메뉴 건너뛰기




Volumn 11, Issue 6, 1999, Pages 607-615

Evidence-based therapy of primary biliary cirrhosis

Author keywords

Drug therapy; Outcome measures; Primary biliary cirrhosis (PBC); Randomized controlled trials; Therapeutic trials

Indexed keywords

AZATHIOPRINE; BILE ACID; BISPHOSPHONIC ACID DERIVATIVE; CHLORAMBUCIL; COLCHICINE; CORTICOSTEROID; CYCLOSPORIN; IMMUNOSUPPRESSIVE AGENT; METHOTREXATE; PENICILLAMINE; PREDNISOLONE; URSODEOXYCHOLIC ACID;

EID: 0032772919     PISSN: 0954691X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00042737-199906000-00005     Document Type: Review
Times cited : (23)

References (57)
  • 1
    • 0028364179 scopus 로고
    • Primary biliary cirrhosis: Survival of a large cohort of symptomatic and asymptomatic patients followed for 24 years
    • 1• Mahl T, Shockcor W, Boyer JL. Primary biliary cirrhosis: survival of a large cohort of symptomatic and asymptomatic patients followed for 24 years. J Hepatol 1994; 20:707-713. The tremendous difference in survival between asymptomatic and symptomatic patients suggests that clinical trials should stratify for this factor.
    • (1994) J Hepatol , vol.20 , pp. 707-713
    • Mahl, T.1    Shockcor, W.2    Boyer, J.L.3
  • 2
    • 0030055090 scopus 로고    scopus 로고
    • Accuracy of staging in primary biliary cirrhosis
    • 2 Garrido MC, Hubscher SG. Accuracy of staging in primary biliary cirrhosis. J Clin Pathol 1996; 49:556-559.
    • (1996) J Clin Pathol , vol.49 , pp. 556-559
    • Garrido, M.C.1    Hubscher, S.G.2
  • 3
    • 4243388612 scopus 로고    scopus 로고
    • How many portal tracts are necessary to make a diagnosis of significant bile duct loss (SBDL)?
    • 3 Tadrous PJ, Goldin RD. How many portal tracts are necessary to make a diagnosis of significant bile duct loss (SBDL)? [Abstract]. J Pathol 1997; 181:11A.
    • (1997) J Pathol , vol.181
    • Tadrous, P.J.1    Goldin, R.D.2
  • 4
    • 0017227743 scopus 로고
    • A prospective controlled trial of azathioprine in primary biliary cirrhosis
    • 4 Heathcote J, Ross A, Sherlock S. A prospective controlled trial of azathioprine in primary biliary cirrhosis. Gastroenterology 1976; 70:656-659.
    • (1976) Gastroenterology , vol.70 , pp. 656-659
    • Heathcote, J.1    Ross, A.2    Sherlock, S.3
  • 5
    • 0022406713 scopus 로고
    • Beneficial effect of azathioprine and prediction of prognosis in primary biliary cirrhosis: Final results of an international trial
    • 5• Christensen E, Neuberger J, Crowe J, Altman DG, Popper H, Portmann B, et al. Beneficial effect of azathioprine and prediction of prognosis in primary biliary cirrhosis: final results of an international trial. Gastroenterology 1985; 89:1084-1091. Well-conducted study but rather high withdrawal rate; it is unfortunate that baseline conditions were not the same for the two randomized groups.
    • (1985) Gastroenterology , vol.89 , pp. 1084-1091
    • Christensen, E.1    Neuberger, J.2    Crowe, J.3    Altman, D.G.4    Popper, H.5    Portmann, B.6
  • 6
    • 0019181618 scopus 로고
    • Effects of cyclosporin A on suppressor and inducer T lymphocytes in primary biliary cirrhosis
    • 6 Routhier G, Janossy G, Epstein O, Thomas HC, Sherlock S. Effects of cyclosporin A on suppressor and inducer T lymphocytes in primary biliary cirrhosis. Lancet 1980; ii:1223-1226.
