HEK-293 cells expressing the human dopamine transporter are susceptible to low concentrations of 1-methyl-4-phenylpyridine (MPP+) via impairment of energy metabolism

Neurochemistry International

Volumn 35, Issue 5, 1999, Pages 393-403

  Storch, Alexander ^a   Ludolph, Albert C ^a   Schwarz, Johannes ^a  

^a UNIVERSITY OF ULM MEDICAL SCHOOL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; DOPAMINE TRANSPORTER;

ARTICLE; CELL VIABILITY; CONTROLLED STUDY; EMBRYO CELL; ENERGY METABOLISM; GENETIC TRANSFECTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; KIDNEY CELL; MITOCHONDRIAL RESPIRATION; NEUROTOXICITY; PARKINSON DISEASE; PRIORITY JOURNAL;

1-METHYL-4-PHENYLPYRIDINIUM; ANTIOXIDANTS; CARRIER PROTEINS; CELL LINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; ENERGY METABOLISM; HUMANS; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; NERVE TISSUE PROTEINS; TRANSFECTION;

EID: 0032790412     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0197-0186(99)00083-2     Document Type: Article

References (55)

1. + neurotoxicity against rat dopaminergic neurons in culture. Neurosci. Lett. 193:1995;53-56.
2. + toxicity in rat striatal slices: relationship between non-selective effects and free radical production. Neurochem. Res. 21:1996;73-78.
3. Bates T.E., Heales S.J.R., Davies S.E.C., Boakye P., Clark J.B. Effects of 1-methyl-4-phenylpyridinium on isolated rat brain mitochondria: evidence for primary involvement of energy depletion. J. Neurochem. 63:1994;640-648.
4. Bradford M.M. A rapid and sensitive method for the quantification of microgram quantities of protein utilising the principle of protein-dye binding. Anal. Biochem. 72:1976;248-254.
5. Brown G.C. Control of respiration and ATP synthesis in mammalian mitochondria and cells. Biochem. J. 284:1992;1-13.
6. Buckman T.D., Chang R., Sutphin M.S., Eiduson S. Interaction of 1-methyl-4-phenylpyridinium ion with human platelets. Biochem. Biophys. Res. Commun. 151:1988;897-904.
7. Burns R.S., Chuang C.C., Markey S.P., Ebert M.H., Kopin I.J. A primate model of Parkinsonism: selective destruction of dopaminergic neurons in pars compacta of substantia nigra by n-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Proc. Natl. Acad. USA. 80:1983;4546-4550.
8. Chen C., Okayama H. High efficiency transformation of mammalian cells by plasmid DNA. Mol. Cell. Biol. 7:1987;2745-2752.
9. 50) of an enzymatic reaction. Biochem. Pharmacol. 22:1973;3099-3108.
10. +. Free Radic. Biol. Med. 13:1992;581-583.
11. Denton T., Howard B.D. A dopaminergic cell line variant resistant to the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. J. Neurochem. 49:1987;622-630.
12. +) cytotoxicity. Biochem. Biophys. Res. Commun. 137:1986;303-309.
13. +) cause rapid ATP depletion in isolated hepatocytes. Biochem. Biophys. Res. Commun. 137:1986;310-315.
14. Di Monte D., Wu E.Y., DeLanney L.E., Irwin I., Langston J.W. Toxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in primary cultures of mouse astrocytes. J. Pharmacol. Exp. Ther. 261:1992;44-49.
15. Dodel R., Du Y., Bales K.R., Ling Z.D., Carvey P.M., Paul S.M. Peptide inhibitors of caspases-3-like proteases attenuate 1-methyl-4-phenylpyridinum-induced toxicity of cultured fetal rat mesencephalic dopamine neurons. Neurosci. 86:1998;701-707.
16. Forno L.S., Langston J.W., DeLanney L.E., Irwin I., Ricaurte A. Locus coeruleus lesions and eosinophilic inclusions in MPTP-treated monkeys. Ann. Neurol. 20:1986;449-455.
17. Fukushima T., Tawara T., Iobe A., Hojo N., Shiwaku K., Yamane Y. Radical formation site of cerebral complex I and Parkinson's disease. J. Neurosci. Res. 42:1995;385-390.
