Cellular immune responses in mice infected with the intestinal nematode Trichuris muris

Experimental Parasitology

Volumn 92, Issue 1, 1999, Pages 40-47

  Soltys, Jindrich ^a   Goyal, Prem K ^b   Wakelin, Derek ^c  

^a PARASITOLOGICAL INSTITUTE   (Slovakia)

^b VIKRAM UNIVERSITY   (India)

^c UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

Anergy; CD28; IFN IL 5; T helper cells; Trichuris muris

Indexed keywords

CD28 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; CELL SURFACE MARKER; CYTOKINE; GAMMA INTERFERON;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELLULAR IMMUNITY; CLONAL ANERGY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DOWN REGULATION; FEMALE; HELPER CELL; INTERFERON PRODUCTION; LYMPHOCYTE PROLIFERATION; MOUSE; NEMATODIASIS; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE SUBPOPULATION; TRICHURIS;

ANIMALIA; NEMATODA; TRICHURIS MURIS;

EID: 0032776634     PISSN: 00144894     EISSN: None     Source Type: Journal    
DOI: 10.1006/expr.1999.4397     Document Type: Article

References (22)

1. Abrams J. S. Immunoenzymetric assay of mouse and human cytokines using NIP-labelled anti-cytokine antibodies. Current Protocols in Immunology. 1995;Wiley, New York. p. 6.20.1-6.20.11.
2. Allen J. E., Lawrence R. A., Maizels R. M. APC from mice harboring the filarial nematode,Brugia malayi. International Immunology. 8:1996;143-151.
3. Allen J. E., MacDonald A. S. Profound suppression of cellular proliferation mediated by the secretions of nematodes. Parasite Immunology. 20:1998;241-247.
4. Bellaby T., Robinson K. J., Wakelin D. Induction of differential T helper responses in mice infected with the parasitic nematodeTrichuris muris. Infection and Immunity. 24:1996;3113-3118.
5. Else K. J., Wakelin D. The effects of resistance of H-2 and -H-2 genes on the expulsion of the nematodeTrichuris muris. Parasitology. 96:1988;543-550.
6. Else K. J., Wakelin D. Genetically determined influences on the ability of poor responder mice to respond to immunisation againstTrichuris muris. Parasitology. 100:1990;479-489.
7. Else K. J., Grencis R. K. Helper T-cell subsets in mouse trichuriasis. Parasitology Today. 7:1991;313-316.
8. Else K. J., Hultner G. M., Grencis R. K. Cellular immune responses to the murine nematode parasiteTrichuris muris. Immunology. 75:1992a;232-237.
9. Else, K. J. Hultner, L. Grencis, R. K. 1992b, Modulation of cytokine production and response phenotypes in murine trichuriasis, Parasite Immunology, 14, 441, 449.
10. Greenwald R. J., Lu P., Halvorson M. J., Zhou X. D., Chen S J., Madden K. B., Perrin P. J., Morris S. J., Finkelman F. D., Peach R., Linsley P. S., Urban J. F., Gause W. C. Effects of blocking B7-1 and B7-2 interactions during a type 2in vivo. Journal of Immunology. 158:1997;4088-4096.
11. Grencis, R. K. 1996, T cell and cytokine basis of host variability in response to intestinal nematode infections, Parasitology, 112, 31, 37.
12. Hermanek J., Goyal P. K., Wakelin D. Lymphocyte, antibody and cytokine responses during concurrent infections between helminths that selectively promote T-helper-1 or T-helper-2 activity. Parasite Immunology. 16:1994;111.
13. Kearney E. R., Walunas T. L., Karr R. W., Morton P. A., Loh D. Y., Bluestone J. A., Jenkins M. K. Antigen dependent clonal expansion of a trace population of antigen-specific CD4+ T cellsin vivo. Journal of Immunology. 155:1995;1032-1036.
14. Koyama K., Tamauchi H., Ito Y. The role of CD4+ and CD8+ T cells in protective immunity to the murine nematode parasiteTrichuris muris. Parasite Immunology. 17:1995;161-165.
15. Kuchroo V. K., Das M. P., Brown J. A., Ranger A. M., Zamvil S. S., Sobel R. A., Weiner H. L., Nabavi N., Glimcher L. H. B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy. Cell. 80:1995;707-718.
16. Mahanty S., Nutman T. B. Immunoregulation in human lymphatic filariasis: The role of interleukin 10. Parasite Immunology. 17:1995;385-392.
17. Muller D. L., Jenkins M. K. Molecular mechanisms underlying functional T-cell unresponsiveness. Current Opinion in Immunology. 7:1995;375-381.
18. Ottis G., Yokoyama W. M., Holmes K. L. Flow Cytometry. Coligan J., Kruisbeek A., Margulies D., Shevach E., Strober W. Current Protocols in Immunology. 5.4:1995;1-5.4.9 Wiley, New York.
19. Sethma P. M., Van Parijs L., Sharpe A. H., Abbas A. K., Freeman G. J. A negative regulatory function of B7 revealed in B7-1 transgenic mice. Immunity. 1:1994;415-421.
20. +. Journal of Immunology. 147:1991;2713-2716.
21. Sher A., Gazinelli R. T., Oswald I. P., Clerici M., Kullberg M., Pearce E. J., Berzofsky J. A., Mosmann T. R., James S. L., Morshe H. C., Shearer G. M. Role of T cell derived cytokines in the downregulation of immune responses in parasitic and retroviral infection. Immunological Reviews. 217:1992;183-204.
22. Wakelin D, Selby G. R. The induction of immunological tolerance to the parasitic nematodeTrichuris muris. Immunology. 26:1974;1-10.