Double-blind study of the addition of high-protein soya milk v. cows' milk to the diet of patients with severe hypercholesterolaemia and resistance to or intolerance of statins

British Journal of Nutrition

Volumn 82, Issue 2, 1999, Pages 91-96

  Sirtori, Cesare R ^c   Pazzucconi, F ^c   Colombo, L ^a   Battistin, P ^c   Bondioli, A ^c   Descheemaeker, K ^b  

^a SAN PAOLO HOSPITAL   (Italy)

^b Alpro NV   (Belgium)

^c NONE

Author keywords

Cows' milk; Hypercholesterolaemia; Soyabean protein

Indexed keywords

CHOLESTEROL; LIPID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; STATIN;

ADULT; AGED; ARTICLE; BEVERAGE; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; COW; DIET SUPPLEMENTATION; DOUBLE BLIND PROCEDURE; HUMAN; HYPERCHOLESTEROLEMIA; LIPID BLOOD LEVEL; MILK; RANDOMIZED CONTROLLED TRIAL; SOYBEAN; TREATMENT FAILURE;

ANIMALIA; GLYCINE MAX;

EID: 0032788115     PISSN: 00071145     EISSN: None     Source Type: Journal    
DOI: 10.1017/s0007114599001233     Document Type: Article

References (36)

