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Volumn 9, Issue 6, 1999, Pages 704-708

The genome of the malaria parasite

Author keywords

[No Author keywords available]

Indexed keywords

MALARIA VACCINE;

EID: 0032785180     PISSN: 0959437X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-437X(99)00032-5     Document Type: Review
Times cited : (29)

References (48)
  • 1
    • 0031554803 scopus 로고    scopus 로고
    • World malaria situation in 1994: Population at risk
    • World malaria situation in 1994: population at risk. Wkly Epidemiol Rec. 72:1997;269-276.
    • (1997) Wkly Epidemiol Rec , vol.72 , pp. 269-276
  • 2
    • 0003638001 scopus 로고    scopus 로고
    • I.W. Sherman. Washington, DC: ASM Press. This book contains a collection of reviews on most aspects of malaria parasite biology and research
    • Sherman I.W. Malaria Parasite Biology, Pathogenesis, and Protection. 1998;ASM Press, Washington, DC. This book contains a collection of reviews on most aspects of malaria parasite biology and research.
    • (1998) Malaria Parasite Biology, Pathogenesis, and Protection
  • 3
    • 0032173731 scopus 로고    scopus 로고
    • Findings emerging from complete microbial genome sequences
    • Clayton R.A., White O., Fraser C.M. Findings emerging from complete microbial genome sequences. Curr Opin Microbiol. 1:1998;562-566.
    • (1998) Curr Opin Microbiol , vol.1 , pp. 562-566
    • Clayton, R.A.1    White, O.2    Fraser, C.M.3
  • 5
    • 0032811323 scopus 로고    scopus 로고
    • Plasmodium falciparum: Assignment of microsatellite markers to chromosomes by PFG-PCR
    • A description of the P. falciparum linkage map produced using microsatellite markers covering most of the genome
    • Su X.Z., Wellems T.E. Plasmodium falciparum: assignment of microsatellite markers to chromosomes by PFG-PCR. Exp Parasitol. 91:1999;367-369. A description of the P. falciparum linkage map produced using microsatellite markers covering most of the genome.
    • (1999) Exp Parasitol , vol.91 , pp. 367-369
    • Su, X.Z.1    Wellems, T.E.2
  • 6
    • 0027438327 scopus 로고
    • Gene sequence tags from Plasmodium falciparum genomic DNA fragments prepared by the 'genease' activity of mung bean nuclease
    • Reddy G.R., Chakrabarti D., Schuster S.M., Ferl R.J., Almira E.C., Dame J.B. Gene sequence tags from Plasmodium falciparum genomic DNA fragments prepared by the 'genease' activity of mung bean nuclease. Proc Natl Acad Sci USA. 90:1993;9867-9871.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 9867-9871
    • Reddy, G.R.1    Chakrabarti, D.2    Schuster, S.M.3    Ferl, R.J.4    Almira, E.C.5    Dame, J.B.6
  • 8
    • 0033179319 scopus 로고    scopus 로고
    • Genome projects, genetic analysis, and the changing landscape of malaria research
    • A review article from one of the leading malaria research groups providing their view of the anticipated impact of recent technological developments, including genome sequencing, on research leading to new drugs and vaccines against malaria
    • Wellems T.E., Su X., Ferdig M., Fidock D.A. Genome projects, genetic analysis, and the changing landscape of malaria research. Curr Opin Microbiol. 2:1999;415-419. A review article from one of the leading malaria research groups providing their view of the anticipated impact of recent technological developments, including genome sequencing, on research leading to new drugs and vaccines against malaria.
    • (1999) Curr Opin Microbiol , vol.2 , pp. 415-419
    • Wellems, T.E.1    Su, X.2    Ferdig, M.3    Fidock, D.A.4
  • 9
    • 0030800460 scopus 로고    scopus 로고
    • Funding assured for international malaria sequencing project
    • Butler D. Funding assured for international malaria sequencing project. Nature. 388:1997;701.