18. Gainetdinov R.R., Fumagalli F., Jones S.R., Caron M.G. Dopamine transporter is required for in vivo MPTP neurotoxicity: evidence from mice lacking the transporter. J. Neurochem. 69:1997;1322-1325.
19. Gerlach M., Riederer P., Przuntek H., Youdim M.B.H. MPTP mechanisms of neurotoxicity and their implications for Parkinson's disease. Eur. J. Pharmacol. 208:1991;273-286.
20. Heikkila R.E., Manzino L., Cabbat F.S., Duvoisin R.C. Studies in the oxidation of the dopaminergic neurotoxin MPTP by monoamine oxidase B. J. Neurochem. 45:1985;1049-1054.
21. +) causes DNA fragmentation and increases the Bcl-2 expression in the human neuroblastoma, SH-SY5Y cells, through different mechanisms. Brain Res. 704:1995;240-245.
22. Javitch J.A., D'Amato R.J., Strittmatter S.M., Snyder S.H. Parkinsonism-inducing neurotoxin, n-methyl-4-phenyl-1,2,3,6-tetrahydropyridine: uptake of the metabolite n-methyl-4-phenylpyridine by dopamine neurons explain selective toxicity. Proc. Natl. Acad. Sci. USA. 82:1985;2173-2177.
23. +: uptake and toxicity in non-neuronal COS cells expressing dopamine transporter cDNA. Ann. Neurol. 32:1992;109-111.
24. + toxicity and plasma membrane dopamine transporter: study using cell lines expressing the wild-type and mutant rat dopamine transporters. Biochim. Biophys. Acta. 1404:1998;305-313.
25. Krige D., Carroll M.T., Cooper J.M., Marsden C.D., Schapira A.H. Platelet mitochondrial function in Parkinson's disease: the Royal Kings and Queens Parkinson's disease research group. Ann. Neurol. 32:1992;782-788.
26. Kutty R.K., Santostasi G., Horng J., Krishna G. MPTP-induced ATP depletion and cell death in neuroblastoma×glioma hybrid NG 108-15 cells: protection by glucose and sensitisation by tetraphenylborate. Toxicol. Appl. Pharmacol. 107:1991;377-388.
27. Langston J.W., Ballard P., Tetrud J.W., Irwin I. Chronic parkinsonism in humans due to a product of meperidine-analog synthesis. Science. 219:1983;979-980.
28. Marini A.M., Schwartz J.P., Kopin I.J. The neurotoxicity of 1-methyl-4-phenylpyridinium in cultured cerebellar granule cells. J. Neurosci. 9:1989;3665-3672.
29. Mayer R.A., Kindt N.V., Heikkila R.E. Prevention of nigrostriatal toxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by inhibitors of 3,4-dihydroxyphenylethylamine transport. J. Neurochem. 47:1986;1073-1079.
30. Michel P.P., Dandapani B.K., Knusel B., Sanchez-Ramos J., Hefti F. Toxicity of 1-methyl-4-phenylpyridinium for rat dopaminergic neurons in culture: selectivity and irreversibility. J. Neurochem. 54:1990;1102-1109.
31. Mihatsch W., Russ H., Gerlach M., Riederer P., Przuntek H. Treatment with antioxidants does not prevent loss of dopamine in the striatum of MPTP-treated common marmosets: preliminary observations. J. Neural. Transm. Park. Dis. Dement. Sect. 3:1991;73-78.
32. Mizuno Y., Sone N., Saitoh T. Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 1-methyl-4-phenylpyridium ion on activities of the enzymes in the electron transport system in mouse brain. J. Neurochem. 48:1987;1787-1793.
33. +) in isolated mitochondria from mouse brain. Neurosci. Lett. 81:1987;204-208.
34. Mizuno Y., Ohta S., Tanaka M., Takamiya S., Suzuki K., Sato T., Oya H., Ozawa T., Kagawa Y. Deficiencies in complex I subunits of the respiratory chain in Parkinson's disease. Biochem. Biophys. Res. Commun. 163:1989;1450-1455.
35. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods. 65:1983;55-63.
36. Mytilineou C., Friedman L. Studies on the metabolism and toxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in cultures of embryonic rat mesencephalon. J. Neurochem. 51:1988;750-755.
