Directly-coupled HPLC-NMR spectroscopic studies of metabolism and futile deacetylation of phenacetin in the rat

Journal of Pharmaceutical and Biomedical Analysis

Volumn 20, Issue 6, 1999, Pages 865-873

  Nicholls, Andrew W ^a   Lindon, John C ^a   Farrant, R Duncan ^b   Shockcor, John P ^c   Wilson, Ian D ^d   Nicholson, Jeremy K ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

^c DUPONT COMPANY   (United States)

^d A   (United Kingdom)

Author keywords

4 Acetamidophenol; 2H labelling; Futile deacetylation; HPLC NMR; Metabolites; Paracetamol; Phenacetin; Rat

Indexed keywords

PHENACETIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEACETYLATION; DRUG METABOLISM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; RAT; SOLID PHASE EXTRACTION; TECHNIQUE; URINALYSIS;

EID: 0032778392     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0731-7085(99)00104-1     Document Type: Article

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