    • (1997) Nature , vol.388 , pp. 701
    • Butler, D.1
  • 11
    • 0029996805 scopus 로고    scopus 로고
    • Toward a high-resolution Plasmodium falciparum linkage map: Polymorphic markers from hundreds of simple sequence repeats
    • Su X.Z., Wellems T.E. Toward a high-resolution Plasmodium falciparum linkage map: polymorphic markers from hundreds of simple sequence repeats. Genomics. 33:1996;430-444.
    • (1996) Genomics , vol.33 , pp. 430-444
    • Su, X.Z.1    Wellems, T.E.2
  • 12
    • 0032976372 scopus 로고    scopus 로고
    • Optical mapping of Plasmodium falciparum chromosome 2
    • A report describing the rapid generation of restriction maps for an entire chromosome by direct visualization of restriction enzyme digested chromosome fragments on glass slides
    • Jing J., Aston C., Zhongwu L., Carucci D.J., Gardner M.J., Venter J.C., Schwartz D.C. Optical mapping of Plasmodium falciparum chromosome 2. Genome Res. 9:1999;175-181. A report describing the rapid generation of restriction maps for an entire chromosome by direct visualization of restriction enzyme digested chromosome fragments on glass slides.
    • (1999) Genome Res , vol.9 , pp. 175-181
    • Jing, J.1    Aston, C.2    Zhongwu, L.3    Carucci, D.J.4    Gardner, M.J.5    Venter, J.C.6    Schwartz, D.C.7
  • 13
    • 0033168288 scopus 로고    scopus 로고
    • Optical mapping and its potential for large-scale sequencing projects
    • Aston C., Mishra B., Schwartz D.C. Optical mapping and its potential for large-scale sequencing projects. Trends Biotechnol. 17:1999;297-302.
    • (1999) Trends Biotechnol , vol.17 , pp. 297-302
    • Aston, C.1    Mishra, B.2    Schwartz, D.C.3
  • 17
    • 0033178482 scopus 로고    scopus 로고
    • Antigenic variation in Plasmodium falciparum: Mechanisms and consequences
    • A concise summary of the progress being made towards understanding the process of antigenic variation in malaria parasites
    • Newbold C.I. Antigenic variation in Plasmodium falciparum: mechanisms and consequences. Curr Opin Microbiol. 2:1999;420-425. A concise summary of the progress being made towards understanding the process of antigenic variation in malaria parasites.
    • (1999) Curr Opin Microbiol , vol.2 , pp. 420-425
    • Newbold, C.I.1
  • 18
    • 0029052741 scopus 로고
    • Cloning the P. falciparum gene encoding PfEMP1, a malarial variant antigen and adherence receptor on the surface of parasitized human erythrocytes
    • Baruch D.I., Pasloske B.L., Singh H.B., Bi X., Ma X.C., Feldman M., Taraschi T.F., Howard R.J. Cloning the P. falciparum gene encoding PfEMP1, a malarial variant antigen and adherence receptor on the surface of parasitized human erythrocytes. Cell. 82:1995;77-87.
    • (1995) Cell , vol.82 , pp. 77-87
    • Baruch, D.I.1    Pasloske, B.L.2    Singh, H.B.3    Bi, X.4    Ma, X.C.5    Feldman, M.6    Taraschi, T.F.7    Howard, R.J.8
  • 19
    • 0029070914 scopus 로고
    • The large diverse gene family var encodes proteins involved in cytoadherence and antigenic variation of Plasmodium falciparum-infected erythrocytes
    • Su Z., Heatwole V.M., Wertheimer S.P., Guinet F., Herrfeldt J.A., Petersen D.S., Ravetch J., Wellems T.E. The large diverse gene family var encodes proteins involved in cytoadherence and antigenic variation of Plasmodium falciparum-infected erythrocytes. Cell. 82:1995;89-100.
    • (1995) Cell , vol.82 , pp. 89-100
    • Su, Z.1    Heatwole, V.M.2    Wertheimer, S.P.3    Guinet, F.4    Herrfeldt, J.A.5    Petersen, D.S.6    Ravetch, J.7    Wellems, T.E.8
  • 20
    • 0028982168 scopus 로고
    • Switches in expression of Plasmodium falciparum var genes correlate with changes in antigenic and cytoadherent phenotypes of infected erythrocytes
    • Smith J.D., Chitnis C.E., Craig A.G., Roberts D.J., Hudson-Taylor D.E., Petersen D.S., Pinches R., Newbold C.I., Miller L.H. Switches in expression of Plasmodium falciparum var genes correlate with changes in antigenic and cytoadherent phenotypes of infected erythrocytes. Cell. 82:1995;101-110.
