The coronary endothelium: A target for vascular endothelial growth factor. Human coronary artery endothelial cells express functional receptors for vascular endothelial growth factor in vitro and in vivo

Laboratory Investigation

Volumn 79, Issue 8, 1999, Pages 985-991

  Kranz, Andrea ^a   Mayr, Ulrike ^a   Frank, Hedwig ^a   Waltenberger, Johannes ^a  

^a UNIVERSITY HOSPITAL ULM   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

VASCULOTROPIN; VASCULOTROPIN RECEPTOR;

ANGIOGENESIS; ARTERY ENDOTHELIUM; ARTICLE; CELL PROLIFERATION; CORONARY ARTERY; CORONARY ARTERY BLOOD FLOW; ENDOTHELIUM CELL; GENE THERAPY; HEART PERFORMANCE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; PRIORITY JOURNAL; RECEPTOR AFFINITY; SCATCHARD PLOT;

ANIMALS; CELL DIVISION; CELL MOVEMENT; CELLS, CULTURED; CORONARY VESSELS; DNA; ENDOTHELIAL GROWTH FACTORS; ENDOTHELIUM, VASCULAR; HUMANS; LYMPHOKINES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS; RABBITS; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTORS, GROWTH FACTOR; RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR; RNA, MESSENGER; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 0032797431     PISSN: 00236837     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Asahara T, Bauters C, Pastore C, Kearney M, Rossow S, Bunting S, Ferrara N, Symes JF, and Isner JM (1995). Local delivery of vascular endothelial growth factor accelerates reendothelialization and attenuates intimal hyperplasia in balloon-injured rat carotid artery. Circulation 91:2793-2801.
2. Banai S, Jaklitsch MT, Shou M, Lazarous DF, Scheinowitz M, Biro S, Epstein SE, and Unger EF (1994a). Angiogenic-induced enhancement of collateral blood flow to ischemic myocardium by vascular endothelial growth factor in dogs. Circulation 89:2183-2189.
3. Banai S, Shweiki D, Pinson A, Chandra M, Lazarovici G, and Keshet E (1994b). Upregulation of vascular endothelial growth factor expression induced by myocardial ischaemia: Implications for coronary angiogenesis. Cardiovasc Res 28: 1176-1179.
4. Barleon B, Hauser S, Schöllmann C, Weindel K, Marmé D, Yayon A, and Weich HA (1993). Differential expression of the two VEGF receptors fit and KDR in placenta and vascular endothelial cells. J Cell Biochem 54:56-66.
5. Baumgartner I, Pieczek A, Manor O, Blair R, Kearney M, Walsh K, and Isner JM (1998). Constitutive expression of phVEGF(165) after intramuscular gene transfer promotes collateral vessel development in patients with critical limb ischemia. Circulation 97:1114-1123.
6. Callow AD, Choi ET, Trachtenberg JD, Stevens SL, Connolly DT, Rodi C, and Ryan US (1994). Vascular permeability factor accelerates endothelial regrowth following balloon angioplasty. Growth Factors 10:223-228.
7. Carmeliet P, Ferreira V, Breier G, Pollefeyt S, Kieckens L, Gertsenstein M, Fahrig M, Vandenhoeck A, Harpal K, Eberhardt C, Declercq C, Pawling J, Moons L, Collen D, Risau W, and Nagy A (1996). Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature 380:435-439.
8. Clauss M, Weich H, Breier G, Knies U, Röckl W, Waltenberger J, and Risau W (1996). The vascular endothelial growth factor receptor FLT-1 mediates biological activities: Implications for a functional role of placenta growth factor in monocyte activation and chemotaxis. J Biol Chem 271: 17629-17634.
9. Folkman J (1995). Angiogenesis in cancer, vascular, rheumatoid and other disease. Nature Med 1:27-31.
10. Fong G-H, Rossant J, Gertsenstein M, and Breitman ML (1995). Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium. Nature 376:66-70.
11. Harada K, Friedman M, Lopez JJ, Wang SY, Li J, Prasad PV, Pearlman JD, Edelman ER, Sellke FW, and Simons M (1996). Vascular endothelial growth factor administration in chronic myocardial ischemia. Am J Physiol 270:H1791-H1802.
12. Hiratsuka S, Minowa O, Kuno J, Noda T, and Shibuya M (1998). Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice. Proc Natl Acad Sci USA 95:9349-9354.
13. Inoue M, Itoh H, Ueda M, Naruko T, Kojima A, Komatsu R, Doi K, Ogawa Y, Tamura N, Takaya K, Igaki T, Yamashita J, Chun TH, Masatsugu K, Becker AE, and Nakao K (1998). Vascular endothelial growth factor (VEGF) expression in human coronary atherosclerotic lesions: Possible pathophysiological significance of VEGF in progression of atherosclerosis. Circulation 98:2108-2116.
14. Jakeman LB, Winer J, Bennett GL, Altar CA, and Ferrara N (1992). Binding sites for vascular endothelial growth factor are localized on endothelial cells in adult rat tissues. J Clin Invest 89:244-253.
15. Jehle PM, Fußgänger RD, Stracke S, Grunewald W, and Keller F (1996). Different binding and degradation of proinsulin, insulin and IGF-1 in cultured renal proximal tubular cells: implications for the prolonged serum half-life of proinsulin. Acta Diabetol 33:159-165.
