MMH cells: An in vitro model for the study of retinol-binding protein secretion regulated by retinol

Journal of Cellular Physiology

Volumn 181, Issue 1, 1999, Pages 24-32

  Bellovino, D ^a   Lanyau, Y ^a,d   Garaguso, I ^a   Amicone, L ^b   Cavallari, C ^b   Tripodi, M ^c   Gaetani, S ^a  

^a ISTITUTO NAZIONALE DELLA NUTRIZIONE   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c UNIVERSITY OF CAGLIARI   (Italy)

^d INSTITUTO NACIONAL DE HIGIENE   (Cuba)

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; CERULOPLASMIN; RETINOL; RETINOL BINDING PROTEIN; SCATTER FACTOR RECEPTOR; TRANSFERRIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL LABELING; CELL TRANSFORMATION; DRUG ABSORPTION; FEMALE; HUMAN; HUMAN CELL; LIVER CELL; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECRETION; RETINOL DEFICIENCY; TRANSCRIPTION REGULATION;

ANIMALS; CELL LINE; HOMEOSTASIS; HUMANS; LIVER; MICE; MICE, TRANSGENIC; MODELS, BIOLOGICAL; RETINOL-BINDING PROTEINS; VITAMIN A; VITAMIN A DEFICIENCY;

EID: 0032773859     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4652(199910)181:1<24::AID-JCP3>3.0.CO;2-0     Document Type: Article

References (25)

1. Aiuti A, Cicchini C, Bernardini S, Fedele G, Amicone L, Fantoni A, Tripodi M. 1998. Hematopoietic support and cytokine expression of murine stable hepatocyte cell lines (MMH). Hepatology 28:1645-1654.
2. Amicone L, Galimi MA, Spagnoli FM, Tommasini C, De Luca V, Tripodi M. 1995. Temporal and tissue-specific expression of the MET ORF driven by the complete transcriptional unit of human A1AT gene in transgenic mice. Gene 162:323-328.
3. Amicone L, Spagnoli FM, Spath G, Giordano S, Tommasini C, Bernardini S, De Luca V, Della Rocca C, Weiss MC, Comoglio PM, Tripodi M. 1997. Transgenic expression in the liver of truncated Met blocks apoptosis and permits immortalization of hepatocytes. EMBO J 16:495-503.
4. Bellovino D, Morimoto T, Tosetti F, Gaetani S. 1996. Retinol-binding protein and transthyretin are secreted as a complex formed in the endoplasmic reticulum in HepG2 human hepatocarcinoma cells. Exp Cell Res 222:77-83.
5. Bellovino D, Morimoto T, Pisaniello A, Gaetani S. 1998. In vitro and in vivo studies on transthyretin oligomerization. Exp Cell Res 243: 101-112.
6. Blomhoff R. 1994. Overview of vitamin A: metabolism and function. In: Blomhoff R, editor. Vitamin A in health and disease. New York: Marcel Dekker. p 1-35.
7. Chamberlain JP. 1979. Fluorographic detection of radioactivity in polyacrylamide gels with water soluble fluor, sodium salicylate. Anal Biochem 268:5182-5192.
8. Chirgwin JM, Przybyla AE, Mac Donald RJ, Rutter WI. 1979. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry 18:5294-5299.
9. Colantuoni V, Romano V, Bensi G, Santoro C, Costanzo F, Raugei G, Izzo P, Pietropaolo TC, Bougueleret L, Cimino F, Salvatore F, Cortese R. 1983. Cloning and sequencing of a full-length cDNA coding for human retinol-binding protein. Nucleic Acids Res 11: 7769-7776.
10. Dixon JL, Goodman DS. 1987a. Effects of nutritional and hormonal factors on the metabolism of retinol-binding protein by primary cultures of rat hepatocytes. J Cell Physiol 130:6-13.
11. Dixon JL, Goodman DS. 1987b. Studies on the metabolism of retinol-binding protein by primary hepatocytes from retinol-deficient rats. J Cell Physiol 130:14-20.
12. Mangelsdorf DJ, Umesono K, Evans RM. 1994. The retinoid receptors. In: Sporn MB, Roberts AB, Goodman DS, editors. The retinoids: biology, chemistry and medicine. 2nd ed. New York: Raven Press, p 319-349.
13. Marinari L, Lenich CM, Ross AC. 1987. Production and secretion of retinol-binding protein by a human hepatoma cell line, HepG2. J Lipid Res 28:941-948.
14. Mehlus H, Nilsson T, Peterson PA, Rask L. 1991. Retinol-binding protein and transthyretin expressed in Hela cells form a complex in the endoplasmic reticulum both in the absence and in the presence of retinol. Exp Cell Res 197:119-124.
15. Mehlus H, Brehon L, Rask L, Peterson PA. 1992. Ligand-dependent secretion of rat retinol-binding protein expressed in Hela cells. J Biol Chem 267:12036-12041.
16. Perozzi G, Mengheri E, Colantuoni V, Gaetani S. 1991. Vitamin A intake and in vivo expression of the genes involved in retinol transport. Eur J Biochem 196:211-217.
17. Perozzi G, Barilà D, Sambuy Y, Nobili F, Gaetani S. 1998. Effects of retinoids on gene expression in different epithelial models in vivo and in vitro. Zeit Ernahrungswiss 37(Suppl 1):29-34.
18. Reppe S, Smeland S, Moskaug JO, Blomhoff R. 1998. Retinol-induced secretion of human retinol-binding protein in yeast. FEBS Lett 427:213-219.
19. Ronne H, Ocklind C, Wiman K, Rask L, Obrink B, Peterson PA. 1983. Ligand-dependent regulation of intracellular protein transport: effect of vitamin A on the secretion of the retinol-binding protein. J Cell Biol 96:907-910.
20. Sambrook J, Fritsch EF, Maniatis T. 1989. Molecular cloning: a laboratory manual. 2nd ed. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press.
21. Smith JE, Borek C, Gawinowicz MA, Goodman DS. 1985. Structure-function relationship in their effects on retinol-binding protein metabolism in cultured H4IIEC3 liver cells. Arch Biochem Biophys 238:1-9.
22. Soprano DR, Blaner WS. 1994. Plasma retinol-binding protein. In: Sporn MB, Roberts AB, Goodman DS, editors. The retinoids: biology, chemistry and medicine. 2nd ed. New York: Raven Press. p 257-282.
23. Spagnoli FM, Amicone L, Tripodi M, Weiss MC. 1998. Identification of a bipotential precursor cell in hepatic cell line derived from transgenic mice expressing cyto-Met in the liver. J Cell Biol 143:1101-1112.
24. Tosetti F, Ferrari N, Pfeffer U, Brigati C, Vidali G. 1992. Regulation of plasma retinol binding protein secretion in human HepG2 cells. Exp Cell Res 200:467-472.
25. Tosetti F, Pedemonte V, Pfeffer U, Brigati C, Ferrari N, Vidali G. 1994. Cellular fate of plasma retinol binding protein. In: Livrea MA, Vidali G, editors. Retinoids: from basic science to clinical application. Basel: Birkhauser-Verlag. p 103-113.