    • (1980) Lancet , vol.2 , pp. 1223-1226
    • Routhier, G.1    Janossy, G.2    Epstein, O.3    Thomas, H.C.4    Sherlock, S.5
  • 7
    • 0023692133 scopus 로고
    • Pilot study of cyclosporin A in patients with symptomatic primary biliary cirrhosis
    • 7 Minuk G, Bohme C, Burgess E, Hershfield N, Kelly J, Shaffer E, et al. Pilot study of cyclosporin A in patients with symptomatic primary biliary cirrhosis. Gastroenterology 1988; 95:1356-1363.
    • (1988) Gastroenterology , vol.95 , pp. 1356-1363
    • Minuk, G.1    Bohme, C.2    Burgess, E.3    Hershfield, N.4    Kelly, J.5    Shaffer, E.6
  • 9
    • 0018380993 scopus 로고
    • Serum bilirubin: A prognostic factor in primary biliary cirrhosis
    • 9•• Shapiro JM, Smith H, Schaffner F. Serum bilirubin: a prognostic factor in primary biliary cirrhosis. Gut 1979; 20:137-140. A classic article assessing the value of serum bilirubin as a surrogate marker of survival.
    • (1979) Gut , vol.20 , pp. 137-140
    • Shapiro, J.M.1    Smith, H.2    Schaffner, F.3
  • 11
    • 0020701724 scopus 로고
    • The prognostic importance of clinical and histological features in asymptomatic and symptomatic primary biliary cirrhosis
    • 11 Roll J, Boyer JL, Barry D, Klatskin G. The prognostic importance of clinical and histological features in asymptomatic and symptomatic primary biliary cirrhosis. N Engl J Med 1983; 308:1-7.
    • (1983) N Engl J Med , vol.308 , pp. 1-7
    • Roll, J.1    Boyer, J.L.2    Barry, D.3    Klatskin, G.4
  • 12
    • 0026517987 scopus 로고
    • Nodular regenerative hyperplasia of the liver in early histological stages of primary biliary cirrhosis
    • 12 Colina F, Pinedo F, Solis JA, Moreno D, Nevado M. Nodular regenerative hyperplasia of the liver in early histological stages of primary biliary cirrhosis. Gastroenterology 1992; 102:1319-1324.
    • (1992) Gastroenterology , vol.102 , pp. 1319-1324
    • Colina, F.1    Pinedo, F.2    Solis, J.A.3    Moreno, D.4    Nevado, M.5
  • 13
    • 0027396144 scopus 로고
    • Cyclosporin A treatment in primary biliary cirrhosis: Results of a long-term placebo controlled trial
    • 13•• Lombard M, Portmann B, Neuberger J. Cyclosporin A treatment in primary biliary cirrhosis: results of a long-term placebo controlled trial. Gastroenterology 1993; 104:519-526. Superbly designed and conducted study but dissimilarity in baseline characteristics between the two randomized groups necessitated complex statistical analyses which reduces the credibility of the results.
    • (1993) Gastroenterology , vol.104 , pp. 519-526
    • Lombard, M.1    Portmann, B.2    Neuberger, J.3
  • 14
    • 0013872374 scopus 로고
    • The late results of long-term treatment of primary biliary cirrhosis by corticosteroids
    • 14 Howat HT, Ralston AJ, Varley H, Wilson JA. The late results of long-term treatment of primary biliary cirrhosis by corticosteroids. Rev Int Hepatol 1966; 16:227-238.
    • (1966) Rev Int Hepatol , vol.16 , pp. 227-238
    • Howat, H.T.1    Ralston, A.J.2    Varley, H.3    Wilson, J.A.4
  • 16
    • 0031054020 scopus 로고    scopus 로고
    • Cyclical etidronate in the prevention of bone loss in corticosteroid-treated primary biliary cirrhosis. A prospective, controlled pilot study
    • 16• Wolfhagen FHJ, van Buren HR, denOuden JW, Hop WCJ, van Leeuwen JPTM, Schalm SW, et al. Cyclical etidronate in the prevention of bone loss in corticosteroid-treated primary biliary cirrhosis. A prospective, controlled pilot study. J Hepatol 1997; 26:325-330. Well-conducted study clearly shows the benefit of bisphosphonate therapy in reducing vertebral bone loss in PBC patients treated with steroids.
