Influence of theophylline on urinary excretion of total, free and acyl carnitine in rats

In Vivo

Volumn 13, Issue 3, 1999, Pages 225-229

  Al Kholaifi, A M ^a   Alhomida, A S ^b  

^a Prince Sultan Military Medical City   (Saudi Arabia)

^b KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

Carnitine; Lipolysis; Rat; Theophylline; Urine

Indexed keywords

CARNITINE; PLACEBO; THEOPHYLLINE;

ANIMAL EXPERIMENT; ARTICLE; CARNITINE DEFICIENCY; CONTROLLED STUDY; FOOD INTAKE; KIDNEY TUBULE ABSORPTION; LIPID METABOLISM; NONHUMAN; RANDOMIZATION; RAT; URINARY EXCRETION;

EID: 0032780171     PISSN: 0258851X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. Bieber LL: Carnitine. Ann Rev Biochem 57; 261-283, 1988.
2. McGarry JD, Faster CA: Regulation of hepatic fatty acid oxidation and ketone body production. Ann Rev Biochem 49: 395-420, 1980.
3. Paul H, Adibi SA: Effect of carnitine on branched-chain amino acid oxidation by liver and skeletal muscle. Am J Physiol 234: E494-E499, 1978.
4. Alhomida AS, Duhaiman AS, Al-Jafari AA, Junaid MA: Determination of L-carnitine, acylcarnitine and total carnitine levels in plasma and tissues of camel (Camelus dromedarius). Comp Biochem Physiol 111B: 441-445, 1995.
5. Marzo A, Cardace G, Corbelletta C, Pace S, D'Iddio S, Verrotti C: Plasma concentration, urinary excretion and renal clearance of L-carnitine during pregnancy: a reversible secondary L-carnitine deficiency. Gynecol Endorinol 8: 115-120, 1994.
6. Alhomida AS, Al-Jafari AA, Junaid MA, Al-Whaiby, SA. Duhaiman, A.S: Age, sex and diabetes-related changes in total, free and acylcarnitine in human plasma. Med Sci Res 23: 167-169, 1995.
7. Alhomida AS, Duhaiman AS, Al-Jafari AA, Sobki S, Al-Sulaiman M, Al-Khader A: Serum total, free and acyl carnitine concentrations in chronic glomerulonephritis patients. Med Sci Res 24: 495-498, 1996.
8. Alhomida AS: Effect of chronic renal hemodialysis on serum total, free and acyl carnitine concentrations in adult chronic pyelonephritis patients. Arch Med Res 28: 101-107, 1997.
9. Alhomida AS, Sobki SH, Al-Sulaiman MH, Al-Khadar AA: Influence of gender and chronic hemodialysis treatments on total, free and acyl carnitine concentrations in human serum. Int Urol Nephrol 29: 479-487, 1997.
10. Bohles H, Evangeliou A, Bervoets K, Eckert I, Sewell A: Carnitine esters in metabolic diseases. Eur J Pediatr 153: 557-561, 1994.
11. Aranda JV, Turmen T: Methylxanthines in apnea of prematurity. Clin Perinatol 6: 87-107, 1979.
12. Jacobs MH, Senior RM, Kessler G: Clinical experience with theophylline. Relationship between dosage, serum concentration and toxicity. J Am Med Assoc 255: 1983-1986, 1976.
13. Scotini E, Carpenedo F, Fassina G: New derivatives of methylxanthines: Effects of thiocaffeine, thiotheophylline and 8-phenyltheophylline on lipolysis and on phosphodiesterase activities. Pharmacol Res Commun 15: 131 143, 1983.
14. Fredholm BB, Lindgren E: The effect of alkylxanthines and other phosphodiesterase inhibitors on adenosine-receptor mediated decrease in lipolysis and cyclic AMP accumulations in rat fat cells. Acta Pharmacol Toxicol 54: 64-71, 1984.
15. Alhomida AS: Investigation of the effect of theophylline administration on total, free, short-chain acyl and long-chain acyl carnitine distributions in rat renal tissues. Cell Biochem Func 16: 165- 171, 1998.
16. Alhomida AS: Study of the effects of theophylline-related changes in total, free, short-chain acyl and long-chain acyl carnitine concentrations in rat heart. Toxicol 121: 205- 213, 1997.
17. Al-Jafari AA, Junaid MA, Alhomida AS: Investigation of the influence of theophylline feeding on total, free, short-chain acyl and long-chain acyl carnitine levels in skeletal muscle and liver of rats. In vivo 10: 569-574, 1996.
18. Alhomida AS: Total, free, short-chain, long-chain acyl carnitine levels in Arabian camel milk (Camelus dromedarius). Ann Nurt Metabol 40: 221-226, 1996.
19. Al-Kholaifi AM, Alhomida AS: Evaluation of theophylline-induced changes on plasma total, free, short-chain acyl and long-cham acyl carnitine concentrations in rats. Med Sci Res 25: 31-34, 1997.
20. Heinegard D, Tiderstrom G. Determination of serum crcatinine by a direct colorimetric method. Clin Chim Acta 43: 305-310, 1973.
21. Scammell JG, Fregly MJ: Effect of theophylline on thyroid status in the rat. Pharmacol 25: 160-169, 1982.
22. Bukowiecki LJ, Lupien J, Follea N, Jahjah L: Effects of sucrose, caffeine and cola beverages on obesity, cold resistance and adipose tissue cellularity. Am J Physiol 1244: R500-R507, 1983.
23. Field M: Intestinal secretion: effect of cyclic AMP and its role in cholera. N Engl J Med 284: 1137-1142, 1971.
24. Miller M, Opheim KE, Raisys VA, Motulsky AG: Theophylline metabolism: variation and genetics. Clin Pharm Ther 35: 170-182, 1992.
25. Hokland B, Bremer J: Metabolism and excretion of carnitine and acylcarnitine in the perfused rat kidney. Biochem Biophys Acta 886: 223-241, 1986.
26. Spindel E: Action of methylxanthines on the pituitary and pitutary-dependent hormones. In: The methyxanthine beverages and foods: chemistry, consumption, and health effects. New York, Alan R Liss, Inc 1984, pp 331-355.
27. Rebouche CJ: Carnitine transport and tissue carnitine accretion in rats. Biochim Biophys Acta 1033: 111-113, 1989.
28. Alhomida AS, Al-Jafari AA, Duhaiman AS, Rabbani N, Junaid MA: Kinetic properties of purified carnitine acetyltransferase from the skeletal muscle of the Arabian camel (Camelus dromedarius). Biochimie 78: 204-208, 1996.
29. Alhomida AS: Investigations of the effects o theophylline admi-nistration on carnitine acetyltransferase activity of rat heart. J Enz Inhib 12: 291-302, 1997.