Different effects of calcium antagonists, nitrates, and β-blockers on platelet function: Possible importance for the treatment of unstable angina

Circulation

Volumn 95, Issue 1, 1997, Pages 125-132

  Knight, Charles J ^a   Panesar, Manvinder ^b   Wilson, Darren J ^b   Chronos, Nicolas A F ^a   Patel, Deven ^a   Fox, Kim ^a   Goodall, Alison H ^b  

^a ROYAL BROMPTON HOSPITAL   (United Kingdom)

^b ROYAL FREE HOSPITAL   (United Kingdom)

Author keywords

angina; drugs; platelets

Indexed keywords

ADRENALIN; AMLODIPINE; ATENOLOL; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM ANTAGONIST; FIBRINOGEN; GLYCERYL TRINITRATE; NITRATE; PADGEM PROTEIN;

ADULT; ARTICLE; CALCIUM CELL LEVEL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEGRANULATION; DOSE RESPONSE; DRUG POTENTIATION; HUMAN; HUMAN EXPERIMENT; INTRAVENOUS DRUG ADMINISTRATION; MALE; NORMAL HUMAN; PRIORITY JOURNAL; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; THROMBOCYTE FUNCTION; UNSTABLE ANGINA PECTORIS;

EID: 0031014496     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.95.1.125     Document Type: Article

References (10)

1. Fuster V, Badimon L, Badimon JJ, Chesebro JH. The pathogenesis of coronary artery disease and the acute coronary syndromes (pt 2). N Engl J Med. 1992;326:310-318.
2. Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990's. Nature. 1993;362:801-809.
3. Lewis HD, Davis JW, Archibald DG, Steinke WE, Smitherman TC, Doherty JE, Schnaper HW, LeWinter MM, Linares E, Pouget JM, Sabhanval SC, Chesler E, DeMots H. Protective effects of aspirin against acute myocardial infarction and death in men with unstable angina: results of a Veterans Administration Cooperative Study. N Engl J Med. 1983;309:396-403.
4. Holland Interuniversity Nifedipine/Metoprolol Trial (HINT) Research Group. Early treatment of unstable angina in the coronary care unit: a randomised, double-blind placebo-controlled comparison of recurrent ischemia in patients treated with nifedipine, or metoprolol or both. Br Heart J. 1986;56:400-413.
5. Held PH, Yusuf S, Furberg CD. Calcium channel blockers in acute myocardial infarction and unstable angina: an overview. Br Med J. 1989;299:1187-1192.
6. Mellion BT, Ignarro LJ, Ohlstein EH, Pontecorvo EG, Hyman AL, Kadowitz PJ. Evidence for the inhibitory role of guanosine 3′, 5′-monophosphate in ADP-induced human platelet aggregation in the presence of nitric oxide and related vasodilators. Blood. 1981;57: 946-955.
7. Schafer AI, Alexander RW, Handlin RI. Inhibition of platelet function by organic nitrate vasodilators. Blood. 1980;55:649-654.
8. Fitzgerald DJ, Roy L, Robertson RM, Fitzgerald GA. The effects of organic nitrates on prostacyclin biosynthesis and platelet function in humans. Circulation. 1984;70:297-302.
9. Mehta J, Mehta P. Comparative effects of nitroprusside and nitroglycerin on platelet aggregation in patients with heart failure. J Cardiovasc Pharmacol. 1980;2:25-33.
10. Wallen NH, Andersson A, Hjemdahl P. Effects of treatment with oral isosorbide dinitrate on platelet function in vivo: a double-blind placebo-controlled study in patients with stable angina pectoris. Br J Clin Pharmacol. 1994;38:63-70.