Growth hormone replacement therapy in adults with growth hormone deficiency improves vascular reactivity

Clinical Endocrinology

Volumn 51, Issue 1, 1999, Pages 21-25

  Christ, Emanuel R ^a,b   Chowienczyk, Philip J ^a   Sönksen, Peter H ^a   Russel Jones, David L ^a  

^a ST THOMAS HOSPITAL   (United Kingdom)

^b GENEVA UNIVERSITY HOSPITALS   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH HORMONE; NITRIC OXIDE; NITROPRUSSIDE SODIUM;

ACETYLCHOLINE RELEASE; ADULT; AGED; ARTICLE; ATHEROSCLEROSIS; BLOOD FLOWMETRY; BLOOD SAMPLING; BLOOD VESSEL REACTIVITY; CARDIOVASCULAR RESPONSE; CLINICAL ARTICLE; DRUG EFFECT; FEMALE; FOREARM BLOOD FLOW; GROWTH HORMONE DEFICIENCY; HORMONE SUBSTITUTION; HUMAN; MALE; PRIORITY JOURNAL; SUBSTITUTION THERAPY; VASCULAR ENDOTHELIUM; VASODILATATION;

ACETYLCHOLINE; ADULT; AGED; CHOLESTEROL; ENDOTHELIUM, VASCULAR; FEMALE; FOREARM; GROWTH HORMONE; HEMOGLOBIN A, GLYCOSYLATED; HORMONE REPLACEMENT THERAPY; HUMANS; HYPOPITUITARISM; MALE; MIDDLE AGED; NITRIC OXIDE DONORS; NITROPRUSSIDE; REGIONAL BLOOD FLOW; TRIGLYCERIDES; VASODILATOR AGENTS;

EID: 0032770390     PISSN: 03000664     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2265.1999.00805.x     Document Type: Article

References (27)

