Remission of insulin autoimmune syndrome in a patient with Graves' disease by treatment with methimazole

Internal Medicine

Volumn 38, Issue 6, 1999, Pages 482-485

  Okabe, Reiko ^a   Inaba, Masaaki ^a   Hosoi, Masayuki ^a   Ishimura, Eiji ^a   Kumeda, Yasuro ^a   Nishizawa, Yoshiki ^a   Morii, Hirotoshi ^a   Yamashita, Hiroyuki ^b  

^a OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

Author keywords

Graves' disease (GD); Human lymphocyte antigen (HLA) typing; Methimazole (MMI)

Indexed keywords

HLA B ANTIGEN; HLA C ANTIGEN; HLA DR4 ANTIGEN; IMMUNOREACTIVE INSULIN; INSULIN ANTIBODY; LIOTHYRONINE; THIAMAZOLE; THYROXINE;

ADULT; ANTIBODY TITER; ARTICLE; AUTOIMMUNE DISEASE; CASE REPORT; CLINICAL FEATURE; DISEASE ASSOCIATION; FREE LIOTHYRONINE INDEX; FREE THYROXINE INDEX; GRAVES DISEASE; HLA TYPING; HUMAN; INSULIN AUTOIMMUNE SYNDROME; INSULIN BLOOD LEVEL; MALE; REMISSION;

EID: 0032778984     PISSN: 09182918     EISSN: None     Source Type: Journal    
DOI: 10.2169/internalmedicine.38.482     Document Type: Article

References (14)

1. Hirata Y, Ishizu H. Elevated insulin-binding capacity of serum proteins in a case with spontaneous hypoglycemia and mild diabetes not treated with insulin. Tohoku J Exp Med 107: 277-286, 1972.
2. Takayama-Hasumi S, Eguchi Y, Sato A, Morita C, Hirata Y. Insulin autoimmune syndrome is the third leading cause of spontaneous hypoglycemic attacks in Japan. Diabetes Res Clin Prac 10, 211-214, 1990.
3. Hirata Y, Tominaga M, Ito JI, Noguchi A. Spontaneous hypoglycemia with insulin autoimmunity in Graves' disease. Ann Intern Med 81: 214-218, 1974.
4. Bruch HB, Clement S, Sokol MS, Landry F. Reactive hypoglycemic coma due to insulin autoimmune syndrome: case report and literature review. Am J Med 92: 681-685, 1992 (see comments).
5. Uchigata Y, Kuwata S, Tsushima T, et al. Patients with Graves' disease who developed insulin autoimmune syndrome (Hirata Disease) Possess HLA-Bw62/Cw4/DR4 carrying DRB1*0406. J Clin Endocrinol Metab 77: 249-254, 1993.
6. Antoniades HN, Huber AM, Boshell BR, Saravis CA, Gershof SN. Studies on the state of insulin in blood: properties of circulating "free" and "bound" insulin. Endocrinology 76: 709-721, 1965.
7. Ichihara K, Shima K, Saito Y, Nonaka K, Tarui S. Mechanism of hypoglycemia observed in a patient with insulin autoimmune syndrome. Diabetes 26: 500-506, 1977.
8. Okabe N, Inoue K, Mori R. Effects of antithyroid drugs on lymphocyte prosiferative responses to lectins: relationship between insulin autoimmune syndrome and methimazole. J Clin Lab Immunol 11: 167-171, 1983.
9. Mori H, Nagai H, Koda A. Effect of alpha-mercaptopropionylglycine (alpha-MPG) and sodium dipropylacetate (DPA) on antibody formation (III) (author's transl). Nippon Yakurigaku Zasshi 74: 797-804, 1978.
10. Bodolay E, Suranyi P, Juhasz F, Stenszky V, Balazs C, Farid NR. Methimazole blocks Graves' IgG but not interferon-gamma HLA-DR expression by thyroid cells. Immunol Lett 18: 167-171, 1988.
11. Corrales JJ, Orfao A, Lopez A, Mories MT, Miralles JM, Ciudad J. Analysis of IL-2 and IL-6 Binding to Peripheral Blood Lymphocytes in Graves' Disease: Relationship with Disease Activity. Cytometry 30: 118-123, 1997.
12. Singer DS, Kohn LD, Zinger H, Mozes E. Methimazole prevents induction of experimental systemic lupus erythematosus in mice. J Immunol 153: 873-880, 1994.
13. Mozes E, Zinger H, Kohn LD, Singer DS. Spontaneous autoimmune disease in (NZBN̄VNZW)F1 mice is ameliorated by treatment with methimazole. J Clin Immunol 18: 106-113, 1998.
14. Chan CC, Gery I, Kohn LD, Nussenblatt RB, Mozes E, Singer DS. Periocular inflammation in mice with experimental systemic lupus erythematosus. A new experimental blepharitis and its modulation. J Immnol 154: 4830-4835, 1995.