Bone regeneration with recombinant human bone morphogenetic protein-2 (rhBMP-2) using absorbable collagen sponges (ACS): Influence of processing on ACS characteristics and formulation

Pharmaceutical Development and Technology

Volumn 4, Issue 3, 1999, Pages 387-396

  Friess, Wolfgang ^a   Uludag, Hasan ^b   Foskett, Shannon ^c   Biron, Robert ^c  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b UNIVERSITY OF ALBERTA   (Canada)

^c PFIZER INC   (United States)

Author keywords

Bone morphogenetic protein; Collagen; Cross linking; Sterilization

Indexed keywords

BONE MORPHOGENETIC PROTEIN 2; COLLAGEN; COLLAGEN FIBER; COLLAGENASE; RECOMBINANT BONE MORPHOGENETIC PROTEIN 2; UNCLASSIFIED DRUG;

AMINO ACID ANALYSIS; ARTICLE; BONE REGENERATION; CROSS LINKING; DIFFERENTIAL SCANNING CALORIMETRY; DRUG MANUFACTURE; INSTRUMENT STERILIZATION; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN DENATURATION; PROTEIN PROCESSING; PROTEIN STRUCTURE; SCANNING ELECTRON MICROSCOPY; SPONGE; TRANSMISSION ELECTRON MICROSCOPY;

ABSORBABLE IMPLANTS; ABSORPTION; AMINES; BONE MORPHOGENETIC PROTEINS; BONE REGENERATION; COLLAGEN; ELECTRIC CONDUCTIVITY; EXCIPIENTS; HUMANS; HYDROGEN-ION CONCENTRATION; INFUSION PUMPS, IMPLANTABLE; MICROSCOPY, ELECTRON; MICROSCOPY, ELECTRON, SCANNING; PROTEIN DENATURATION; RECOMBINANT PROTEINS; TEMPERATURE; TRANSFORMING GROWTH FACTOR BETA;

EID: 0032783421     PISSN: 10837450     EISSN: None     Source Type: Journal    
DOI: 10.1081/PDT-100101374     Document Type: Article

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