High incidence of maternal HLA A, B and C antibodies associated with a mild course of haemolytic disease of the newborn

European Journal of Haematology

Volumn 63, Issue 2, 1999, Pages 120-125

  Neppert, J ^a   Witzleben Schurholz E V ^a   Zupanska, B ^b   Bartz, L ^a   Greve, O ^a   Eichler, H ^c   Kerowgan, M ^c   Wichmann, M G ^a  

^a UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^b INSTITUTE OF HEMATOLOGY AND TRANSFUSION MEDICINE   (Poland)

^c M B C of the G R C S B W   (Germany)

Author keywords

Haemolytic disease of the newborn; Protective HLA antibodies

Indexed keywords

HLA A ANTIGEN; HLA ANTIBODY; HLA ANTIGEN; HLA B ANTIGEN; HLA C ANTIGEN; HLA DR ANTIGEN; MATERNAL ANTIBODY; RHESUS ANTIGEN;

ANTIBODY PRODUCTION; ARTICLE; BLOOD GROUP RH; CHILDBIRTH; CONTROLLED STUDY; DISEASE COURSE; FEMALE; HUMAN; HUMAN TISSUE; INCIDENCE; MAJOR CLINICAL STUDY; NEWBORN HEMOLYTIC DISEASE; PRIORITY JOURNAL;

EID: 0032784123     PISSN: 09024441     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0609.1999.tb01125.x     Document Type: Article

References (22)

1. 1. NEPPERT J, MARQUARD F, MUELLER-ECKHARDT C. Murine monoclonal antibodies and human alloantisera specific for HLA inhibit monocyte phagocytosis of anti-D sensitized human red blood cells. Eur J Immunol 1985;15:559-563.
2. 2. NEPPERT J, JUNGI TW. Antibodies to human major histocompatibility complex products inhibit Fcγ receptors type I and II. Transfusion Med 1996;6:125-131.
3. 3. NEPPERT J, MUELLER-ECKHARDT G, HEINE O. Reduced immune phagocytosis of monocytes from neonates whose mothers produce HLA antibodies. Vox Sang 1988;54:177-180.
4. 4. NEPPERT J, KISSEL K. Protection against immune haemolytic disease of newborn infants by maternal monocyte-reactive IgG alloantibodies. Lancet 1992; 339:1481.
5. 5. NEPPERT J. Rhesus-D and -D incompatibility in the newborn without haemolytic disease: immune phagocytosis inhibition? Vox Sang 1987;53:239.
6. 6. DOOREN MC, KUUPERS RWAM, JOEKES EC, et al. Protection against immune haemolytic disease of newborn infants by maternal monocyte-reactive IgG alloantibodies (anti-HLA-DR). Lancet 1992;339: 1067-1070.
7. 7. SHEPARD SL, NOBLE AL, FILBEY D, et al. Inhibition of the monocyte chemiluminescent response to anti-D-sensitized red cells by FcγRI-blocking antibodies which ameliorate the severity of haemolytic disease of the newborn. Vox Sang 1996;70:157-163.
8. 8. TERASAKI PI, MCCLELLAND JD. Microdroplet assay of human serum cytotoxins. Nature (London) 1964; 204:998-1000.
9. 9. National Institute of Health. NIH lymphocyte microcytotoxicity technique. In: Manual of Tissue Typing Techniques 1974;20.
10. 10. FAUST A, NEPPERT J. Detection of antibodies specific for HLA-A, B, C, DR, DQ and DP by the erythrocyte antibody rosette inhibition (EAI) and immune phagocytosis inhibition (IPI) test. J Immunol Methods 1987;102:71-75.
11. 11. FLESCH BK, ACHTERT G, NEPPERT J. Inhibition of monocyte and polymorphonuclear granulocyte immune phagocytosis by monoclonal antibodies specific for FcγRI, II and III. Ann Hematol 1997;74:15-22.
12. 12. NEPPERT J, POHL E, MUELLER-ECKHARDT C. Inhibition of immune phagocytosis by human sera with HLA A, B, C, DR, but not with DQ or EM type reactivity. Vox Sang 1986;51:122-126.
13. 13. PHILIPP M, CASSENS K, HERWARTZ K, et al. Comparison of different assays for the determination of HLA specific antibodies. Immunobiol 1996;196:258.
14. 14. AHRONS S, GLAVIND-KRISTENSEN S. Cytotoxic HL-A antibodies: Immunoglobulin classification. Tissue Antigens 1971;1:129-136.
15. 15. MOULINIER J, MESNIER F, MERLE M-C. L'incompatibilité HL-A entre le foetus et sa mère. Rev. Française Transfusion 1971;14:209-217.
16. 16. HÜBEL E, BERTRAMS E, KUWERT W, et al. Häufigkeit und Bedeutung von Leukozyten-Isoantikörpern bei Frauen mit Rhesusunverträglichkeit. Z Immunit Forschung 1972;143:411-418.
17. 17. MUELLER-ECKHARDT G, KIEFEL V, TLUSTY A, et al. Incidence and specificity of HLA-DP antibodies in pregnancy sera. Human Immunol 1990;29:166-174.
18. 18. KIEFEL V, FREITAG E, KROLL H, et al. Platelet autoantibodies (IgG, IgM, IgA) against glycoproteins IIb/IIIa and Ib/IX in patients with thrombocytopenia. Ann Hematol 1996;72:280-285.
19. 19. PETZ LD, SWISHER SN, KLEINMAN S, et al. Clinical Practice of Transfusion Medicine. 3rd edn., New York: Churchill Livingstone 1996;473.
20. 20. ENGELFRIET CP. The immune destruction of red cells. Transfusion Medicine 1992;2:1-6.
21. 21. ZUPANSKA B, BROJER E, RICHARDS Y, et al. Serological and immunological characteristics of maternal anti-Rh (D) antibodies in predicting the severity of haemolytic disease of the newborn. Vox Sang 1989;56:247-253.
22. 22. FAUST A, NEPPERT J, KISSEL K. Circulatory clearance of transfused antibody-sensitised red cells in an entirely allogenic rabbit model. Infusionsther 1994;21: 260-264.