Oxymetazoline: Potential mechanisms of inhibitory effects on aqueous humor dynamics

Pharmacology

Volumn 53, Issue 4, 1996, Pages 259-270

  Chu, Teh Ching ^a   Ogidigben, Miller J ^a   Potter, David E ^a  

^a MOREHOUSE SCHOOL OF MEDICINE   (United States)

Author keywords

Aqueous humor flow; cAMP; Intraocular pressure; Oxymetazoline; Rabbit eyes; Receptors; 2

Indexed keywords

2 (1 METHYL 2 ISOINDOLINYLMETHYL) 2 IMIDAZOLINE; ALPHA 2 ADRENERGIC RECEPTOR BLOCKING AGENT; ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; ALPHA 2A ADRENERGIC RECEPTOR; CYCLIC AMP; DICLOFENAC; EFAROXAN; IMIDAZOLINE; ISOPRENALINE; OXYMETAZOLINE; PROSTAGLANDIN SYNTHASE INHIBITOR; RAUWOLSCINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AQUEOUS HUMOR FLOW; ARTICLE; CILIARY BODY EPITHELIUM; CONTROLLED STUDY; DRUG MECHANISM; FEMALE; INTRAOCULAR HYPOTENSION; INTRAOCULAR PRESSURE; IRIS; MALE; MYDRIASIS; NONHUMAN; PRIORITY JOURNAL; RABBIT; TOPICAL DRUG ADMINISTRATION;

EID: 0029822963     PISSN: 00317012     EISSN: 14230313     Source Type: Journal    
DOI: 10.1159/000139438     Document Type: Article

References (28)

1. Makabe R: Ophthalmologische Un-tersuchungen mil Dichlorophenyl-aminoimidazolin, Dtsch Med Wo-chcnschr 1966;91:1686-1696.
2. Hodapp E, Kolker AE, Kass MA, Goldberg I, Becker B, Gordon M: The elTcct of topical clonidine on intraocular pressure, Arch Ophthalmol 1981;99:1208-1212.
3. Burke JA, Potter DE: Ocular effects of a relatively selective 12 agonist (UK-14,304-18) in cats, rabbits and monkeys, CurrEye Res 1986,5:665-676.
4. Potter DE, Ogidigben MJ: Medc-tomidine-induccd alterations of intraocular pressure and contraction of the nictitating membrane, Invest Ophthalmol Vis Sci 1991:32:2799-2805.
5. Bausher LP, Gregory DS, Sears ML: Interaction between alpha-2 and beta-2 adrenergic receptors in rabbit ciliary process, Curr Eye Res 1987; 6:497-505.
6. Liu JHK, Neufeld AH: Study of central regulation of intraocular pressure using vcntriculocisternal perfusion, Invest Ophthalmol Vis Sci 1985;26:136-143.
7. Campbell WR, Potter DE: Centrally mediated ocular hypotension: potential role of imidazoline receptors, Ann NY Acad Sci 1995:763:463-485.
8. Bylund DB: Subtypes of d1-and ar adrenergic receptors, FASEB J 1992;6:832-839.
9. Bylund DB, Ray-Prenger C, Murphy TJ: Alpha-2A and alpha-2B adrenergic receptor subtypes: Antagonists binding in tissues and cell lines containing only one subtype, J Pharmacol ExpTher 1988:245:600-607.
10. Emsberger PR, Westbrooks KL, Christen MO, Schafer SG: A second generation of centrally acting antihypertensive agents act on putative Ii-imidazoline receptors, J Cardio-vasc Pharmacol 1992;20(suppl 4): 1-10.
11. Duzman E, Anderson J, Vita JB, Lue JC, Chen C-C, Leopold IH: Topically applied oxymetazolinc, Arch Ophthalmol 1983:101:1122-1126.
12. Murray DL, Leopold IH: Alpha-adrenergic receptors in rabbit eyes, J Ocul Pharmacol 1985:1:3-18.
13. Wilson C, Becker B: Oxymetazolinc HC1: Effects of topical application on intraocular pressure (IOP) and pupil diameter in New Zealand white rabbits, Invest Ophthalmol Vis Sci 1991;33(ARVOsuppl): 1248.
14. Wang RF, Lee PY, Taniguchi T, Becker B, Podos SM, Serie JB, Mittag TW: Effect of oxymetazolinc on aqueous humor dynamics and ocular blood flow in monkeys and rabbits, Arch Ophthalmol 1993;111: 535-538.
15. Rowland JM, Potter DE, Reiter RJ: Circadian rhythm in an intraocular pressure model, Curr Eye Res 1981: 1:169-173.
16. Ogidigben MJ, Chu TC, Potter DE: Ocular actions of moxonidine: A possible role for imidazoline receptors, J Pharmacol Exp The: 1994: 269:897-904.
17. Yablonski ME, Zimmerman TJ, Waltman SR, Becker B: A fluoro-pholometric study of the effect of topical timolol on aqueous humor dynamics, Exp Eye Res 1978,27: 135-142.
18. Brubaker RF: Measurement of aqueous flow by fluorophotometry: in Ritch R, Shields MB, Krupin T (eds): The Glaucomas, St, Louis, Mosby, 1989, pp 337-344.
19. Ogidigben MJ, Chu TC, Potter DE: Alpha-2 adrenoceptor mediated changes in aqueous dynamics: Effect of pertussis, Exp Eye Res 1994;58: 729-736.
20. Wang RF, Carnras CB, Podos SM, Lee KW, Bhuyan KC, Bhuyan DK: The role of prostaglandins in the para-atninoclonidine-induced reduction of intraocular pressure, Trans Am Ophthalmol Soc 1989:87: 94-106.
21. Murphy TJ, Bylund DB: Oxymeta-zoline inhibits adenylate cyclase by activation of serotonin-1 receptors in the OK cell, an established renal epithelial cell line, Mol Pharmacol 1988;34:1-7.
22. Wikberg JE, Uhlen S, Chhajlani V: Medetomidine stereoisomers delineate two closely related subtypes of idazoxan (imidazoline) 1 receptors in the guinea pig, Eur J Pharmacol 1991:193:335-340.
23. Bende M, Loth S: Vascular effects of topical oxymetazolinc on human nasal mucosa, J Laryngol Otol 1966; 100:285-288.
24. Duzman E, Warman A, Warman R: Efficacy and safety of topical oxy-metazoline in treating allergic and environmental conjunctivitis, Ann Ophthalmol 1986;13:28-31.
25. Covington T, Pau A: Oxymetazol-ine, Am Pharm 1985;5:21-26.
26. Yoshitomi T, Horio B, Gregory DS: Changes in aqueous norepinephrine and cyclic adenosine monophosphate during the circadian cycle in rabbits, Invest Ophthalmol Vis Sci 1991:32:1609-1613.
27. Sulewski ME, Robin AL, Cummings HL, Arkin LM: Effects of topical flurbiprofen on the intraocular pressure lowering effects of apraclonid-ine and timolol, Arch Ophthalmol 1991;109:807-809.
28. Jin Y, Vcrstappcr A, Yorio T: Characterization of zx;-adrenoceptor binding sites in rabbit ciliary body membranes, Invest Ophthalmol Vis Sci 1994:35:2500-2508.