    • (1995) Cell , vol.82 , pp. 101-110
    • Smith, J.D.1    Chitnis, C.E.2    Craig, A.G.3    Roberts, D.J.4    Hudson-Taylor, D.E.5    Petersen, D.S.6    Pinches, R.7    Newbold, C.I.8    Miller, L.H.9
  • 21
    • 0029047069 scopus 로고
    • Antigenic variation in malaria
    • Borst P., Bitter W., McCulloch R. Antigenic variation in malaria. Cell. 82:1995;1-4.
    • (1995) Cell , vol.82 , pp. 1-4
    • Borst, P.1    Bitter, W.2    McCulloch, R.3
  • 23
    • 0032583111 scopus 로고    scopus 로고
    • Stevor and rif are Plasmodium falciparum multicopy gene families which potentially encode variant antigens
    • A report characterizing novel multigene families encoding proteins involved in antigenic variation
    • Cheng Q., Cloonan N., Fischer K., Thompson J., Waine G., Lanzer M., Saul A. stevor and rif are Plasmodium falciparum multicopy gene families which potentially encode variant antigens. Mol Biochem Parasitol. 97:1998;161-176. A report characterizing novel multigene families encoding proteins involved in antigenic variation.
    • (1998) Mol Biochem Parasitol , vol.97 , pp. 161-176
    • Cheng, Q.1    Cloonan, N.2    Fischer, K.3    Thompson, J.4    Waine, G.5    Lanzer, M.6    Saul, A.7
  • 24
    • 0033529973 scopus 로고    scopus 로고
    • Rifins: A second family of clonally variant proteins expressed on the surface of red cells infected with Plasmodium falciparum
    • An article that provides the biological and immunological evidence supporting the classification of the rifins as a novel family of variant surface antigens
    • Kyes S.A., Rowe J.A., Kriek N., Newbold C.I. Rifins: a second family of clonally variant proteins expressed on the surface of red cells infected with Plasmodium falciparum. Proc Natl Acad Sci USA. 96:1999;9333-9338. An article that provides the biological and immunological evidence supporting the classification of the rifins as a novel family of variant surface antigens.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 9333-9338
    • Kyes, S.A.1    Rowe, J.A.2    Kriek, N.3    Newbold, C.I.4
  • 25
    • 0344549379 scopus 로고    scopus 로고
    • Nuclear-encoded proteins target to the plastid in Toxoplasma gondii and Plasmodium falciparum
    • Several nuclear-encoded proteins from Toxoplasma and Plasmodium that are transported into the apicoplast are described and the apicoplast targeting sequences are identified. Also, a new drug target expressed in the apicoplast is described
    • Waller R.F., Keeling P.J., Donald R.G.K., Striepen B., Handman E., Lang-Unnasch N., Cowman A.F., Besra G.S., Roos D.S., McFadden G.I. Nuclear-encoded proteins target to the plastid in Toxoplasma gondii and Plasmodium falciparum. Proc Natl Acad Sci USA. 95:1998;12352-12357. Several nuclear-encoded proteins from Toxoplasma and Plasmodium that are transported into the apicoplast are described and the apicoplast targeting sequences are identified. Also, a new drug target expressed in the apicoplast is described.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 12352-12357
    • Waller, R.F.1    Keeling, P.J.2    Donald, R.G.K.3    Striepen, B.4    Handman, E.5    Lang-Unnasch, N.6    Cowman, A.F.7    Besra, G.S.8    Roos, D.S.9    McFadden, G.I.10
  • 29
    • 0031850991 scopus 로고    scopus 로고
    • Evidence for a single origin of the 35 kb plastid DNA in apicomplexans
    • Denny P., Preiser P., Williamson D., Wilson I. Evidence for a single origin of the 35 kb plastid DNA in apicomplexans. Protist. 149:1998;51-59.
