Molecular mechanism for the spontaneous generation of pigmentless Porphyromonas gingivalis mutants

Infection and Immunity

Volumn 67, Issue 9, 1999, Pages 4926-4930

  Chen, Wen ^a   Kuramitsu, Howard K ^a  

^a UNIVERSITY AT BUFFALO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BACTERIAL MUTATION; BACTERIAL VIRULENCE; DNA SEQUENCE; GENETIC RECOMBINATION; NONHUMAN; PORPHYROMONAS GINGIVALIS; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; STRAIN DIFFERENCE;

PORPHYROMONAS GINGIVALIS;

EID: 0032794168     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.67.9.4926-4930.1999     Document Type: Article

References (33)

1. Altschul, S. F., T. L. Madden, A. A. Schaffer, J. H. Zhang, Z. Zhang, W. Miller, and D. J. Lipman. 1997. Gapped BLAST and PSI-BLAST - a new generation of protein database search programs. Nucleic Acids Res. 25: 3389-3402.
2. Barkocy-Gallagher, G. A., N. Han, J. M. Patti, J. Whitlock, A. Progulske-Fox, and M. S. Lantz. 1996. Analysis of the prtP gene encoding porphypain, a cysteine protease of Porphyromonas gingivalis. J. Bacteriol. 178:2734-2741.
3. Calkins, C. C., K. Platt, J. Potempa, and J. Travis. 1998. Inactivation of tumor necrosis factor-alpha by proteases (gingipains) from the periodontal pathogen, Porphyromonas gingivalis. Implications of immune evasion. J. Biol. Chem. 273:6611-6614.
4. Collinson, L. M., M. Rangarajan, and M. A. Curtis. 1998. Altered expression and modification of proteases from an avirulent mutant of Porphyromonas gingivalis W50 (W50/BE1). Microbiology 144:2487-2496.
5. Fujimura, S., K. Hirai, Y. Shibata, K. Nakayama, and T. Nakamura. 1998. Comparative properties of envelope-associated arginine-gingipains and lysine-gingipain of Porphyromonas gingivalis. FEMS Microbiol. Lett. 163:173-179.
6. Genco, C. A., B. M. Odusanya, and G. Brown. 1994. Binding and accumulation of hemin in Porphyromonas gingivalis are induced by hemin. Infect. Immun. 62:2885-2892.
7. Han, N., J. Whitlock, and A. Progulske-Fox. 1996. The hemagglutinin gene A (hagA) of Porphyromonas gingivalis 381 contains four large, contiguous, direct repeats. Infect. Immun. 64:4000-4007.
8. Hinode, D., H. Hayashi, and R. Nakamura. 1991. Purification and characterization of three types of proteases from culture supernatants of Porphyromonas gingivalis. Infect. Immun. 59:3060-3068.
9. Imamura, T., J. Potempa, R. N. Pike, and J. Travis. 1995. Dependence of vascular permeability enhancement on cysteine proteases in vesicles of Porphyromonas gingivalis. Infect. Immun. 63:1999-2003.
10. Kadowaki, T., K. Nakayama, F. Yoshimura, K. Okamoto, N. Abe, and K. Yamamoto. 1998. Arg-gingipain acts as a major processing enzyme for various cell surface proteins in Porphyromonas gingivalis. J. Biol. Chem. 273: 29072-29076.
11. Kozarov, E., J. Whitlock, H. Dong, E. Carrasco, and A. Progulske-Fox. 1998. The number of direct repeats in hagA is variable among Porphyromonas gingivalis strains. Infect. Immun. 66:4721-4725.
12. Kuboniwa, M., A. Amano, and S. Shizukuishi. 1998. Hemoglobin-binding protein purified from Porphyromonas gingivalis is identical to lysine-specific cysteine protease (Lys-gingipain). Biochem. Biophys. Res. Commun. 249: 38-43.
13. Kuramitsu, H. K. 1998. Proteases of Porphyromonas gingivalis: what don't they do? Oral Microbiol. Immunol. 13:263-270.
14. Lewis, J. P., and F. L. Macrina. 1998. IS195, an insertion sequence-like element associated with protease genes in Porphyromonas gingivalis. Infect. Immun. 66:3035-3042.
15. McKee, A. S., A. S. McDermid, R. Wait, A. Baskerville, and P. D. Marsh. 1988. Isolation of colonial variants of Bacteroides gingivalis W50 with a reduced virulence. J. Med. Microbiol. 27:59-64.
