The prooligonucleotide approach: Synthesis of mixed sate-phosphotriester phosphodiester oligonucleotides

Nucleosides and Nucleotides

Volumn 18, Issue 6-7, 1999, Pages 1433-1434

  Bologna, J C ^a   Tosquellas, G ^a   Morvan, F ^a   Rayner, B ^a   Imbach, J L ^a  

^a UNIVERSITÉ DE MONTPELLIER   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ESTER DERIVATIVE; OLIGONUCLEOTIDE; PHOSPHORUS DERIVATIVE;

CHEMICAL STRUCTURE; CONFERENCE PAPER; HYDROLYSIS; LIPOPHILICITY; OXIDATION; PHOTOLYSIS; SYNTHESIS;

EID: 0032791301     PISSN: 07328311     EISSN: None     Source Type: Journal    
DOI: 10.1080/07328319908044744     Document Type: Conference Paper

References (3)

1. Tosquellas, G.; Alvarez, K.; Dell'Aquila, C.; Morvan, F.; Vasseur, J. J.; Imbach, J. L.; Rayner, B. Nucleic Acids Res. 1998, 26, 2069-2074.
2. Tosquellas, G.; Bologna, J. C.; Morvan, F.; Rayner, B.; Imbach, J. L. Bioorg. Med. Chem. Lett. 1998, 8, 2913-2918.
3. A 3′-desulfurization and dimerization for prooligos bearing a 3′-phosphorothioate monoester occurred during the release of the prooligo from the solid support due to the formation of a nitroso function during the photolysis. This side reaction could be avoid by addition of DTT.