    • (1997) J Hepatol , vol.26 , pp. 325-330
    • Wolfhagen, F.H.J.1    Van Buren, H.R.2    DenOuden, J.W.3    Hop, W.C.J.4    Van Leeuwen, J.P.T.M.5    Schalm, S.W.6
  • 17
    • 0026014151 scopus 로고
    • Treatment of primary biliary cirrhosis with low-dose weekly methotrexate
    • 17 Kaplan MM, Knox TA. Treatment of primary biliary cirrhosis with low-dose weekly methotrexate. Gastroenterology 1991; 101:1332-1338.
    • (1991) Gastroenterology , vol.101 , pp. 1332-1338
    • Kaplan, M.M.1    Knox, T.A.2
  • 18
    • 0000695074 scopus 로고    scopus 로고
    • Low-dose methotrexate in primary biliary cirrhosis: Long-term results of a placebo-controlled trial
    • 18 Hendrickse M, Rigney E, Giaffer MH, Soomoro I, Triger DR, Underwood JC, et al. Low-dose methotrexate in primary biliary cirrhosis: long-term results of a placebo-controlled trial [Abstract]. Hepatology 1997; 26:248A.
    • (1997) Hepatology , vol.26
    • Hendrickse, M.1    Rigney, E.2    Giaffer, M.H.3    Soomoro, I.4    Triger, D.R.5    Underwood, J.C.6
  • 19
    • 0029122841 scopus 로고
    • The combination of ursodeoxycholic acid and methotrexate for patients with primary biliary cirrhosis: The results of a pilot study
    • 19 Lindor KD, Dickson ER, Jorgenson RA, Anderson ML, Wiesner RH, Gores GJ, et al. The combination of ursodeoxycholic acid and methotrexate for patients with primary biliary cirrhosis: the results of a pilot study. Hepatology 1995; 22:1158-1162.
    • (1995) Hepatology , vol.22 , pp. 1158-1162
    • Lindor, K.D.1    Dickson, E.R.2    Jorgenson, R.A.3    Anderson, M.L.4    Wiesner, R.H.5    Gores, G.J.6
  • 23
    • 0023875186 scopus 로고
    • Evaluation of colchicine therapy in primary biliary cirrhosis
    • 23 Bodenheimer H, Schaffner F, Pessullo J. Evaluation of colchicine therapy in primary biliary cirrhosis. Gastroenterology 1988; 95:124-129.
    • (1988) Gastroenterology , vol.95 , pp. 124-129
    • Bodenheimer, H.1    Schaffner, F.2    Pessullo, J.3
  • 24
    • 0021809682 scopus 로고
    • Gallstone dissolution with ursodeoxycholic acid in patients with chronic active hepatitis and two years follow-up. A pilot study
    • 24 Leuschner U, Leuschner M, Sieratzki J, Kurtz W, Hubner K. Gallstone dissolution with ursodeoxycholic acid in patients with chronic active hepatitis and two years follow-up. A pilot study. Dig Dis Sci 1985; 30:642-649.
    • (1985) Dig Dis Sci , vol.30 , pp. 642-649
    • Leuschner, U.1    Leuschner, M.2    Sieratzki, J.3    Kurtz, W.4    Hubner, K.5
  • 25
    • 0023125182 scopus 로고
    • Is ursodeoxycholic acid an effective treatment for primary biliary cirrhosis?
    • 25• Poupon R, Poupon RE, Calmus Y, Chretien Y, Ballet F, Darnis F. Is ursodeoxycholic acid an effective treatment for primary biliary cirrhosis? Lancet 1987; i:834-836. The pivotal pilot study of UDCA in PBC demonstrating a marked benefit of therapy on serum bilirubin.
    • (1987) Lancet , vol.1 , pp. 834-836
    • Poupon, R.1    Poupon, R.E.2    Calmus, Y.3    Chretien, Y.4    Ballet, F.5    Darnis, F.6
  • 26
    • 0024464260 scopus 로고
    • Ursodeoxycholic acid in primary biliary cirrhosis: Results of a controlled double-blind trial
    • 26 Leuschner U, Fischer H, Kurtz W, Guldutuna S, Hubner K, Hellstern A, et al. Ursodeoxycholic acid in primary biliary cirrhosis: results of a controlled double-blind trial. Gastroenterology 1989; 97:1268-1274.