16. Nakayama, K., T. Kadowaki, K. Okamoto, and K. Yamamoto. 1995. Construction and characterization of arginine-specific cysteine protease (Arg-gingipain)-deficient mutants of Porphyromonas gingivalis. J. Biol. Chem. 270: 23619-23626.
17. Nakayama, K., D. B. Ratnayake, T. Tsukuba, T. Kadowaki, K. Yamamoto, and S. Fujimura. 1998. Haemoglobin receptor protein is intragenically encoded by the cysteine protease-encoding genes and the haemagglutinin-encoding gene of Porphyromonas gingivalis. Mol. Microbiol. 27:51-61.
18. Okamoto, K., T. Kadowaki, K. Nakayama, and K. Yamamoto. 1996. Cloning and sequencing of the gene encoding a novel lysine-specific cysteine protease (Lys-gingipain) in Porphyromonas gingivalis: structural relationship with the arginine-specific cysteine protease (Arg-gingipain). J. Biochem. 120:398-406.
19. Okamoto, K., K. Nakayama, T. Kadowaki, N. Abe, D. B. Ratnayake, and K. Yamamoto. 1998. Involvement of a lysine-specific cysteine protease in hemoglobin adsorption and heme accumulation by Porphyromonas gingivalis. J. Biol. Chem. 273:21225-21231.
20. Otogoto, J. I., and H. K. Kuramitsu. 1993. Isolation and characterization of the Poiphyromonas gingivalis prtT gene, coding for protease activity. Infect. Immun. 61:117-123.
21. Pavloff, N., P. A. Pemberton, J. Potempa, W. C. Chen, R. N. Pike, V. Prochazka, M. C. Kiefer, J. Travis, and P. J. Barr. 1997. Molecular cloning and characterization of Porphyromonas gingivalis lysine-specific gingipain. A new member of an emerging family of pathogenic bacterial cysteine proteases. J. Biol. Chem. 272:1595-1600.
22. Pike, R., W. McGraw, J. Potempa, and J. Travis. 1994. Lysine- and arginine-specific proteases from Porphyromonas gingivalis. J. Biol. Chem. 269:406-411.
23. Pike, R. N., J. Potempa, W. McGraw, T. H. Coetzer, and J. Travis. 1996. Characterization of the binding activities of protease-adhesin complexes from Porphyromonas gingivalis. J. Bacteriol. 178:2876-2882.
24. Potempa, J., R. Pike, and J. Travis. 1995. The multiple forms of trypsin-like activity present in various strains of Porphyromonas gingivalis are due to the presence of either Arg-gingipain or Lys-gingipain. Infect. Immun. 63:1176-1182.
25. Scott, C. F., E. J. Whitaker, B. F. Hammond, and R. W. Colman. 1993. Purification and characterization of a potent 70-kDa thiol lysyl-protease (Lys-gingivain) from Porphyromonas gingivalis that cleaves kininogens and fibrinogen. J. Biol. Chem. 268:7935-7942.
26. Shah, H. N., R. Bonnett, B. Matten, and A. D. Williams. 1979. The porphyrin pigmentation of subspecies of Bacteroides melaninogenicus. Biochem. J. 180:45-50.
27. Slots, J., and H. S. Reynolds. 1982. Long-wave UV light fluorescence for identification of black-pigmented Bacteroides spp. J. Clin. Microbiol. 16: 1148-1151.
28. Smalley, J. W., A. J. Birss, A. S. Mckee, and P. D. Marsh. 1998. Hemin regulation of hemoglobin binding by Porphyromonas gingivalis. Curr. Microbiol. 36:102-106.
29. The Institute for Genomic Research Website. 1999, copyright date. [Online.] The Institute for Genomic Research, http://www.tigr.org. [20 December 1998, last date accessed.]
30. Tokuda, M., W. Chen, T. Karunakaran, and H. K. Kuramitsu. 1998. Regulation of protease expression in Porphyromonas gingivalis. Infect. Immun. 66:5232-5237.
31. Tokuda, M., M. Duncan, M.-I. Cho, and H. K. Kuramitsu. 1996. Role of Porphyromonas gingivalis protease activity in colonization of oral surfaces. Infect. Immun. 64:4067-4073.
32. Tokuda, M., T. Karunakaran, M. Duncan, N. Hanada, and H. K. Kuramitsu. 1998. Role of Arg-gingipain A in virulence of Porphyromonas gingivalis. Infect. Immun. 66:1159-1166.
33. Yoneda, M., and H. K. Kuramitsu. 1996. Genetic evidence of the relationship of Porphyromonas gingivalis cysteine protease and hemagglutinin activities. Oral Microbiol. Immunol. 11:129-134.