The effect of deep pore mutations on the action of phenylalkylamines on the Kv1.3 potassium channel

British Journal of Pharmacology

Volumn 127, Issue 5, 1999, Pages 1065-1074

  Rauer, Heiko ^a   Grissmer, Stephan ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF ULM   (Germany)

Author keywords

Drug binding site; Intracellular P region; L type Ca2+ and Na+ channels binding mechanism; Phenylalkylamine; Verapamil; Voltage gated K+ channel

Indexed keywords

CALCIUM CHANNEL; CHARYBDOTOXIN; LOCAL ANESTHETIC AGENT; N METHYLVERAPAMIL; PHENYLALKYLAMINE; POTASSIUM CHANNEL; SODIUM CHANNEL; TETRYLAMMONIUM; UNCLASSIFIED DRUG; VERAPAMIL;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; CRYSTALLIZATION; DRUG BINDING; DRUG BINDING SITE; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; RAT;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CALCIUM CHANNELS; CALCIUM CHANNELS, L-TYPE; CRYSTALLIZATION; KV1.3 POTASSIUM CHANNEL; MODELS, STRUCTURAL; MOLECULAR SEQUENCE DATA; MUTATION; POTASSIUM CHANNELS; POTASSIUM CHANNELS, VOLTAGE-GATED; RATS; SODIUM CHANNELS; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAETHYLAMMONIUM COMPOUNDS; TUMOR CELLS, CULTURED; VERAPAMIL;

EID: 0032784485     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0702599     Document Type: Article

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