1. Anderson JW, Johnstone BJ & Cook-Newell ME (1995) Meta-analysis of the effects of soy protein intake on serum lipids. New England Journal of Medicine 333, 276-282.
2. Anderson JW, Story L, Sieling B, Lin Chen W-J, Petro MS & Story J (1984) Hypocholesterolemic effects of oat-bran or bean intake for hypercholesterolemic men. American Journal of Clinical Nutrition 40, 1146-1155.
3. Anthony MS, Clarkson TB, Hughes CL, Morgan TM & Burke GL (1996) Soybean isoflavones improve cardiovascular risk factors without affecting the reproductive system of prepubertal rhesus monkeys. Journal of Nutrition 126, 43-50.
4. Bakhit RM, Klein BP, Essex-Sorlie D, Ham JO, Erdman JW Jr & Potter SM (1994) Intake of 25 g of soybean protein with or without soybean fiber alters plasma lipids in men with elevated cholesterol concentrations. Journal of Nutrition 124, 213-222.
5. Calvert GD, Blight L, Illman RJ, Topping DL & Potter JD (1981) A trial of the effects of soya-bean flour and soya-bean saponins on plasma lipids, faecal bile acids and neutral sterols in hypercholesterolaemic men. British Journal of Nutrition 45, 277-281.
6. Carroll KK (1991) Review of clinical studies on cholesterol-lowering response to soy protein. Journal of the American Dietetic Association 91, 820-827.
7. Cassidy A, Bingham S & Setchell KDR (1994) Biological effects of a diet of soy protein rich in isoflavones on the menstrual cycle of premenopausal women. American Journal of Clinical Nutrition 60, 333-340.
8. Finkel E (1998) Phyto-oestrogens: the way to postmenopausal health? (editorial). Lancet 352, 1762.
9. Friedewald WT, Levy RI & Fredrickson DS (1972) Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clinical Chemistry 18, 499-502.
10. Frühbeck G, Monreal I & Santidrian S (1997) Hormonal implications of the hypocholesterolemic effects of field beans (Vicia faba L.) by young men with hypercholesterolemia. American Journal of Clinical Nutrition 66, 1452-1460.
11. Fumagalli R, Soleri L, Musanti R, Mantero O, Noseda C, Gatti E & Sirtori CR (1982) Fecal cholesterol excretion studies in type II hypercholesterolemic patients treated with the soybean protein diet. Atherosclerosis 43, 341-353.
12. Giroux I, Lavigne C, Moorjani S & Jacques H (1997) Simvastatin further enhances the hypocholesterolemic effect of soy protein in rabbits. Journal of the American College of Nutrition 16, 166-174.
13. Grove RI, Mazzucco CR, Radka SF, Shoyab M & Kiener PA (1991) Oncostatin M up-regulates low density lipoprotein receptors in HepG2 cells by a novel mechanism. Journal of Biological Chemistry 266, 18194-18199.
14. Hodgson JM, Pudey IB, Beilin LJ, Mori TA & Croft KD (1998) Supplementation with isoflavonoid phytoestrogens does not alter serum lipid concentrations: a randomized controlled trial in humans. Journal of Nutrition 128, 728-732.
15. Kurowska EM, Jordan J, Spence JD, Wetmore S, Piché LA, Radzikowski M, Dandona P & Carroll KK (1997) Effects of substituting dietary soybean protein and oil for milk protein and fat in subjects with hypercholesterolemia. Clinical Investigation in Medicine 20, 162-170.
16. Ladas SD, Katsiyiannaki-Latoufi E & Raptis SA (1991) Lactose maldigestion and milk intolerance in healthy Greek school-children. American Journal of Clinical Nutrition 53, 676-680.
17. Lopez-Miranda J, Ordovas JM, Mata P, Lichtenstein AH, Clevidence B, Judd JT & Schaefer EJ (1994) Effect of apolipoprotein E phenotype on diet-induced lowering of plasma low density lipoprotein cholesterol. Journal of Lipid Research 35, 1965-1975.
18. Lovati MR, Manzoni C, Canavesi A, Sirtori M, Vaccarino V, Marchi M, Gaddi G & Sirtori CR (1987) Soybean protein diet increases low density lipoprotein receptor activity in mononuclear cells from hypercholesterolemic patients. Journal of Clinical Investigation 80, 125-130.
19. Nestel PJ, Yamashita T, Sasahara T, Pomeroy S, Dart A, Komesaroff P, Owen A & Abbey M (1997) Soy isoflavones improve systemic arterial compliance but not plasma lipids in menopausal and perimenopausal women. Arteriosclerosis Thrombosis and Vascular Biology 17, 3392-3398.
20. Ni W, Tsuda Y, Sakono M & Imaizumi K (1998) Dietary soy protein isolate, compared with casein, reduces atherosclerotic lesion area in apolipoprotein E-deficient mice. Journal of Nutrition 128, 1884-1889.
21. Noseda G, Fragiacomo C, Gatti E, Descovich GC & Sirtori CR (1982) Glucagon release following experimental diets in man: effects of soybean and casein enriched diets. Pharmacological Research Communications 257, 867-877.
22. Pazzucconi F, Dorigotti F, Gianfranceschi G, Campagnoli G, Sirtori M, Franceschini G & Sirtori CR (1995) Therapy with HMG CoA reductase inhibitors: characteristics of the long-term permanence of hypocholesterolemic activity. Atherosclerosis 117, 189-198.
23. Potter SM (1998) Soy protein and cardiovascular disease: the impact of bioactive components in soy. Nutrition Reviews 56, 231-235.
24. Rubinstein A & Weintraub M (1995) Escape phenomenon of low-density lipoprotein cholesterol during lovastatin treatment. American Journal of Cardiology 76, 184-186.
25. Simons LA, Nestel PJ, Clifton P, Janus ED, Simons J & Parfitt A (1992) Treatment of primary hypercholesterolaemia with pravastatin: efficacy and safety over three years. Medical Journal of Australia 157, 584-589.
26. Sirtori CR (1993) Tissue selectivity of hydroxymethylglutaryl coenzyme A (HMG CoA) reductase inhibitors. Pharmacology and Therapeutics 60, 431-459.
27. Sirtori CR, Agradi E, Sirtori M, Conti F & Paoletti R (1977) Soybean-protein diet in the treatment of type II hyperlipoproteinaemia. Lancet i, 275-278.
28. Sirtori CR, Gatti E, Mantero O, Conti F, Agradi E, Tremoli E, Sirtori M, Fraterrigo L, Tavazzi L & Kritchevsky D (1979) Clinical experience with the soybean protein diet in the treatment of hypercholesterolemia. American Journal of Clinical Nutrition 32, 1645-1658.
29. Sirtori CR, Gianazza E, Manzoni C, Lovati MR & Murphy PA (1997) Role of isoflavones in the cholesterol reduction by soy proteins in the clinic. American Journal of Clinical Nutrition 65, 166-167.
30. Sirtori CR, Lovati MR, Manzoni C, Gianazza E, Bondioli A, Staels B & Auwerx J (1999) Reduction of serum cholesterol by soy proteins. Nutrition Metabolism Cardiovascular Disease 8, 334-340.
31. Sirtori CR, Lovati MR, Manzoni C, Monetti M, Pazzucconi F & Gatti E (1995) Soy and cholesterol reduction: clinical experience. Journal of Nutrition 125, 598S-605S.
32. Sirtori CR, Tremoli E, Gatti E, Montanari G, Sirtori M, Colli S, Gianfranceschi G, Maderna P, Zucchi Dentone C, Testolin G & Galli C (1986) Controlled evaluation of fat intake in the Mediterranean diet: comparative activities of olive oil and corn oil on plasma lipids and platelets in high-risk patients. American Journal of Clinical Nutrition 44, 635-642.
33. Tovar-Palacios C, Potter SM, Hafermann JC & Shay NF (1998) Intake of soy protein and soy protein extracts influences lipid metabolism and hepatic gene expression in gerbils. Journal of Nutrition 128, 839-842.
34. Wallenstein S & Fisher AC (1977) The analysis of the two-period repeated measurements cross-over design with application to clinical trials. Biometrics 33, 261-269.
35. 2+ precipitation procedure for quantitation of high-density lipoprotein. Clinical Chemistry 28, 1379-1388.
36. Wilson TA, Behr SR & Nicolosi RJ (1998) Addition of guar gum and soy protein increases the efficacy of the American Heart Association (AHA) step I cholesterol-lowering diet without reducing high density lipoprotein cholesterol levels in non-human primates. Journal of Nutrition 128, 1429-1433.