Analysis of brain proteins in Alzheimer's disease using high-resolution two-dimensional gel electrophoresis

Journal of the Neurological Sciences

Volumn 166, Issue 2, 1999, Pages 100-106

  Tsuji, T ^a   Shimohama, S ^a   Kamiya, S ^a   Sazuka, T ^b   Ohara, O ^b  

^a KYOTO UNIVERSITY   (Japan)

^b KAZUSA DNA RESEARCH INSTITUTE   (Japan)

Author keywords

Alzheimer's disease; Database; Internet; Protein; Two dimensional gel electrophoresis

Indexed keywords

AMYLOID PRECURSOR PROTEIN; BRAIN PROTEIN; GLIAL FIBRILLARY ACIDIC PROTEIN; HEAT SHOCK PROTEIN;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; AUTOPSY; CLINICAL ARTICLE; CONTROLLED STUDY; DATA ANALYSIS; DATA BASE; HUMAN; HUMAN TISSUE; INTERNET; PRIORITY JOURNAL; PROTEIN ANALYSIS; TWO DIMENSIONAL GEL ELECTROPHORESIS;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; HUMANS; MIDDLE AGED; PROTEINS; REPRODUCIBILITY OF RESULTS; TEMPORAL LOBE;

EID: 0032776935     PISSN: 0022510X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-510X(99)00120-3     Document Type: Article

References (31)