16. Laitinen M and YlaHerttuala S (1998). Vascular gene transfer for the treatment of restenosis and atherosclerosis. Curr Opin Lipidol 9:465-469.
17. Li J, Brown LF, Hibberd MG, Grossman JD, Morgan JP, and Simons M (1996). VEGF, flk-1, and flt-1 expression in a rat myocardial infarction model of angiogenesis. Am J Physiol 270:1-11803-H1811.
18. Losordo DW, Vale PR, Symes JF, Dunnington CH, Esakof DD, Maysky M, Ashare AB, Lahti K, and Isner MI (1998). Gene therapy for myocardial angiogenesis. initial clinical results with direct myocardial injection of ph VEGF165 as sole therapy for myocardial ischemia. Circulation 98:2800-2804.
19. Morbidelli L, Chang C, Douglas JG, Granger HJ, Ledda F, and Ziche M (1996). Nitric oxide mediates mitogenic effect of VEGF on coronary venular endothelium. Am J Physiol 270: H411-H415.
20. Öberg C, Waltenberger J, Claesson-Welsh L, and Welsh M (1994). Expression of protein tyrosine kinases in islet cells: Possible role of the flk-1 receptor for β-cell maturation from duct cells. Growth Factors 10:115-126.
21. Pearlman JD, Hibberd MG, Chuang ML, Harada K, Lopez JJ, Gladstone SR, Friedman M, Sellke FW, and Simons M (1995). Magnetic resonance mapping demonstrates benefits of VEGF-induced myocardial angiogenesis. Nature Med 1:1085-1089.
22. Peters KG, De Vries C, and Williams LT (1993). Vascular endothelial growth factor receptor expression during embryogenesis and tissue repair suggests a role in endothelial differentiation and blood vessel growth. Proc Natl Acad Sci USA 90:8915-8919.
23. Poltorak Z, Cohen T, Sivan R, Kandelis Y, Spira G, Vlodavsky I, Keshet E, and Neufeld G (1997). VEGF(145), a secreted vascular endothelial growth factor isoform that binds to extracellular matrix. J Biol Chem 272:7151-7158.
24. Schaper W and Ito WD (1996). Molecular mechanisms of coronary collateral vessel growth. Circ Res 79:911-919.
25. Schumacher B, Pecher P, von Specht BU, and Stegmann T (1998). Induction of neoangiogenesis in ischemic myocardium by human growth factors: First clinical results of a new treatment of coronary heart disease. Circulation 97:645-650.
26. Sellke FW, Laham RJ, Edelman ER, Pearlman JD, and Simons M (1998). Therapeutic angiogenesis with basic fibroblast growth factor: Technique and early results. Ann Thorac Surg 65:1540-1544.
27. Shalaby F, Rossant J, Yamaguchi TP, Gertsenstein M, Wu X-F, Breitman ML, and Schuh AC (1995). Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice. Nature 376:62-66.
28. Shibuya M, Yamaguchi S, Yamane A, Ikeda T, Tojo A, Matsushime H, and Sato M (1990). Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase gene (fit) closely related to the fms family. Oncogene 5:519-524.
29. Shweiki D, Itin A, Soffer D, and Keshet E (1992). Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature 359:843-845.
30. Terman BI, Dougher-Vermazen M, Carrion ME, Dimitrov D, Armellino DC, Gospodarowicz D, and Böhlen P (1992). Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor. Biochem Biophys Res Commun 187:1579-1586.
31. Thomas KA (1996). Vascular endothelial growth factor, a potent and selective angiogenic agent. J Biol Chem 271:603-606.
32. Tso JY, Sun X-H, Kao T-H, Reece KS, and Wu R (1985). Isolation and characterization of rat and human glyceraldehyde-3-phosphate dehydrogenase cDNAs: genomic complexity and molecular evolution of the gene. Nucleic Acids Res 13:2485-2491.
33. Vuckovic M, Ponting J, Terman BI, Niketic V, Seif MW, and Kumar S (1996). Expression of the vascular endothelial growth factor receptor, KDR, in human placenta. J Anat 188:361-366.
34. Waltenberger J (1997). Modulation of growth factor action: Implications for the treatment of cardiovascular diseases. Circulation 96:4083-4094.
35. Waltenberger J (1998). Therapeutic angiogenesis in the heart using peptide growth factors: Angiogenesis research entering clinical trials. Angiogenesis 2:115-117.
36. Waltenberger J, Claesson-Welsh L, Siegbahn A, Shibuya M, and Heldin C-H (1994). Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor. J Biol Chem 269:26988-26995.
37. Waltenberger J, Mayr U, Pentz S, and Hombach V (1996). Functional upregulation of the vascular endothelial growth factor receptor KDR by hypoxia. Circulation 94:1647-1654.
38. Wu HM, Huang QB, Yuan Y, and Granger HJ (1996). VEGF induces NO-dependent hyperpermeability in coronary venules. Am J Physiol 40:H2735-H2739.
39. Yang R, Thomas GR, Bunting S, Ko A, Ferrara N, Keyt B, Ross J, and Jin H (1996). Effects of vascular endothelial growth factor on hemodynamics and cardiac performance. J Cardiovasc Pharmacol 27:838-844.