    • (1998) Protist , vol.149 , pp. 51-59
    • Denny, P.1    Preiser, P.2    Williamson, D.3    Wilson, I.4
  • 30
    • 0032211044 scopus 로고    scopus 로고
    • Plastids are widespread and ancient in parasites of the phylum Apicomplexa
    • Lang-Unnasch N., Reith M.E., Munholland J., Barta J.R. Plastids are widespread and ancient in parasites of the phylum Apicomplexa. Int J Parasitol. 28:1998;1743-1754.
    • (1998) Int J Parasitol , vol.28 , pp. 1743-1754
    • Lang-Unnasch, N.1    Reith, M.E.2    Munholland, J.3    Barta, J.R.4
  • 31
    • 0032987667 scopus 로고    scopus 로고
    • The apicoplast as a potential therapeutic target in Toxoplasma and other apicomplexan parasites
    • Soldati D. The apicoplast as a potential therapeutic target in Toxoplasma and other apicomplexan parasites. Parasitol Today. 15:1999;5-7.
    • (1999) Parasitol Today , vol.15 , pp. 5-7
    • Soldati, D.1
  • 32
    • 0032815207 scopus 로고    scopus 로고
    • Apicomplexan plastids as drug targets
    • McFadden G.I., Roos D.S. Apicomplexan plastids as drug targets. Trends Microbiol. 7:1999;328-333.
    • (1999) Trends Microbiol , vol.7 , pp. 328-333
    • McFadden, G.I.1    Roos, D.S.2
  • 33
    • 0033520336 scopus 로고    scopus 로고
    • Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs
    • This report documents the discovery, using genome sequence information, of a novel drug target in the apicoplast. This is perhaps the most spectacular example to date of the use of genome sequence data to identify new drug targets in Plasmodium and related parasites
    • Jomaa H., Wiesner J., Sanderbrand S., Altincicek B., Weidemeyer C., Hintz M., I T.r., Eberl M., Zeidler J., Lichtenthaler H.K.et al. Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs. Science. 285:1999;1573-1576. This report documents the discovery, using genome sequence information, of a novel drug target in the apicoplast. This is perhaps the most spectacular example to date of the use of genome sequence data to identify new drug targets in Plasmodium and related parasites.
    • (1999) Science , vol.285 , pp. 1573-1576
    • Jomaa, H.1    Wiesner, J.2    Sanderbrand, S.3    Altincicek, B.4    Weidemeyer, C.5    Hintz, M.6    I, T.R.7    Eberl, M.8    Zeidler, J.9    Lichtenthaler, H.K.10
  • 34
    • 0033520437 scopus 로고    scopus 로고
    • Planting the seeds of new antimalarial drugs
    • Ridley R.G. Planting the seeds of new antimalarial drugs. Science. 285:1999;1502-1503.
    • (1999) Science , vol.285 , pp. 1502-1503
    • Ridley, R.G.1
  • 35
    • 0032565968 scopus 로고    scopus 로고
    • Evidence for the shikimate pathway in apicomplexan parasites
    • The shikimate pathway of chorismate biosynthesis is found in plants, algae, fungi, and bacteria. Chorismate is essential for folate biosynthesis in these organisms and compounds that inhibit enzymes of the shikimate pathway have antimicrobial and herbicidal properties. This paper demonstrates that there is a functional shikimate pathway in Plasmodium and related parasites. Because this pathway is not found in mammals, the enzymes of the shikimate pathway may represent new chemotherapeutic targets for antimalarial drugs
    • Roberts F., Roberts C.W., Johnson J.J., Kyle D.E., Krell T., Coggins J.R., Coombs G.H., Milhous W.K., Tzipori S., Ferguson D.J.et al. Evidence for the shikimate pathway in apicomplexan parasites. Nature. 393:1998;801-805. The shikimate pathway of chorismate biosynthesis is found in plants, algae, fungi, and bacteria. Chorismate is essential for folate biosynthesis in these organisms and compounds that inhibit enzymes of the shikimate pathway have antimicrobial and herbicidal properties. This paper demonstrates that there is a functional shikimate pathway in Plasmodium and related parasites. Because this pathway is not found in mammals, the enzymes of the shikimate pathway may represent new chemotherapeutic targets for antimalarial drugs.
