Pindolol increases extracellular 5-HT while inhibiting serotonergic neuronal activity

European Journal of Pharmacology

Volumn 377, Issue 2-3, 1999, Pages 187-191

  Fornal, Casimir A ^a   Martín, Francisco J ^a   Mendlin, Anna ^a   Metzler, Christine W ^a   Bjorvatn, Bjørn ^a   Jacobs, Barry L ^a  

^a Program in Neuroscience   (United States)

Author keywords

5 HT (5 hydroxytryptamine), extracellular; 5 HT(1A) autoreceptor; Microdialysis; Pindolol; Serotonergic neuronal activity; Serotonin; WAY 100635

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; AUTORECEPTOR; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; PINDOLOL; SEROTONIN; SEROTONIN 1A ANTAGONIST; SEROTONIN 1A RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; CAT; CAUDATE NUCLEUS; CONTROLLED STUDY; DORSAL RAPHE NUCLEUS; MALE; MICRODIALYSIS; NERVE CONDUCTION; NERVE ENDING; NONHUMAN; PRIORITY JOURNAL; SEROTONIN RELEASE; SEROTONINERGIC NERVE CELL; SUBCUTANEOUS DRUG ADMINISTRATION;

ANIMALS; BRAIN; CATS; CAUDATE NUCLEUS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; ELECTROPHYSIOLOGY; MALE; MICRODIALYSIS; NEURONS; PINDOLOL; PIPERAZINES; PYRIDINES; RAPHE NUCLEI; SEROTONIN; SEROTONIN ANTAGONISTS; TIME FACTORS;

EID: 0032769795     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(99)00430-6     Document Type: Article

References (22)

1. 1B receptors. Neuropharmacology. 35:1996;213-222.
2. 1A autoreceptors and increases dorsal raphe unit activity in awake cats. Eur. J. Pharmacol. 356:1998;167-178.
3. Blier P., Bergeron R. The use of pindolol to potentiate antidepressant medication. J. Clin. Psychiatry. 59(5):1998;16-23. Suppl.
4. Bosker F.J., Donker M.G., Klompmakers A.A., Kurata K., Westenberg H.G.M. 5-Hydroxytryptamine release in dorsal hippocampus of freely moving rats: modulation by pindolol. Prog. Neuropsychopharmacol. Biol. Psychiatry. 18:1994;765-778.
5. 1A autoreceptor in vivo. Br. J. Pharmacol. 124:1998;206-212.
6. 1A receptors. Neurochem. Res. 21:1996;557-562.
7. 1A antagonist, increases serotonergic neuronal activity in behaving cats: comparison with (S)-WAY-100135. J. Pharmacol. Exp. Ther. 278:1996;752-762.
8. 1A antagonist, does not reverse the inhibition of serotonergic neuronal activity induced by fluoxetine in awake cats: comparison with WAY-100635. J. Pharmacol. Exp. Ther. (in press).
9. Fornal, C.A., Martín, F.J., Metzler, C.W, Jacobs, B.L., 1999b. Pindolol suppresses serotonergic neuronal activity and does not block the inhibition of serotonergic neurons produced by 8-OH-DPAT in awake cats. J. Pharmacol. Exp. Ther. (in press).
10. Frazer A., Daws L.C. Serotonin transporter function in vivo: assessment by chronoamperometry. Ann. N.Y. Acad. Sci. 861:1998;217-229.
11. Fuller R.W. Uptake inhibitors increase extracellular serotonin concentration measured by brain microdialysis. Life Sci. 55:1994;163-167.
12. Gur E., Lerer B., Newman M.E. Chronic electroconvulsive shock and 5-HT autoreceptor activity in rat brain: an in vivo microdialysis study. J. Neural Transm. 104:1997;795-804.
13. Hjorth S. (-)-Pindolol, but not buspirone, potentiates the citalopram-induced rise in extracellular 5-hydroxytryptamine. Eur. J. Pharmacol. 303:1996;183-186.
14. 1A (auto)receptor-mediated decrease of 5-HT release in the rat brain in vivo. Fourth IUPHAR Satellite Meeting on Serotonin, Rotterdam, July 23-25.
15. Lejeune F., Gobert A., Rivet J.-M., Melon C., Cistarelli L., Millan M.J. (-)-Pindolol increases dialysate levels of dopamine (DA) and noradrenaline (NAD), but not serotonin (5-HT), in the frontal cortex (FCX) of freely moving rats. Soc. Neurosci. Abstr. 24:1998;861.
16. Maione S., Palazzo E., Pallotta M., Leyva J., Berrino L., Rossi F. Effects of imipramine on raphe nuclei and prefrontal cortex extracellular serotonin levels in the rat. Psychopharmacology. 134:1997;401-405.
17. Matos F.F., Urban C., Yocca F.D. Serotonin (5-HT) release in the dorsal raphe and ventral hippocampus: raphe control of somatodendritic and terminal 5-HT release. J. Neural Transm. 103:1996;103-190.
18. 2 receptors in apomorphine-induced facilitation of forebrain serotonin output. Eur. J. Pharmacol. 351:1998;291-298.
19. Middlemiss D.N. Blockade of the central 5-HT autoreceptor by β-adrenoceptor antagonists. Eur. J. Pharmacol. 120:1986;51-56.
20. Nathan I., Dvilansky A., Sage J., Korczyn A.D. Effects of propranolol and pindolol on platelet aggregation and serotonin release. Life Sci. 20:1977;407-411.
21. 1B/1D receptors on the modulation of acute fluoxetine-induced changes in 5-HT: the mechanism of action of (±)-pindolol. Soc. Neurosci. Abstr. 24:1998;1109.
22. 1A receptors: in vivo microdialysis and electrophysiological studies in the rat brain. Neuropsychopharmacology. 15:1996;349-360.