Oral bioavailability and pharmacokinetics of trovafloxacin in patients with AIDS

Antimicrobial Agents and Chemotherapy

Volumn 43, Issue 12, 1999, Pages 3005-3007

  Lacy, Melinda K ^a   Nicolau, David P ^b   Nightingale, Charles H ^b   Geffken, Amy ^c   Teng, Renli ^c   Vincent, John ^c   Quintiliani, Richard ^b  

^a UNIVERSITY OF KANSAS MEDICAL CENTER   (United States)

^b HARTFORD HOSPITAL   (United States)

^c PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALATROFLOXACIN; TROVAFLOXACIN;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG DETERMINATION; DRUG SCREENING; FEMALE; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; MALE; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

EID: 0032786997     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/aac.43.12.3005     Document Type: Article

References (27)

1. Bartlett, J. G., P. C. Belitsos, and C. L. Sears. 1992. AIDS enteropathy. Clin. Infect. Dis. 15:726-735.
2. Berning, S. E., G. A. Huitt, M. D. Iseman, and C. A. Peloquin. 1492. Malabsorption of antituberculosis medications by a patient with AIDS. N. Engl. J. Med. 327:1817-1818. (Letter.)
3. Centers for Disease Control and Prevention. 1992. 1993 revised CDC HIV classification system and expanded AIDS surveillance definition for adolescents and adults. Morbid. Mortal. Weekly Rep. 41:1-19.
4. Chien, S. C., A. T. Chow, M. C. Rogge, R. R. Williams, and C. W. Hendrix. 1997. Pharmacokinetics and safety of oral levofloxacin in human immunodeficiency virus-infected individuals receiving concomitant zidovudine. Antimicrob. Agents Chemother. 41:1765-1769.
5. Chin, T. W. F., A. Vandenbroucke, and I. W. Fong. 1995. Pharmacokinetics of trimethoprim-sulfamethoxazole in critically ill and non-critically ill AIDS patients. Antimicrob. Agents Chemother. 39:28-33.
6. DeMuria, D., A. Forrest, J. Rich, J. M. Scavone, L. G. Cohen, and P. H. Kazanjian. 1993. Pharmacokinetics and bioavailability of fluconazole in patients with AIDS. Antimicrob. Agents Chemother. 37:2187-2192.
7. Ehrenpreis, E. D., S. P. Gulino, B. K. Patterson, R. M. Craig, H. Yokoo, and A. J. Atkinson. 1991. Kinetics of D-xylose absorption in patients with human immunodeficiency virus enteropathy. Clin. Pharmacol. Ther. 49:632-640.
8. Gatti, G., J. Flaherty, J. Bubp, J. While, M. Borin, and J. Gambertoglio. 1993. Comparative study of bioavailabilities and pharmacokinetics of clindamycin in healthy volunteers and patients with AIDS. Antimicrob. Agents Chemother. 37:1137-1143.
9. Gillin, J. S., M. Shike, N. Alcock, C. Urmacher, S. Krown, R. C. Kurtz, C. J. Lightdale, and S. J. Winawer. 1985. Malabsorption and mucosal abnormalities of the small intestine in the acquired immunodeficiency syndrome. Ann. Intern. Med. 102:610-622.
10. Goodwin, S. D., H. A. Gallis, A. T. Chow, F. A. Wong, S. C. Flor, and J. A. Bartlett. 1994. Pharmacokinetics and safety of levofloxacin in patients with human immunodeficiency virus infection. Antimicrob. Agents Chemother. 38:799-804.
11. Guarino, A., F. Albano, A. Castaldo, M. I. Spagnuolo, and R. B. Canani. 1998. Intestinal malabsorption and zidovudine bioavailability. J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 18:91-92. (Letter.)