    • (1998) Nature , vol.393 , pp. 801-805
    • Roberts, F.1    Roberts, C.W.2    Johnson, J.J.3    Kyle, D.E.4    Krell, T.5    Coggins, J.R.6    Coombs, G.H.7    Milhous, W.K.8    Tzipori, S.9    Ferguson, D.J.10
  • 36
    • 0031928155 scopus 로고    scopus 로고
    • Planting new targets for antiparasitic drugs
    • Ridley R.G. Planting new targets for antiparasitic drugs. Nat Med. 4:1998;894-995.
    • (1998) Nat Med , vol.4 , pp. 894-995
    • Ridley, R.G.1
  • 37
    • 0033548624 scopus 로고    scopus 로고
    • Intraerythrocytic Plasmodium falciparum expresses a high affinity facilitative hexose transporter
    • Woodrow C.J., Penny J.I., Krishna S. Intraerythrocytic Plasmodium falciparum expresses a high affinity facilitative hexose transporter. J Biol Chem. 274:1999;7272-7277.
    • (1999) J Biol Chem , vol.274 , pp. 7272-7277
    • Woodrow, C.J.1    Penny, J.I.2    Krishna, S.3
  • 38
    • 0031960217 scopus 로고    scopus 로고
    • Research toward vaccines against malaria
    • Miller L.H., Hoffman S.L. Research toward vaccines against malaria. Nat Med. 4:1998;520-524.
    • (1998) Nat Med , vol.4 , pp. 520-524
    • Miller, L.H.1    Hoffman, S.L.2
  • 39
    • 0033178522 scopus 로고    scopus 로고
    • Immune effector mechanisms in malaria
    • Good M.F., Doolan D.L. Immune effector mechanisms in malaria. Curr Opin Immunol. 11:1999;412-419.
    • (1999) Curr Opin Immunol , vol.11 , pp. 412-419
    • Good, M.F.1    Doolan, D.L.2
  • 40
    • 0031728356 scopus 로고    scopus 로고
    • From genomics to vaccines: Malaria as a model system
    • This article points out that new, high-throughput strategies for the identification and testing of potential vaccine targets must be devised if the full benefits from the enormous amounts of sequence data being generated by the Malaria Genome Project are to be realized. It is proposed that DNA vaccine technology can be used to determine the stage-specificity and subcellular localization of proteins predicted from the genome sequence, and that this information can be used to select antigens for vaccine development
    • Hoffman S.L., Rogers W.O., Carucci D.J., Venter J.C. From genomics to vaccines: malaria as a model system. Nat Med. 4:1998;1351-1353. This article points out that new, high-throughput strategies for the identification and testing of potential vaccine targets must be devised if the full benefits from the enormous amounts of sequence data being generated by the Malaria Genome Project are to be realized. It is proposed that DNA vaccine technology can be used to determine the stage-specificity and subcellular localization of proteins predicted from the genome sequence, and that this information can be used to select antigens for vaccine development.
    • (1998) Nat Med , vol.4 , pp. 1351-1353
    • Hoffman, S.L.1    Rogers, W.O.2    Carucci, D.J.3    Venter, J.C.4
  • 41
    • 0028863527 scopus 로고
    • Protection against mycoplasma infection infection using expression-library immunization
    • Barry M.A., Lai W.C., Johnston S.A. Protection against mycoplasma infection infection using expression-library immunization. Nature. 377:1995;632-635.