1. Balaram, S.K., Agrawal, D.K., Allen, A.T., Kuszynski, C.A. & Edwards, J.D. (1997) Cell adhesion molecules and insulin-like growth factor-1 in vascular disease. Journal of Vascular Surgery, 25, 866-876.
2. Bar, R.S., Boes, M., Dake, B.L., Booth, B.A., Henley, S.A. & Sandra, A. (1988) Insulin, insulin-like growth factors, and vascular endothelium. American Journal of Medicine, 5a, 59-70.
3. Böger, R.H., Skamira, C., Bode-Böger, S.M., Brabant, G. & von zur Mühlen, A. (1996) Nitric oxide may mediate the hemodynamic effects of recombinant growth hormone in patients with auuired growth hormone deficiency. Journal of Clinical Investigation, 98, 2706-2713.
4. Bülow, B., Hagmar, L., Mikozy, Z., Nordstroem, C.H. & Erfurth, E.M. (1997) Increased cerebrovascular mortality in patients with hypopituitarism. Clinical Endocrinology, 46, 75-81.
5. Carroll, P.V., Christ, E.R. & Members of Growth Hormone Research Society Scientific Committee (1998) Growth hormone deficiency in adulthood and the effects of growth hormone replacement: a review. Journal of Clinical Endocrinology and Metabolism, 83, 382-395.
6. Chowienczyk, P.J., Kneale, B.J., Brett, S.E., Paganga, G., Jenkins, B.S. & Ritter, J.M. (1998) Lack of effect of vitamin E on L-arginine-responsive endothelial dysfunction in patients with mild hypercholesterolaemia and coronary artery disease. Clinical Science, 94, 129-134.
7. Cooke, J.P. & Tsao, P.S. (1994) Is NO an endogenous antiatherogenic molecule? Arteriosclerosis, 14, 653-655.
8. Daughaday, W.H. & Rotwein, P. (1989) Insulin-like growth factors I and II. Peptide, messenger ribonucleic acid and gene structures, serum, and tissue concentrations. Endocrine Reviews, 10, 68-91.
9. Fowelin, J., Attvall, S., Lager, I. & Bengtsson, B.-Å. (1993) Effects of treatment with recombinant human growth hormone on insulin sensitivity and glucose metabolism in adults with growth hormone deficiency. Metabolism: Clinical and Experimental, 42, 1443-1447.
10. Hasdai, D., Rizza, R.A., Holmes, D.R. Jr, Richardson, D.M., Cohen, P. & Lerman, A. (1998a) Insulin and insulin-like growth factor-1 cause coronary vasorelaxation in vitro. Hypertension, 32, 228-234.
11. Hasdai, D., Holmes, D.R. Jr, Richardson, D.M., Izhar, U. & Lerman, A. (1998b) Insulin and IGF-I attenuate the coronary vasoconstrictor effects of endothelin-1 but not of sarafotoxin 6c. Cardiovascular Research, 39, 644-650.
12. Haylor, J., Singh, I. & El Nahas, A.M. (1991) Nitric oxide inhibitor prevents vasodilation by insulin-like growth factor 1. Kidney International, 39, 333-335.
13. Hokanson, D.E., Sumner, D.S. & Strandness, D.E. Jr (1975) An electrically calibrated plethysmograph for direct measurement of limb blood flow. IEEE. Trans Biomedical Engineering, 22, 25-29.
14. Johansson, J.O., Landin, K., Tengborn, L., Rosen, T. & Bengtsson, B.-Å. (1994) High fibrinogen and plasminogen activator inhibitor activity in growth hormone-deficient adults. Arteriosclerosis, Thrombosis, and Vascular Biology, 4, 434-437.
15. Lehmann, E.D., Hopkins, K.D., Weissberger, A.J., Gosling, R.G. & Sönksen, P.H. (1993) Aortic distensibility in growth hormone deficient adults. Lancet, 341, 309.
16. Markussis, V., Beshyah, S.A., Fisher, C., Sharp, P., Nicolaides, A.N. & Johnston, D.G. (1992) Detection of premature atherosclerosis by high-resolution ultrasonography in symptom-free hypopituitary adults. Lancet, 340, 1188-1192.
17. Petrie, J.R., Ueda, S., Webb, D.J., Elliot, H.L. & Connell, J.M.C. (1996) Endothelial nitric oxide production and insulin sensitivity: a physiological link wilh implications for pathogenesis of cardiovascular disease. Circulation, 93, 1331-1333.
18. Pfeifer, M., Verhovec, R., Zizek, B., Prezelj, J., Poredos, P. & Clayton R.N. (1999) Growth hormone (GH) treatment reverses early atheroschlerotic changes in GH-deficient adults. Journal of Clinical Endocrinology and Metabolism, 84, 453-457.
19. Rosen, T. & Bengtsson, B.-Å. (1990) Premature mortality due to cardiovascular diseuse in hypopituitarism. Lancet, 336, 285-288.
20. Ross, R. (1993) The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature, 362, 801-809.
21. Seherrer, U., Randin, D., Vollenweider, P., Vollenweider, L. & Nicod, P. (1994) Nitric oxide release accounts for insulin's vascular effects in humans. Journal of Clinical Investigation, 94, 2511-2515.
22. Sönksen, P.H. (1976) Double antibody technique for the simultaneous assay of insulin and growth hormone. Hormones in Human Blood: Detection Assay. (ed. H. Antoniades), pp. 176-199. Harvard University Press, Cambridge/MA.
23. Teale, J.D. & Marks, V. (1990) Inappropriately elevated plasma insulin-like growth factor II in relation to suppressed insulin-like growth factor I in the diagnosis of non-islet cell tumor hypoglycaemia. Clinical Endocrinology, 33, 97-98.
24. Tribble, D.L., Holl, L.G., Wood, P.D. & Krauss, R.M. (1992) Variations in oxidative susceptibility among six low density lipoprotein subfractions of differing density and particle size. Atherosclerosis, 93, 189-199.
25. Vallance, P., Collier, J. & Moncada, S. (1989) Effects of endothelium-derived nitric oxide on peripheral arteriolar tone in man. Lancet, 2, 997-1000.
26. Whithey, R.J. (1953) The measurement of, changes in human limbs. Journal of Physiology, 121, 1-27.
27. Zeiher, A.M., Drexler, H., Wollschläger, H. & Just, H. (1991) Modulation of coronary vasomotor tone in humans. Progressive endothelial dysfunction with different early stages of coronary atherosclerosis. Circulation, 83, 391-401.