The immunohistochemical expression of BCL-2 oncoprotein in colorectal adenocarcinoma

Surgery Today

Volumn 29, Issue 7, 1999, Pages 682-684

  Ishijima, Naoto ^a   Miki, Chikao ^a   Ishida, Tomomi ^a   Kinoshita, Tsuneki ^a   Suzuki, Hiroshi ^a  

^a MIE UNIVERSITY HOSPITAL   (Japan)

Author keywords

Bcl 2 oncoprotein; Colorectal cancer

Indexed keywords

PROTEIN BCL 2;

ADENOCARCINOMA; APOPTOSIS; ARTICLE; CANCER INVASION; CANCER STAGING; CANCER SURVIVAL; CELL DEATH; CLINICAL ARTICLE; COLORECTAL CANCER; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LIVER METASTASIS; PROTEIN EXPRESSION; RECURRENCE RISK; SURVIVAL RATE; TUMOR SUPPRESSOR GENE; TUMOR VOLUME;

EID: 0032779393     PISSN: 09411291     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02483002     Document Type: Article

References (14)

1. Korsmeyer SJ (1992) Bcl-2 initiates a new category of oncogenes: regulator of cell death. Blood 80:879-886
2. Tsujimoto Y, Finger LR, Yunis J, Nowell PC, Croce CM (1984) Cloning of the chromosome breakpoint of neoplastic B cells with the t (14;18) chromosome translocation. Science 226:1097-1099
3. Yan J-J, Chen F-F, Tsai Y-C, Jin Y-T (1996) Immunohistochemical detection of Bcl-2 protein in small cell carcinomas. Oncology 53:6-11
4. Astler VB, Coller FA (1954) The prognostic significance of direct extension of carcinoma of the colon and rectum. Ann Surg 139:846-852
5. Baretton GB, Dieold J, Christoforis G, Vogt M, Muller C, Dopfer K, Schneiderbanger K, Schmidt M, Lohrs U (1996) Apoptosis and immunohistochemical bcl-2 expression in colorectal adenomas and carcinomas. Aspects of carcinogenesis and prognostic significance. Cancer 77:255-264
6. Kaklamanis L, Savage A, Mortensen N, Tsiotos P, Doussis-Anadgnostopolou I, Biddolph S, Whitehouse R, Harris AL, Gatter KC (1996) Early expression of bcl-2 protein in the adenoma-carcinoma sequence of colorectal neoplasia. J Pathol 179:10-14
7. Hao XP, Ilyas M, Taibot IC (1997) Expression of bcl-2 and p53 in The colorectal adenoma-carcinoma sequence. Pathobiology 65:140-145
8. Perreira H, Silva S, Juliao R, Garcia P, Perpetua F (1997) Prognostic markers for colorectal cancer: expression of p53 and bcl-2. World J Surg 21:210-213
9. Bosari S, Moneghini L, Graziani D, Lee AKC, Murray JJ, Coggi G, Viale G (1995) Bcl-2 oncoprotein in colorectal hyperplasia polyps, adenomas, and adenocarcinomas. Hum Pathol 26:534-540
10. Oefner D, Riehemann K, Maier H, Riedmann B, Nehoda H, Toetsch M, Boecker W, Jasani B, Schnid KW (1995) Immunohistochemically detectable bcl-2 expression in colorectal carcinoma: correlation with tumour stage and patient survival. Br J Cancer 72:981-985
11. Bhatavdekar JM, Pater DD, Ghosh N, Chikhkilar PR, Trivede TI, Suthar TP, Doctor SS, Sha NG, Balar DB (1977) Coexpression of bcl-2, c-myc, and p53 oncoprotein as prognostic discriminants in patients with colorectal carcinoma. Dis Colon Rectum 40:785-790
12. Miyashita T, Krajewski S, Krajewska M, Wang HG, Lin HK, Liebermann DA, Hoffman B, Reed JC (1994) Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo. Oncogene 9:1799-1805
13. Marin MC, Hsu B, Meyn RE, Donehower LA, El-Naggar AK, Mcdonnell TJ (1994) Evidence that p53 and bcl-2 are regulators of a common cell death pathway important for in vivo lymphomagenesis. Oncogene 9:3107-3112
14. Halder S, Negrini M, Monne M, Sabbioni S, Croce CM (1994) Down regulation of bcl-2 byp53 in breast cancer cells. Cancer Res 54:2095-2097