Complex formation between the anionic polymer (PAA) and a cationic drug (procaine HCl): Characterization by microcalorimetric studies

Pharmaceutical Research

Volumn 16, Issue 7, 1999, Pages 1125-1131

  Govender, Thirumala ^a   Ehtezazi, Touraj ^a   Stolnik, Snjezana ^a   Illum, Lisbeth ^a   Davis, Stanley S ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

Drug polymer interactions; Electrostatic and non electrostatic interactions; Isothermal titration microcalorimetry; Salt dependence

Indexed keywords

POLYACRYLIC ACID; PROCAINE;

ARTICLE; DRUG DELIVERY SYSTEM; DRUG RELEASE; ELECTRICITY; ENTROPY; MICROCALORIMETRY; PRIORITY JOURNAL; STOICHIOMETRY; THERMODYNAMICS;

ACRYLIC RESINS; ANESTHETICS, LOCAL; ANIONS; BINDING SITES; CALORIMETRY; CATIONS; CHEMISTRY, PHYSICAL; ELECTROSTATICS; KINETICS; POTASSIUM CHLORIDE; PROCAINE; THERMODYNAMICS;

EID: 0032772646     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1018912522342     Document Type: Article

References (30)

1. M. R. Jenquin and J. W. McGinity. Characterisation of acrylic resin matrix films and mechanisms of drug-polymer interactions. Int. J. Pharm. 101:23-34 (1994).
2. A. Harada and K. Kataoka. Novel polyion complex micelles entrapping enzyme molecules in the core: Preparation of narrowly distributed micelles from lysozyme and poly (ethylene glycol)- poly(aspartic acid) block copolymer in aqueous medium. Macromolecules 31:288-294 (1998).
3. E. Allémann, R. Gurny, and E. Doelker. Drug loaded nanoparticles: Preparation methods and drug targeting issues. Eur. J. Pharm. Biopharm. 39:173-191 (1993).
4. S. S Davis. Biomedical applications of nanotechnology-implications for drug targeting and gene therapy. Trends Biotechnol. 15:217-224 (1997).
5. T. Govender, S. Stolnik, M. C. Garnett, L. Illum, and S. S. Davis. PLGA nanoparticles prepared by nanoprecipitation: Drug loading and release studies of a water soluble drug. J. Contr. Rel. 57:171-185 (1999).
6. P. R. Dash, V. Toncheva, E. Schacht, and L. W. Seymour. Synthetic polymers for vectorial delivery of DNA: characterisation of polymer-DNA complexes by photon correlation spectroscopy and stability to nuclease degradation and disruption by polyanions in vitro. J. Contr. Rel. 48:269-276 (1997).
7. T. Wiseman, S. Williston, J. F. Brandts, and L. N. Lin. Rapid measurement of binding constants and heats of binding using a new titration calorimeter. Anal. Biochem. 179:131-137 (1989).
8. M. L. Doyle. Characterisation of binding interactions by isothermal titration calorimetry. Curr. Opin. Biotechnol. 8:31-35 (1997).
9. M. F. Lu, S. Borodkin, L. Woodward, P. Li, C. Diesner, L. Hernandez, and M. Vadnere. A polymer carrier system for taste masking of macrolide antibiotics. Pharm. Res, 8:706-712 (1991).
10. B. O. Haglund, R. Joshi, and K. J. Himmelstein. An in situ gelling system for parenteral delivery. J. Contr. Rel. 41:229-235 (1996).
11. J. R. Robinson and W. J. Bologna. Vaginal and reproductive system treatments using a bioadhesive polymer. J. Contr. Rel. 28:87-94 (1994).
12. T. Lundback and T. Hard. Salt dependence of free energy, enthalpy, and entropy of nonsequcncc specific DNA binding. J. Phys. Chem. 100:17690-17695 (1996).
13. G. S. Manning. The molecular theory of polyelectrolyte solutions with applications to the electrostatic properties of polynucleotides. Quart. Rev. Biophys. 2:179-246 (1978).
14. G. S. Manning. Limiting laws and counterion condensation in polyelectrolyte solutions. I. Colligative properties. J. Phys. Chem. 51:924-933 (1969).
15. G. S. Manning. On the application of polyelectrolyte limiting laws to the helix-coil transition of DNA. I. Excess univalent cations. BIPMA. 11:937-949 (1972).
16. M. T. Jr. Record, C. F. Anderson, and T. M. Lohman. Thermodynamic analysis of ion effects on the binding and conformational equilibria of proteins and nucleic acids: the roles of ion association or release, screening, and ion effects on water activity. Quart. Rev. Biophys. 2:103-178 (1978).
17. M. T. Jr. Record, M. T. Lohman, and P. de Haseth. Ion effects on ligand-nucleic acid interactions. J. Mol. Bio. 107:145-158 (1976).
18. 2+ with DNA: A calorimetric and equilibrium binding study. J. Am. Chem. Soc. 117:4788-4796 (1995).
19. T. Lundback, H. Hansson, S. Knapp, R. Ladenstein, and T. Hard. Thermodynamic characterization of non-sequence-specific DNA- binding by the sso7d protein from sulfolobus solfataricus. J. Mol. Biol. 276:775-786 (1998).
20. T. M. Lohman, P. L. de Haseth, and M. T. Jr. Record. Pentalysine- deoxyribonucleic acid interactions: A model for the general effects of ion concentrations on the interactions of proteins with nucleic acids. Biochemistry 19:3522-3530 (1980).
21. T. M. Lohman and D. P. Mascotti. Thermodynamics of ligandnucleic acid interactions. Methods Enzymol. 221:400-424 (1992).
22. 65 binding mode. Cation and anion effects and polynucleotide specificity. Biochemistry 27:456-471 (1988).
23. L. B. Overman and T. M. Lohman. Linkage of pH, anion and cation effects in protein-nucleic acid equilibria. J. Mol. Biol. 236:165-178. (1994).
24. D. P. Mascotti and T. M. Lohman. Thermodynamics of single- strand RNA binding to oligosines containing tryptophan. Biochemistry 31:8932-8946 (1992).
25. H. Aki and M. Yamamoto. Biothermodynamic characterization of monocarboxylic and dicarboxylic aliphatic acids binding to human serum albumin: A flow microcalorimetric study. Biophys. Chem. 46:91-99 (1993).
26. H. Aki, M. Goto, and M. Yamamoto. Thermodynamic aspects of the molecular recognition of drugs by human serum albumin. Thermochimica Acta 251:379-388 (1995).
27. J. D. McGhee and P. J. Hippel. Theoretical aspects of DNA- protein interactions: Co-operative and non-co-operative binding of large ligands to a one-dimensional homogeneous lattice. J. Mol. Biol. 86:469-489 (1974).
28. A. C. Moffat, J. V. Jackson, M. S. Moss, and B. Widdop Clarke's isolation and identification of drugs, The Pharmaceutical Press, London, 1986.
29. C. B. Black and J, A. Cowan. Quantitative evaluation of electrostatic and hydrogen-binding contributions to metal cofactor binding to nucleic acids. J. Am. Chem. Soc. 116:1174-1178 (1994).
30. J. J. Kiefer, P. Somasundaran, and K. P. Ananthapadmanabhan. Interaction of tetradecyltrimethylammonium bromide with poly (acrylic acid) and poly (methacrylic acid). Effect of charge density. Langmuir 9:1187-1192 (1993).