    • (1989) Gastroenterology , vol.97 , pp. 1268-1274
    • Leuschner, U.1    Fischer, H.2    Kurtz, W.3    Guldutuna, S.4    Hubner, K.5    Hellstern, A.6
  • 27
    • 0000691741 scopus 로고
    • A randomized controlled trial of ursodeoxycholic acid (UDCA) in primary biliary cirrhosis (PBC)
    • 27 Hadziyannis SJ, Hadziyannis ES, Makris A. A randomized controlled trial of ursodeoxycholic acid (UDCA) in primary biliary cirrhosis (PBC) [Abstract]. Hepatology 1989; 10:580.
    • (1989) Hepatology , vol.10 , pp. 580
    • Hadziyannis, S.J.1    Hadziyannis, E.S.2    Makris, A.3
  • 28
    • 0025611350 scopus 로고
    • A multi-centre double-blind controlled trial of ursodeoxycholic acid for primary biliary cirrhosis
    • 28 Oka H, Toda G, Ikeda Y, Hashimoto N, Hasumura Y, Kamimura T, et al. A multi-centre double-blind controlled trial of ursodeoxycholic acid for primary biliary cirrhosis. Gastroenterol Jpn 1990; 25:774-780.
    • (1990) Gastroenterol Jpn , vol.25 , pp. 774-780
    • Oka, H.1    Toda, G.2    Ikeda, Y.3    Hashimoto, N.4    Hasumura, Y.5    Kamimura, T.6
  • 29
    • 0025876404 scopus 로고
    • A multicentre controlled trial of ursodiol for the treatment of primary biliary cirrhosis
    • 29•• Poupon RE, Balkau B, Eschwege E, Poupon R, the UDCA-PBC Study Group. A multicentre controlled trial of ursodiol for the treatment of primary biliary cirrhosis. N Engl J Med 1991; 324:1548-1554. Landmark paper on the value of UDCA in the management of PBC.
    • (1991) N Engl J Med , vol.324 , pp. 1548-1554
    • Poupon, R.E.1    Balkau, B.2    Eschwege, E.3    Poupon, R.4
  • 30
    • 0027286162 scopus 로고
    • Ursodeoxycholic acid in the long term treatment of primary biliary cirrhosis: A short term, randomized, double-blind controlled, cross-over study with long term follow-up
    • 30 Hwang SJ, Chan C, Lee S-D, Wu JC, Tsay SH, Lo KJ. Ursodeoxycholic acid in the long term treatment of primary biliary cirrhosis: a short term, randomized, double-blind controlled, cross-over study with long term follow-up. J Gastroenterol Hepatol 1993; 8:217-223.
    • (1993) J Gastroenterol Hepatol , vol.8 , pp. 217-223
    • Hwang, S.J.1    Chan, C.2    Lee, S.-D.3    Wu, J.C.4    Tsay, S.H.5    Lo, K.J.6
  • 31
    • 0027309033 scopus 로고
    • Ursodeoxycholic acid for symptomatic primary biliary cirrhosis. Preliminary analysis of a double-blind multicentre trial
    • 31 Battezzati PM, Podda M, Bianchi FB, Naccarato R, Orlandi F, Surrenti C, et al. Ursodeoxycholic acid for symptomatic primary biliary cirrhosis. Preliminary analysis of a double-blind multicentre trial. J Hepatology 1993; 17:332-338.