12. Kapembwa, M. S., S. C. Fleming, M. Orr, C. Wells, M. Bland, D. Back, and G. E. Griffin. 1996. Impaired absorption of zidovudine in patients with AIDS-related small intestinal disease. AIDS 10:1509-1514.
13. Klepser, M. E., Z. Zhu, D. P. Nicolau, M. A. Banevicius, J. W. Ross, L. Broisman, P. P. Belliveau, R. Quintiliani, and C. H. Nightingale. 1996. Oral absorption of trimethoprim/sulfamethoxazole in patients with AIDS. Pharmacotherapy 16:656-662.
14. Kotler, D. P., A. Francisco, and F. Clayton. 1990. Small intestinal injury and parasitic disease in AIDS. Ann. Intern. Med. 113:444-449.
15. Lacy, M., D. Nicolau, C. Nightingale, A. Geffken, R. Teng, J. Vincent, and R. Quintiliani. 1997. The pharmacokinetics of trovafloxacin in patients with AIDS, abstr. A-64, p. 13. In Abstracts of the 37th Interscience Conference on Antimicrobial Agents and Chemotherapy. American Society for Microbiology, Washington, D.C.
16. Macnab, K. A., M. J. Gill, L. R. Sutherland, N. De Boer Visser, and D. Church. 1993. Erratic zidovudine bioavailability in HIV seropositive patients. J. Antimicrob. Chemother. 31:421-428.
17. Owens, R. C., Jr., K. B. Patel, M. A. Banevicius, R. Quintiliani, C. H. Nightingale, and D. P. Nicolau. 1997. Oral bioavailability and pharmacokinetics of ciprofloxacin in patients with AIDS. Antimicrob. Agents Chemother. 41:1508-1511.
18. Patel, K. B., R. Belmonte, and H. M. Crowe. 1995. Drug malabsorption and resistant tuberculosis in HIV-infected patients. N. Engl. J. Med. 332:336-337. (Letter.)
19. Peloquin, C. A., A. A. MacPhee, and S. E. Berning. 1993. Malabsorption of antimycobacterial medications. N. Engl. J. Med. 329:1122-1123. (Letter.)
20. Peloquin, C. A., A. T. Nitta, W. J. Burman, K. F. Brudney, J. R. Miranda-Massari, M. E. McGuinness, et al. 1996. Low antituberculosis drug concentrations in patients with AIDS. Ann. Pharmacother. 30:919-923.
21. Pfizer Inc. 1999. Trovan I.V. package insert. Pfizer Inc., New York, N.Y.
22. Sahai, J., K. Gallicano, L. Swick, S. Tailor, G. Garber, I. Seguin, L. Oliveras, S. Walker, A. Rachlis, and D. W. Cameron. 1997. Reduced plasma concentrations of antituberculosis drugs in patients with HIV infection. Ann. Intern. Med. 127:289-293.
23. Smith, P. D., T. C. Quinn, W. Strober, E. N. Janoff, and H. Masur. 1992. Gastrointestinal infections in AIDS. Ann. Intern. Med. 116:63-77.
24. Teng, R., L. C. Dogolo, S. A. Willavize, H. L. Friedman, and J. Vincent. 1997. Oral bioavailability of trovafloxacin with and without food in healthy volunteers. J. Antimicrob. Chemother. 39(Suppl. B):87-92.
25. Teng, R., S. C. Harris, D. E. Nix, J. J. Schentag, G. Foulds, and T. E. Liston. 1995. Pharmacokinetics and safety of trovafloxacin (CP-99,219), a new quinolone antibiotic, following administration of single oral doses to healthy male volunteers. J. Antimicrob. Chemother. 36:385-394.
26. Teng, R., T. G. Tensfeldt, T. E. Liston, and G. Foulds. 1996. Determination of trovafloxacin, a new quinolone antibiotic, in biological samples by reversed-phase high-performance liquid chromatography. J. Chromatogr. B 675:53-59.
27. Ullrich, R., M. Zeitz, W. Heise, M. L'age, G. Hoffken, and E. O. Reicken. 1989. Small intestinal structure and function in patients infected with human immunodeficiency virus (HIV): evidence for HIV induced enteropathy. Ann. Intern. Med. 111:15-21.