1. Joachim C.L., Selkoe D.J. The seminal role of beta-amyloid in the pathogenesis of Alzheimer disease. Alzheimer Dis Assoc Disord. 6:1992;7-34.
2. Joachim C.L., Morris J.H., Selkoe D.J. Diffuse senile plaques occur commonly in the cerebellum in Alzheimer's disease. Am J Pathol. 135:1989;309-319.
3. Seubert P., Oltersdorf T., Lee M.G., Barbour R., Blomquist C., Davis D.L., Bryant K., Fritz L.C., Galasko D., Thal L.J., Lieberburg I., Schenk D.B. Secretion of beta-amyloid precursor protein cleaved at the amino terminus of the beta-amyloid peptide. Nature. 361:1993;260-263.
4. Shoji M., Golde T.E., Ghiso J., Cheung T.T., Estus S., Shaffer L.M., Cai X.D., McKay D.M., Tintner R., Frangione B., Yonkin S.G. Production of the Alzheimer amyloid beta protein by normal proteolytic processing. Science. 258:1992;126-129.
5. Yen S.H., Dickson D.W., Crowe A., Butler M., Shelanski M.L. Alzheimer's neurofibrillary tangles contain unique epitopes and epitopes in common with the heat-stable microtubule associated proteins tau and MAP2. Am J Pathol. 126:1987;81-91.
6. Cribbs D.H., Chen L.S., Bende S.M., LaFerla F.M. Widespread neuronal expression of the presenilin-1 early-onset Alzheimer's disease gene in the murine brain. Am J Pathol. 148:1996;1797-1806.
7. Duff K., Eckman C., Zehr C., Yu X., Prada C.M., Pereztur J., Hutton M., Buee L., Harigaya Y., Yager D., Morgan D., Gordon M.N., Holcomb L., Refolo L., Zenk B., Hardy J., Younkin S. Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1. Nature. 383:1996;710-713.
8. Taylor J.E., Tinklenberg J.R., Eng L.F., Yesavage J.A., Vinogradov S., Davies H.G., Gonzalez De Whitt P.A., Frossard P.M. Association study between Alzheimer's disease and restriction fragment length polymorphisms at the human amyloid beta protein gene locus. Mol Biol Med. 5:1988;167-172.
9. Tanaka H., Naruse S., Seki K., Onodera O., Kobayashi H., Miyatake T., Shibata A., Sakaki Y., Kamino K., Miki T., Nukina N., Imagawa M., Nakano I., Shimizu T., Kojima T., Hardy J., Tsuji S. Absence of linkage disequilibrium at amyloid precursor protein gene locus in Japanese familial Alzheimer's disease with 717Val→Ile mutation. Neurosci Lett. 162:1993;63-66.
10. Mullan M. Familial Alzheimer's disease: second gene locus located (Editorial). Br Med J. 305:1992;1108-1109.
11. The genome directory. Nature 1995;377:1-379.
12. O'Farrell P. High resolution two-dimensional elecrophoresis of proteins. J Biol Chem. 250:1975;4007-4021.
13. Bjellqvist B., Ek K., Gighetti P.G., Gianazza E., Gorg A., Westerneier R., Postel W. Isoelectric focusing in immobilized pH gradients: principle, methodology and some applications. J Biochem Biophys Methods. 6:1982;317-339.
14. Görg A., Postel W., Günther S. The current state of two-dimensional electrophoresis with immobilized pH gradients. Electrophoresis. 9:1988;531-546.
15. Cade Treyer D., Cade A., Darjo A., Jouvion Moreno M. Isoelectric focusing and titration curves in biomedicine and in agrofood industries: a multimedia teaching program. Electrophoresis. 17:1996;479-482.
16. Corbett J.M., Dunn M.J., Posch A., Gorg A. Positional reproducibility of protein spots in two-dimensional polyacrylamide gel electrophoresis using immobilised pH gradient isoelectric focusing in the first dimension: an interlaboratory comparison. Electrophoresis. 15:1994;1205-1211.
17. Michea Hamzehpour M., Sanchez J.C., Epp S.F., Paquet N., Hughes G.J., Hochstrasser D., Pechere J.C. Two-dimensional polyacrylamide gel electrophoresis isolation and microsequencing of Pseudomonas aeruginosa proteins. Enzyme Protein. 47:1993;1-8.
18. 2+ agonists on molecular chaperones in human umbilical vein endothelial cells. Electrophoresis. 16:1995;1205-1214.
19. Mirra S.S., Heyman A., McKeel D., Sumi S.M., Crain B.J., Brownlee L.M., Vogel F.S., Hughes J.P., van Belle G., Berg L. The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease. Neurology. 41:1991;479-486.
20. Gorg A., Postel W., Domscheit A., Gunther S. Two-dimensional electrophoresis with immobilized pH gradients of leaf proteins from barley (Hordeum vulgare): method, reproducibility and genetic aspects. Electrophoresis. 9:1988;681-692.
21. Cleveland D.W., Fischer S.G., Kirschner M.W., Laemmli U.K. Peptide mapping by limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis. J Biol Chem. 252:1977;1102-1106.
22. Conner E.A., Wirth P.J. Protein alterations associated with gene amplification in cultured human and rodent cells. Electrophoresis. 17:1996;1257-1264.
23. Gorg A., Postel W., Gunther S., Weser J., Strahler J.R., Hanash S.M., Somerlot L., Kuick R. Approach to stationary two-dimensional pattern: influence of focusing time and immobiline/carrier ampholytes concentrations. Electrophoresis. 9:1988;37-46.
24. Sinha P.K., Praus M., Kottgen E., Gianazza E., Righetti P.G. Two-dimensional maps in the most extended (pH 2.5-11) immobilized pH gradient interval. J Biochem Biophys Methods. 21:1990;173-179.
25. Appel R.D., Hochstrasser D.F., Funk M., Vargas J.R., Pellegrini C., Muller A.F., Scherrer J.R. The MELANIE project: from a biopsy to automatic protein map interpretation by computer. Electrophoresis. 12:1991;722-735.
26. Hochstrasser D.F., Appel R.D., Vargas R., Perrier R., Vurlod J.F., Ravier F., Pasquali C., Funk M., Pellegrini C., Muller A.F., Scherrer J.R. A clinical molecular scanner: the Melanie project. MD Comput. 8:1991;85-91.
27. Janke C., Holzer M., Klose J., Arendt T. Distribution of isoforms of the microtubule-associated protein tau in grey and white matter areas of human brain: a two-dimensional gel electrophoretic analysis. FEBS Lett. 379:1996;222-226.
28. Autilio Gambetti L., Morandi A., Tabaton M., Schaetzle B., Kovacs D., Perry G., Sharma S., Cornette J., Greenberg B., Gambetti P. The amyloid precursor protein of Alzheimer disease is expressed as a 130 kDa polypeptide in various cultured cell types. FEBS Lett. 241:1988;94-98.
29. Jabbour W., Pouplard Barthelaix A., Houlgatte R., Emile J. Abnormal expression of actin in lymphocytes of Alzheimer's disease and Down's syndrome patients. J Neuroimmunol. 38:1992;199-208.
30. Perez N., Sugar J., Charya S., Johnson G., Merril C., Bierer L., Perl D., Haroutunian V., Wallace W. Increased synthesis and accumulation of heat shock 70 proteins in Alzheimer's disease. Mol Brain Res. 11:1991;249-254.
31. Mattila K.M., Frey H. Alzheimer brain proteins investigated by two-dimensional gel electrophoresis with immobilized pH gradients in the first dimension. Electrophoresis. 15:1994;721-725.