Depletion of systemic macrophages by liposome-encapsulated clodronate attenuates increases in brain quinolinic acid during CNS-localized and systemic immune activation

Journal of Neurochemistry

Volumn 73, Issue 2, 1999, Pages 770-779

  Koennecke, Lutz A ^a   Zito, Mark A ^a   Proescholdt, Margit G ^a   Van Rooijen, Nico ^b   Heyes, Melvyn P ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^b VU UNIVERSITY AMSTERDAM   (Netherlands)

Author keywords

Endotoxin; Inflammation; Liposome encapsulated clodronate; Macrophage; Quinolinic acid

Indexed keywords

CLODRONIC ACID; LIPOSOME; QUINOLINIC ACID;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG BRAIN LEVEL; DRUG DELIVERY SYSTEM; GERBIL; IMMUNOSTIMULATION; MACROPHAGE ACTIVATION; MACROPHAGE FUNCTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; TISSUE DISTRIBUTION;

ANIMALS; BRAIN CHEMISTRY; CEREBELLUM; CLODRONIC ACID; CORPUS STRIATUM; DRUG COMPOUNDING; ENCEPHALITIS; FEMALE; GERBILLINAE; LECTINS; LIPOPOLYSACCHARIDES; LIPOSOMES; MACROPHAGES; MICROGLIA; NEUROIMMUNOMODULATION; PLANT LECTINS; QUINOLINIC ACID;

ANIMALIA; GERBILLINAE;

EID: 0032778869     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1999.0730770.x     Document Type: Article

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