Synthesis and properties of some morpholino oligonucleotide analogues

Nucleosides and Nucleotides

Volumn 18, Issue 6-7, 1999, Pages 1427-1428

  Chakhmakhcheva, O ^a   Andrianov, M ^a   Buryakova, A ^a   Choob, M ^a   Efimov, V ^a  

^a SHEMYAKIN OVCHINNIKOV INSTITUTE OF BIOORGANIC CHEMISTRY   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

MORPHOLINE DERIVATIVE; OLIGONUCLEOTIDE;

CHEMICAL REACTION; COMPLEX FORMATION; CONFERENCE PAPER; DRUG STRUCTURE; DRUG SYNTHESIS; HYBRIDIZATION; REACTION ANALYSIS;

EID: 0032791299     PISSN: 07328311     EISSN: None     Source Type: Journal    
DOI: 10.1080/07328319908044742     Document Type: Conference Paper

References (5)

1. Summerton, J.; Weller, D. Antisense Nucleic Acid Drug Dev., 1997. 7, 187-195.
2. Efimov, V.; Choob, M.; Kalinkina, A.; Chakhmakhcheva, O. Nucleosides & Nucleotides, 1997, 16, 1475-1480.
3. Efimov, V.; Buryakova, A.; Chakhmakhcheva, O. Bio. Med. Lett., 1998, 8, 1013-1018.
4. 2, 3.
5. Efimov, V.; Buryakova, A.; Reverdatto, S.; Chakhmakhcheva, O.; Ovchinnikov, Yu. Nucleic Acids Res., 1983, 11, 8369-8387. The condensations during the chain elongation were performed for 10 min in acetonitrile - pyridine (2:1, v/v) using monomers (7) (0.05 M), TPSCl (0.15 M) and MeIm (0.3 M). The target oligomer was cleaved from the support by the action of tert-butylamine - dioxane (1:1, v/v) for 2 hrs at 20°C.