In vivo and in vitro pharmacokinetics and metabolism studies of 26,26,26,27,27,27-F6-1,25(OH)2 vitamin D3 (Falecalcitriol) in rat: Induction of vitamin D3-24-hydroxylase (CYP24) responsible for 23S-hydroxylation in target tissues and the drop in serum levels

Xenobiotica

Volumn 29, Issue 6, 1999, Pages 603-613

  Komuro, S ^a   Sato, M ^a   Kanamaru, H ^a   Kaneko, H ^a   Nakatsuka, I ^b   Yoshitake, A ^c  

^a SUMITOMO CHEMICAL CO LTD   (Japan)

^b DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

^c KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

FALECALCITRIOL; OXYGENASE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG HYDROXYLATION; DRUG METABOLISM; ENZYME INDUCTION; ENZYME SUBSTRATE; ISOTOPE LABELING; KIDNEY; MALE; NONHUMAN; NORTHERN BLOTTING; PHARMACOKINETICS; RAT; SMALL INTESTINE; VITAMIN BLOOD LEVEL; VITAMIN D METABOLISM; VITAMIN METABOLISM;

ADMINISTRATION, ORAL; ANIMALS; BLOTTING, NORTHERN; CALCITRIOL; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INDUCTION; HYDROXYLATION; INTESTINE, SMALL; LIVER; MALE; RATS; RATS, WISTAR; RNA, MESSENGER; STEROID HYDROXYLASES; TISSUE DISTRIBUTION;

ANIMALIA;

EID: 0032791982     PISSN: 00498254     EISSN: None     Source Type: Journal    
DOI: 10.1080/004982599238425     Document Type: Article

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