    • (1993) J Hepatology , vol.17 , pp. 332-338
    • Battezzati, P.M.1    Podda, M.2    Bianchi, F.B.3    Naccarato, R.4    Orlandi, F.5    Surrenti, C.6
  • 32
    • 0028331716 scopus 로고
    • Ursodeoxycholic acid in the treatment of primary biliary cirrhosis
    • 32• Lindor KD, Dickson ER, Baldus WP, Jorgensen RA, Ludwig J, Murtaugh PA, et al. Ursodeoxycholic acid in the treatment of primary biliary cirrhosis. Gastroenterology 1994; 106:1284-1290. A four-year study validating the earlier results reported by Poupon et al. [29]
    • (1994) Gastroenterology , vol.106 , pp. 1284-1290
    • Lindor, K.D.1    Dickson, E.R.2    Baldus, W.P.3    Jorgensen, R.A.4    Ludwig, J.5    Murtaugh, P.A.6
  • 33
    • 0028346255 scopus 로고
    • The canadian multicentre double-blind randomized controlled trial of ursodeoxycholic acid in primary biliary cirrhosis
    • 33• Heathcote EJ, Cauch-Dudek K, Walker V, Bailey RJ, Blendis LM, Ghent CN, et al. The Canadian multicentre double-blind randomized controlled trial of ursodeoxycholic acid in primary biliary cirrhosis. Hepatology 1994; 19:1149-1156. A well-conducted study with a simple primary outcome measure - bilirubin, which also confirmed the beneficial effect of UDCA in PBC.
    • (1994) Hepatology , vol.19 , pp. 1149-1156
    • Heathcote, E.J.1    Cauch-Dudek, K.2    Walker, V.3    Bailey, R.J.4    Blendis, L.M.5    Ghent, C.N.6
  • 35
    • 0029127685 scopus 로고
    • A randomized, double-blind, placebo-controlled trial of ursodeoxycholic acid in primary biliary cirrhosis
    • 35• Combes B, Carithers RL, Maddrey WC, Lin D, McDonald MF, Wheeler DE, et al. A randomized, double-blind, placebo-controlled trial of ursodeoxycholic acid in primary biliary cirrhosis. Hepatology 1995; 22:759-766. Another well-conducted study using a smaller dose of UDCA than the previous three large UDCA trials - with less clinical benefit.
    • (1995) Hepatology , vol.22 , pp. 759-766
    • Combes, B.1    Carithers, R.L.2    Maddrey, W.C.3    Lin, D.4    McDonald, M.F.5    Wheeler, D.E.6
  • 36
    • 8044244818 scopus 로고    scopus 로고
    • Ursodeoxycholic acid treatment in patients with primary biliary cirrhosis. A Swedish multi-centre, double-blind, randomized controlled study
    • 36 Eriksson LS, Olsson R, Glauman H, Prytz H, Befrits R, Ryden BO, et al. Ursodeoxycholic acid treatment in patients with primary biliary cirrhosis. A Swedish multi-centre, double-blind, randomized controlled study. Scand J Gastroenterol 1997; 32:179-186.
    • (1997) Scand J Gastroenterol , vol.32 , pp. 179-186
    • Eriksson, L.S.1    Olsson, R.2    Glauman, H.3    Prytz, H.4    Befrits, R.5    Ryden, B.O.6
  • 37
    • 0030926120 scopus 로고    scopus 로고
    • Cytotoxicity of bile salts against biliary epithelium: A study in isolated bile ductule fragments and isolated perfused rat liver
    • 37• Benedetti A, Alvaro D, Bassotti C, Gigliozzi A, Ferretti G, LaRosa T, et al. Cytotoxicity of bile salts against biliary epithelium: a study in isolated bile ductule fragments and isolated perfused rat liver. Hepatology 1997; 26:9-21. Excellent study of scanning electron microscopy showing the toxic effects of unconjugated bile acids on the biliary epithelial cells.
    • (1997) Hepatology , vol.26 , pp. 9-21
    • Benedetti, A.1    Alvaro, D.2    Bassotti, C.3    Gigliozzi, A.4    Ferretti, G.5    LaRosa, T.6
  • 38
    • 0028084463 scopus 로고
    • Kinetics of hepatic bile acid handling in cholestatic liver disease: Effect of ursodeoxycholic acid
    • 38•• Jazrawi RP, Caestecker JS, Goggin PM, Britten AJ, Joseph AEA, Maxwell JD, et al. Kinetics of hepatic bile acid handling in cholestatic liver disease: effect of ursodeoxycholic acid. Gastroenterology 1994; 106:134-143. Excellent study using an in vivo technique to measure bile acid transport in PBC and primary sclerosing cholangitis (PSC).
