPHOSPHAMIDE; CYTARABINE; DAUNORUBICIN; ETOPOSIDE; MITOXANTRONE; TIOGUANINE;

ACUTE GRANULOCYTIC LEUKEMIA; ADOLESCENT; ADULT; ARTICLE; AUTOLOGOUS BONE MARROW TRANSPLANTATION; CANCER SURVIVAL; CHILD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; FEMALE; HUMAN; INFANT; LEUKEMIA REMISSION; MAJOR CLINICAL STUDY; MALE; MULTIMODALITY CANCER THERAPY; NEWBORN; PRESCHOOL CHILD; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; RECURRENCE RISK; SCHOOL CHILD; WHOLE BODY RADIATION;

EID: 0032492441     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(97)09214-3     Document Type: Article

References (25)

1. 1 Rees JKH, Gray RG, Wheatley K. Dose intensity in acute myeloid leukemia: greater effectiveness at lower cost. Principal report of the MRC's AML 9 Study. Br J Haematol 1996; 94: 89-98.
2. 2 Bishop JF, Matthews JP, Young GA, et al. A randomized study of high-dose cytarabine in induction in acute myeloid leukemia. Blood 1996; 87: 1710-17.
3. 3 Mayer RJ, Davis RB, Schiffer CA, et al. Intensive postremission chemotherapy in adults with acute myeloid leukemia. N Engl J Med 1994; 331: 896-942.
4. 4 Hann IM, Stevens RF, Goldstone AH, et al. Randomized comparison of DAT versus ADE as induction chemotherapy in children and younger adults with acute myeloid leukaemia: results of the Medical Research Council's 10th AML Trial (MRC AML 10). Blood 1997; 89: 2311-18.
5. 5 Buchner T, Urbanitz D, Hiddemann W, et al. Intensive induction and consolidation with or without maintenance chemotherapy for acute myeloid leukaemia (AML): two multicenter studies of German AML Cooperative Group. J Clin Oncol 1985; 3: 1583-89.
6. 6 Clift RA, Buckner CD, Thomas ED, et al. The treatment of acute non-lymphoblastic leukemia by allogeneic marrow transplantation. Bone Marrow Transplant 1987; 2: 243-58.
7. 7 Applebaum FR, Fisher LD, Thomas ED. Chemotherapy v marrow transplantation for adults with acute non-lymphocytic leukemia: a five-year follow-up. Blood 1988; 72: 179-84.
8. 8 Santos GW, Tutschka PJ, Brookmeyer R, et al. Marrow transplantation for acute non-lymphocytic leukemia after treatment with busulphan and cyclophosphamide. N Engl J Med 1983; 309: 1347-53.
9. 9 Burnett AK, Tansey P, Watkins R, et al. Transplantation of unpurged autologous bone marrow in acute myeloid leukaemia in first remission. Lancet 1984; ii: 1068-70.
10. 10 Stewart R, Buckner C, Bensinger W, et al. Autologous marrow transplantation in patients with acute non-lymphocytic leukaemia in first remission. Exp Haematol 1985; 13: 267-72.
11. 11 Goldstone AH, Anderson CC, Linch DC, et al. Autologous bone marrow transplantation following high dose therapy for the treatment of adult patients with acute myeloid leukaemia. Br J Haematol 1986; 64: 529-37.
12. 12 Lowenberg B, Verdonk LJ, Dekker AW, et al. Autologous bone marrow transplantation in acute myeloid leukaemia in first remission: results of a Dutch prospective study. J Clin Oncol 1990; 8: 287-94.
13. 13 Carella AM, Gaozza E, Santini G, et al. Autologous unpurged bone marrow transplantation for acute non-lymphoblastic leukemia in first complete remission. Bone Marrow Transplant 1988; 3: 537-41.
14. 14 Gray R, Wheatley K. How to avoid bias when comparing bone marrow transplantation with chemotherapy. Bone Marrow Transplant 1991; 7 (suppl 3): 9-12.
15. 15 Wheatley K, Burnett A, Goldstone A, et al. A simple robust and highly predictive prognostic index for the determination of risk directed therapy in acute myeloid leukaemia (AML) derived from the United Kingdom Medical Research Council (MRC) AML 10 Trial. Blood 1995; 86: 598 (abstr).
16. 16 Zittoun RA, Mandelli F, Willemze R, et al. Autologous or allogeneic bone marrow transplantation compared with intensive chemotherapy in acute myelogenous leukemia. N Engl J Med 1995; 332: 217-23.
17. 17 Ravidranath Y, Yeager AM, Chang MN, et al. Autologous bone marrow transplantation versus intensive consolidation chemotherapy for acute myeloid leukemia in childhood. N Engl J Med 1996; 334: 1428-34.
18. 18 Harousseau JL, Pignon B, Witz F, et al. Prospective comparison of allogeneic bone marrow transplantation, intensive consolidation chemotherapy and unpurged autologous bone marrow transplantation as post remission therapy in adult acute myeloid leukaemia. Blood 1994; 84 (suppl 1): 251 (abstr 991).
19. 19 Woods WG, Kobrinsky N, Buckley J, et al. Timing intensive induction therapy improves post-remission outcome in acute myeloid leukemia (AML) irrespective of the use of bone marrow transplantation (BMT). Blood 1994; 84 (suppl 1): 232 (abstr 912).
20. 20 Amadori S, Testi AM, Arico M, et al. Prospective comparative study of bone marrow transplantation and post remission chemotherapy for childhood acute myelogenous leukaemia. J Clin Oncol 1993; 11: 1046-54.
21. 21 Reiffers J, Gaspard MH, Maraninchi D, et al. Comparison of allogeneic or autologous bone marrow transplantation and chemotherapy in patients with acute myeloid leukaemia in first remission: a prospective controlled trial. Br J Haematol 1989; 72: 57-63.
22. 22 Gorin NC, Aegerter P, Auvert B, et al. Autologous bone marrow transplantation for acute myelocytic leukaemia in first remission: a European survey of the role of marrow purging. Blood 1990; 75: 1606-14.
23. 23 Rowlings PA, Keating A, Horowitz MM, Zhang MJ, Armitage JO, for NAABMTR. Autotransplants for acute myelogenous leukemia (AML) in North America. Exp Hematol 1994; 22: 762 (abstr).
24. 24 Pendry K, Alcorn MJ, Burnett AK. Factors influencing haematological recovery in 53 patients with acute myeloid leukaemia in first remission after autologous bone marrow transplantation. Br J Haematol 1993; 83: 45-52.
25. 25 Demirer T, Buckner CD, Applebaum FR, et al. Rapid engraftment after autologous transplantation utilizing marrow and recombinant granulocyte colony-stimulating factor-mobilized peripheral blood stem cells in patients with acute myelogenous leukemia. Bone Marrow Transplant 1995; 15: 915-22.