    • (1995) Nature , vol.377 , pp. 632-635
    • Barry, M.A.1    Lai, W.C.2    Johnston, S.A.3
  • 42
    • 0030927831 scopus 로고    scopus 로고
    • Continuous in vitro propagation of the malaria parasite Plasmodium vivax
    • Golenda C.F., Li J., Rosenberg R. Continuous in vitro propagation of the malaria parasite Plasmodium vivax. Proc Natl Acad Sci USA. 94:1997;6786-6791.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 6786-6791
    • Golenda, C.F.1    Li, J.2    Rosenberg, R.3
  • 43
    • 0032998957 scopus 로고    scopus 로고
    • Karyotype and synteny among the chromosomes of all four species of human malaria parasite
    • This article describes the use of pulsed field gel electrophoresis to produce karyotype maps of all four species of malaria parasites that infect humans. All four species appeared to contain 14 chromosomes, but the chromosomes of P. vivax, P. ovale, and P. malariae were found to be larger than those of P. falciparum. Four of five synteny groups that are conserved between P. falciparum and rodent malarias were conserved in all four human malaria parasites despite the differences in chromosome size
    • Carlton J.M., Galinski M.R., Barnwell J.W., Dame J.B. Karyotype and synteny among the chromosomes of all four species of human malaria parasite. Mol Biochem Parasitol. 101:1999;23-32. This article describes the use of pulsed field gel electrophoresis to produce karyotype maps of all four species of malaria parasites that infect humans. All four species appeared to contain 14 chromosomes, but the chromosomes of P. vivax, P. ovale, and P. malariae were found to be larger than those of P. falciparum. Four of five synteny groups that are conserved between P. falciparum and rodent malarias were conserved in all four human malaria parasites despite the differences in chromosome size.
    • (1999) Mol Biochem Parasitol , vol.101 , pp. 23-32
    • Carlton, J.M.1    Galinski, M.R.2    Barnwell, J.W.3    Dame, J.B.4
  • 44
    • 0032169874 scopus 로고    scopus 로고
    • Organisation and informational content of the Theileria parva genome
    • Theileria parva is a cattle parasite that is transmitted by ticks and is related to Plasmodium and Toxoplasma. T. parva infects the lymphocytes of the host and causes a lymphoproliferative disorder called East Coast Fever. This article reviews current knowledge of the T. parva genome, which is one-third the size of the P. falciparum genome. Sequencing of T. parva genome would assist the characterization of the malaria parasite genome and may also shed light on the mechnisms of T. parva-induced host-cell transformation
    • Nene V., Morzaria S., Bishop R. Organisation and informational content of the Theileria parva genome. Mol Biochem Parasitol. 95:1998;1-8. Theileria parva is a cattle parasite that is transmitted by ticks and is related to Plasmodium and Toxoplasma. T. parva infects the lymphocytes of the host and causes a lymphoproliferative disorder called East Coast Fever. This article reviews current knowledge of the T. parva genome, which is one-third the size of the P. falciparum genome. Sequencing of T. parva genome would assist the characterization of the malaria parasite genome and may also shed light on the mechnisms of T. parva-induced host-cell transformation.
    • (1998) Mol Biochem Parasitol , vol.95 , pp. 1-8
    • Nene, V.1    Morzaria, S.2    Bishop, R.3
  • 46
    • 84984934048 scopus 로고    scopus 로고
    • DNA microarrays in drug discovery and development
    • Debouck C., Goodfellow P.N. DNA microarrays in drug discovery and development. Nat Genet. 21:1999;48-50.
    • (1999) Nat Genet , vol.21 , pp. 48-50
    • Debouck, C.1    Goodfellow, P.N.2
  • 48
    • 0032727009 scopus 로고    scopus 로고
    • A shotgun optical map of the entire Plasmodium falciparum genome
    • ••], where optical restriction mapping was used to rapidly prepare a restriction map of P. falciparum chromosome 2. In this paper, an optical restriction map of the complete P. falciparum genome was constructed. Optical maps of P. falciparum chromosomes have proven very useful for gap closure and sequence verification. Optical restriction maps may be very useful in the sequencing of Plasmodium genomes for which other physical or genetic maps are not available
    • ••], where optical restriction mapping was used to rapidly prepare a restriction map of P. falciparum chromosome 2. In this paper, an optical restriction map of the complete P. falciparum genome was constructed. Optical maps of P. falciparum chromosomes have proven very useful for gap closure and sequence verification. Optical restriction maps may be very useful in the sequencing of Plasmodium genomes for which other physical or genetic maps are not available.
    • (1999) Nat Genet , vol.23 , pp. 309-313
    • Lai, Z.1    Jing, J.2    Aston, C.3    Clarke, V.4    Apodaca, J.5    Dimalanta, E.T.6    Carucci, D.J.7    Gardner, M.J.8    Mishra, B.9    Anantharaman, T.S.10


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