    • (1994) Gastroenterology , vol.106 , pp. 134-143
    • Jazrawi, R.P.1    Caestecker, J.S.2    Goggin, P.M.3    Britten, A.J.4    Joseph, A.E.A.5    Maxwell, J.D.6
  • 39
    • 0026584970 scopus 로고
    • Scintigraphic documentation of an improvement in hepatobiliary excretory function after treatment with ursodeoxycholic acid in patients with cystic fibrosis and associated liver disease
    • 39 Colombo C, Castellani MR, Balistreri WF, Seregni E, Assaisso ML, Giunta A. Scintigraphic documentation of an improvement in hepatobiliary excretory function after treatment with ursodeoxycholic acid in patients with cystic fibrosis and associated liver disease. Hepatology 1992; 15:677-684.
    • (1992) Hepatology , vol.15 , pp. 677-684
    • Colombo, C.1    Castellani, M.R.2    Balistreri, W.F.3    Seregni, E.4    Assaisso, M.L.5    Giunta, A.6
  • 40
    • 0031024075 scopus 로고    scopus 로고
    • Bile acid concentrations in human and rat liver tissue and in hepatocyte nuclei
    • 40•• Setchell KDR, Rodrigues CMP, Clerici C, Solinas A, Morelli A, Gartung C, et al. Bile acid concentrations in human and rat liver tissue and in hepatocyte nuclei. Gastroenterology 1997; 112:226-235. A landmark paper on the effect of UDCA in man, which actually measured the cytoplasmic and nuclear concentrations of endogenous bile salts in hepatocytes.
    • (1997) Gastroenterology , vol.112 , pp. 226-235
    • Setchell, K.D.R.1    Rodrigues, C.M.P.2    Clerici, C.3    Solinas, A.4    Morelli, A.5    Gartung, C.6
  • 41
    • 0025017364 scopus 로고
    • Acute effects of ursodeoxycholic and chenodeoxycholic acid on the small intestinal absorption of bile acids
    • 41• Stiehl A, Raedsch R, Rudolph G. Acute effects of ursodeoxycholic and chenodeoxycholic acid on the small intestinal absorption of bile acids. Gastroenterology 1990; 98:424-428.
    • (1990) Gastroenterology , vol.98 , pp. 424-428
    • Stiehl, A.1    Raedsch, R.2    Rudolph, G.3
  • 42
    • 0025047432 scopus 로고
    • Ursodeoxycholic acid-induced changes of plasma and urinary bile acids in patients with primary biliary cirrhosis
    • 42 Stiehl A, Rudolph G, Raedsch R, Moller B, Hopf U, Lotterer E, et al. Ursodeoxycholic acid-induced changes of plasma and urinary bile acids in patients with primary biliary cirrhosis. Hepatology 1990; 12:492-497.
    • (1990) Hepatology , vol.12 , pp. 492-497
    • Stiehl, A.1    Rudolph, G.2    Raedsch, R.3    Moller, B.4    Hopf, U.5    Lotterer, E.6
  • 43
    • 4244113849 scopus 로고    scopus 로고
    • Ursodeoxycholic acid feeding inhibits secretin-induced cholangiocyte secretory processes in bile duct ligated rats
    • 43 Alpini G, Glaser S, Caligiuri A, Phinizy J, Rodgers R, Francis H, et al. Ursodeoxycholic acid feeding inhibits secretin-induced cholangiocyte secretory processes in bile duct ligated rats [Abstract]. Gastroenterology 1998; 114:A1202.
    • (1998) Gastroenterology , vol.114
    • Alpini, G.1    Glaser, S.2    Caligiuri, A.3    Phinizy, J.4    Rodgers, R.5    Francis, H.6
  • 44
    • 0026657890 scopus 로고
    • Differential effects of chenodeoxycholic and ursodeoxycholic acids on interleukin 1, interleukin 6 and tumor necrosis factor-α production by monocytes
    • 44 Calmus Y, Guechot J, Podevin P, Bonnetis MT, Giboudeau J, Poupon R. Differential effects of chenodeoxycholic and ursodeoxycholic acids on interleukin 1, interleukin 6 and tumor necrosis factor-α production by monocytes. Hepatology 1992; 16:719-723.