37. Mytilineou C., Werner P., Molinari S., Di Rocco A., Cohen G., Yahr M.D. Impaired oxidative decarboxylation of pyruvate in fibroblasts from patients with Parkinson's disease. J. Neural. Transm. 8:1994;223-228.
38. Nicklas W.J., Vyas I., Heikkila R.E. Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenylpyridine, a metabolite of the neurotoxin, 1-methyl-1,2,3,6-tetrahydropyridine. Life Sci. 36:1985;2503-2508.
39. +). J. Electroanal. Chem. 242:1988;171-179.
40. Pastorino J.G., Snyder J.W., Hoek J.B., Farber J.L. Ca2+ depletion prevents anoxic death of hepatocytes by inhibiting mitochondrial permeability transition. Am. J. Physiol. 268:1995;C676-C685.
41. Perry T.L., Yong V.W., Clavier R.M., Jones K., Wright J.M., Foulks J.G., Wall R.A. Partial protection from the dopaminergic neurotoxin n-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by different antioxidants in the mouse. Neurosci. Lett. 60:1985;109-114.
42. Pifl C., Giros B., Caron M.G. Dopamine transporter expression confers cytotoxicity to low doses of the Parkinsonism-inducing neurotoxin 1-methyl-4-phenylpyridinium. J. Neurosci. 13:1993;4246-4253.
43. Ramsay R.R., Singer T.P. Energy-dependent uptake of n-methyl-4-phenylpyridinium, the neurotoxic metabolite of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, by mitochondria. J. Biol. Chem. 261:1986;7585-7587.
44. +. Biochem. Biophys. Res. Commun. 189:1992;47-52.
45. Riepe M.W., Schmalzigaug K., Fink F., Oexle K., Ludolph A.C. NADH in the pyramidal cell layer of hippocampal regions CA1 and CA3 upon selective inhibition and uncoupling of oxidative phosporylation. Brain Res. 710:1996;21-27.
46. Rossetti Z.L., Sotgiu A., Sharp D.E., Hadjiconstantinou M., Neff N.H. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and free radicals in vitro. Biochem. Pharmacol. 37:1988;4573-4574.
47. Schapira A.H.V., Cooper J.M., Dexter D., Clark J.B., Jenner P., Marsden C.D. Mitochondrial complex I deficiency in Parkinson's disease. J. Neurochem. 54:1990;823-827.
48. + induced apoptotic cell death in SH-SY5Y neuroblastoma cells: an electron microscopy study. J. Neurosci. Res. 48:1997;226-237.
49. Siess E.A., Wieland O.H. Phosphorylation state of cytosolic and mitochondrial adenine nucleotides and of pyruvate dehydrogenase in isolated rat liver cells. Biochem J. 156:1976;91-102.
50. Snyder J.W., Pastorino J.G., Attie A.M., Farber J.L. Protection by cyclosporin A of cultured hepatocytes from the toxic consequences of the loss of mitochondrial energization produced by 1-methyl-4-phenylpyridinium. Biochem. Pharmacol. 44:1992;833-835.
51. Spina M.B., Squinto S.P., Miller J., Lindsay R.M., Hyman C. Brain-derived neurotrophic factor protects dopamine neurons against 6-hydroxydopamine and n-methyl-4-phenylpyridinium ion toxicity: involvement of the glutathione system. J. Neurochem. 59:1992;99-106.
52. Stocchi V., Cucchiarini L., Magnani M., Chiarantini L., Palma P., Crescentini G. Simultaneous extraction and reverse-phase high-performance liquid chromatographic determination of adenine and pyridine nucleotides in human blood cells. Anal. Biochem. 146:1985;118-124.
53. Tsai M.J., Lee E.H. Nitric oxide donors protect cultured rat astrocytes from 1-methyl-4-phenylpyridiunium-induced toxicity. Free Radic. Biol. Med. 24:1998;705-713.
54. Wu E.Y., Smith M.T., Bellomo G., Di Monte D. Relationships between the mitochondrial transmembrane potential, ATP concentration, and cytotoxicity in isolated rat hepatocytes. Arch. Biochem. Biophys. 282:1990;358-362.
55. Wynants J., Van Belle H. Single-run high-performance chromatography of nucleotides, nucleosides, and major purine bases and its application to different tissue extracts. Anal. Biochem. 144:1985;258-266.