Cell surface binding of LBP-LPS complexes to a protein component distinct from CD14

Journal of Endotoxin Research

Volumn 5, Issue 1-2, 1999, Pages 52-55

  Tapping, Richard I ^a   Tobias, Peter S ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; BINDING PROTEIN; CARBOHYDRATE BINDING PROTEIN; CD14 ANTIGEN; ENDOTOXIN; LIPOPOLYSACCHARIDE; LIPOPOLYSACCHARIDE BINDING PROTEIN; MEMBRANE ANTIGEN; MEMBRANE RECEPTOR; PROTEINASE K; TRYPSIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIGEN EXPRESSION; CELL ACTIVATION; CHO CELL; CONFERENCE PAPER; CONTROLLED STUDY; INTERNALIZATION; ISOTOPE LABELING; NONHUMAN;

ANIMALIA;

EID: 0032798257     PISSN: 09680519     EISSN: None     Source Type: Journal    
DOI: 10.1177/09680519990050010101     Document Type: Conference Paper

References (15)

1. Tobias P, Soldau K, Ulevitch R. Isolation of a lipopolysaccharide-binding acute phase reactant from rabbit serum. J Exp Med 1986; 164: 777.
2. Schumann RR, Leong SR, Flaggs GW et al. Structure and function of lipopolysaccharide binding protein. Science 1990; 249: 1429.
3. Hailman E, Lichenstein HS, Wurfel MM et al. Lipopolysaccharide (LPS)-binding protein accelerates the binding of LPS to CD14. J Exp Med 1994; 179: 269.
4. Tobias PS, Soldau K, Gegner JA, Mintz D, Ulevitch RJ. Lipopolysaccharide binding protein-mediated complexation of lipopolysaccharide with soluble CD14. J Biol Chem 1995; 270:10482.
5. Wright SD, Ramos RA, Tobias PS, Ulevitch RJ, Mathison JC. CD14 serves as the cellular receptor for complexes of lipopolysaccharide with lipopolysaccharide binding protein. Science 1990; 249: 1431.
6. Wright SD, Tobias PS, Ulevitch RJ, Ramos RA. Lipopolysaccharide (LPS) binding protein opsonizes LPS-bearing particles for recognition by a novel receptor on macrophages. J Exp Med 1989; 170: 1231.
7. Grunwald U, Fan X, Jack RS et al. Monocytes can phagocytose Gram-negative bacteria by a CD14-dependent mechanism. J Immunol 1996; 157: 4119.
8. Schiff DE, Kline L, Soldau K et al. Phagocytosis of Gram-negative bacteria by a unique CD14-dependent mechanism. J Leukoc Biol 1998; 62: 786.
9. Gegner JA, Ulevitch RJ, Tobias PS. LPS signal transduction and clearance. Dual roles for LBP and mCD14. J Biol Chem 1995; 270: 5320.
10. Luchi M, Munford RS. Binding, internalization, and deacylation of bacterial lipopolysaccharide by human neutrophils. J Immunol 1993; 151:v959.
11. Poussin C, Foti M, Carpentier J-L, Pugin J. CD14-dependent endotoxin internalization via a macropinocytic pathway. J Biol Chem 1998; 273: 20285.
12. Lamping N, Hoess A, Yu B et al. Effects of site-directed mutagenesis of basic residues (Arg 94, Lys 95, Lys 99) of lipopolysaccharide (LPS)-binding protein on binding and transfer of LPS and subsequent immune cell activation. J Immunol 1996; 157: 4648.
13. Kitchens RL, Munford RS. CD14-dependent internalization of bacterial lipopolysaccharide (LPS) is strongly influenced by LPS aggregation but not by cellular responses to LPS. J Immunol 1998; 160: 1920.
14. Tapping RI, Tobias PS. Cellular binding of soluble CD14 requires lipopolysaccharide (LPS) and LPS-binding protein. J Biol Chem 1997; 272: 23157.
15. Vasselon T, Pironkova R, Detmers PA. Sensitive responses of leukocytes to lipopolysaccharide require a protein component distinct from CD14 at the cell surface. J Immunol 1997; 159: 4498.