    • (1992) Hepatology , vol.16 , pp. 719-723
    • Calmus, Y.1    Guechot, J.2    Podevin, P.3    Bonnetis, M.T.4    Giboudeau, J.5    Poupon, R.6
  • 46
    • 0025098908 scopus 로고
    • Hepatic expression of class I and class II major histocompatibility complex molecules in primary biliary cirrhosis: Effect of ursodeoxycholic acid
    • 46 Calmus Y, Gane P, Rouger P, Poupon R. Hepatic expression of class I and class II major histocompatibility complex molecules in primary biliary cirrhosis: effect of ursodeoxycholic acid. Hepatology 1990; 11:12-15.
    • (1990) Hepatology , vol.11 , pp. 12-15
    • Calmus, Y.1    Gane, P.2    Rouger, P.3    Poupon, R.4
  • 47
    • 0029825946 scopus 로고    scopus 로고
    • Effect of deoxycholic acid and ursodeoxycholic acid on lipid peroxidation in cultured macrophages
    • 47 Ljubuncic P, Fuhrman B, Oiknine J, Aviram M, Bomzon A. Effect of deoxycholic acid and ursodeoxycholic acid on lipid peroxidation in cultured macrophages. Gut 1996; 39:475-478.
    • (1996) Gut , vol.39 , pp. 475-478
    • Ljubuncic, P.1    Fuhrman, B.2    Oiknine, J.3    Aviram, M.4    Bomzon, A.5
  • 48
    • 0028294206 scopus 로고
    • Ursodiol for the long-term treatment of primary biliary cirrhosis
    • 48• Poupon RE, Poupon R, Balkau B, the UDCA-PBC Study Group. Ursodiol for the long-term treatment of primary biliary cirrhosis. N Engl J Med 1994; 330:1342-1347. The first time UDCA is shown to improve survival in patients with PBC - this effect was not seen after only two years of therapy [29].
    • (1994) N Engl J Med , vol.330 , pp. 1342-1347
    • Poupon, R.E.1    Poupon, R.2    Balkau, B.3
  • 49
    • 0030852495 scopus 로고    scopus 로고
    • Combined analysis of randomized controlled trials of ursodeoxycholic acid in primary biliary cirrhosis
    • 49•• Poupon RE, Lindor KD, Cauch-Dudek K, Dickson ER, Poupon R, Heathcote EJ. Combined analysis of randomized controlled trials of ursodeoxycholic acid in primary biliary cirrhosis. Gastroenterology 1997; 113:884-890. This study combined the raw data from the three largest UDCA trials and this had sufficient power to determine a survival benefit to UDCA-treated patients using the intention-to-treat principle and despite many patients going on open-label UDCA after two years on placebo.
    • (1997) Gastroenterology , vol.113 , pp. 884-890
    • Poupon, R.E.1    Lindor, K.D.2    Cauch-Dudek, K.3    Dickson, E.R.4    Poupon, R.5    Heathcote, E.J.6
  • 50
    • 0026690466 scopus 로고
    • Combination therapy with ursodeoxycholic acid and colchicine for primary biliary cirrhosis
    • 50 Shibata J, Fujiyama S, Honda Y, Sato T. Combination therapy with ursodeoxycholic acid and colchicine for primary biliary cirrhosis. J Gastroenterol Hepatol 1992; 7:277-282.
    • (1992) J Gastroenterol Hepatol , vol.7 , pp. 277-282
    • Shibata, J.1    Fujiyama, S.2    Honda, Y.3    Sato, T.4
  • 51
    • 0030046999 scopus 로고    scopus 로고
    • Effects of additional administration of colchicine in ursodeoxycholic acid-treated patients with primary biliary cirrhosis: A prospective randomized study
    • 51 Ikeda T, Tozuka S, Noguchi O, Kobayashi F, Sakamoto S, Marumo F, et al. Effects of additional administration of colchicine in ursodeoxycholic acid-treated patients with primary biliary cirrhosis: a prospective randomized study. J Hepatol 1996; 24:88-94.
    • (1996) J Hepatol , vol.24 , pp. 88-94
    • Ikeda, T.1    Tozuka, S.2    Noguchi, O.3    Kobayashi, F.4    Sakamoto, S.5    Marumo, F.6
  • 52
    • 10344254306 scopus 로고    scopus 로고
    • A randomized trial comparing colchicine and ursodeoxycholic acid combination to ursodeoxycholic acid in primary biliary cirrhosis
    • 52 Poupon RE, Huet PM, Poupon R, Bonnand A-M, Van Nhieu JT, Zafrani ES, et al. A randomized trial comparing colchicine and ursodeoxycholic acid combination to ursodeoxycholic acid in primary biliary cirrhosis. Hepatology 1996; 4:1098-1103.
    • (1996) Hepatology , vol.4 , pp. 1098-1103
    • Poupon, R.E.1    Huet, P.M.2    Poupon, R.3    Bonnand, A.-M.4    Van Nhieu, J.T.5    Zafrani, E.S.6
  • 53
    • 0030198972 scopus 로고    scopus 로고
    • Ursodeoxycholic acid and prenisolone versus ursodeoxycholic acid and placebo in the treatment of early stages of primary biliary cirrhosis
    • 53 Leuschner M, Guldutuna S, You T, Hubner K, Bhatti S, Leuschner L. Ursodeoxycholic acid and prenisolone versus ursodeoxycholic acid and placebo in the treatment of early stages of primary biliary cirrhosis. J Hepatol 1996; 25:49-57.
    • (1996) J Hepatol , vol.25 , pp. 49-57
    • Leuschner, M.1    Guldutuna, S.2    You, T.3    Hubner, K.4    Bhatti, S.5    Leuschner, L.6
  • 54
    • 0028355501 scopus 로고
    • Combined treatment with ursodeoxycholic acid and prednisone in primary biliary cirrhosis
    • 54 Wolfhagen FH, van Buren HR, Schalm SW. Combined treatment with ursodeoxycholic acid and prednisone in primary biliary cirrhosis. Neth J Med 1994; 44:84-90.
    • (1994) Neth J Med , vol.44 , pp. 84-90
    • Wolfhagen, F.H.1    Van Buren, H.R.2    Schalm, S.W.3
  • 55
    • 0029122841 scopus 로고
    • The combination of ursodeoxycholic acid and methotrexate for patients with primary biliary cirrhosis: The results of a pilot study
    • 55• Lindor KD, Dickson ER, Jorgenson RA, Anderson ML, Wiesner RH, Gores GJ, et al. The combination of ursodeoxycholic acid and methotrexate for patients with primary biliary cirrhosis: the results of a pilot study. Hepatology 1995; 22:1158-1162. A greater than 10% withdrawal rate due to methotrexate (moderate dose) toxicity is of great concern.
    • (1995) Hepatology , vol.22 , pp. 1158-1162
    • Lindor, K.D.1    Dickson, E.R.2    Jorgenson, R.A.3    Anderson, M.L.4    Wiesner, R.H.5    Gores, G.J.6
  • 56
    • 0343416897 scopus 로고    scopus 로고
    • The combination of ursodeoxycholic acid and methotrexate for primary biliary cirrhosis is not better than ursodeoxycholic acid alone
    • 56 Gonzalez-Koch A, Brahm J, Antezana C, Smok G, Cumsille MA. The combination of ursodeoxycholic acid and methotrexate for primary biliary cirrhosis is not better than ursodeoxycholic acid alone. J Hepatol 1997; 27:143-149.
    • (1997) J Hepatol , vol.27 , pp. 143-149
    • Gonzalez-Koch, A.1    Brahm, J.2    Antezana, C.3    Smok, G.4    Cumsille, M.A.5
  • 57
    • 0027190525 scopus 로고
    • Positive responses to methotrexate and ursodeoxycholic acid in patients with primary biliary cirrhosis responding insufficiently to ursodeoxycholic acid alone
    • 57 Buscher HP, Zietzschmann Y, Gerok W. Positive responses to methotrexate and ursodeoxycholic acid in patients with primary biliary cirrhosis responding insufficiently to ursodeoxycholic acid alone. J Hepatol 1993; 18:9-14.
    • (1993) J Hepatol , vol.18 , pp. 9-14
    • Buscher, H.P.1    Zietzschmann, Y.2    Gerok, W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.